The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Antiviral Drugs in Wastewater and Surface Waters: A New Pharmaceutical Class of Environmental Relevance?
Abstract
An analytical method was developed for the determination of nine antiviral drugs (acyclovir, abacavir, lamivudine, nevirapine oseltamivir, penciclovir, ribavirin, stavudine, zidovudine) and one active metabolite (oseltamivir carboxylate) in raw and treated wastewater as well as in surface water using LC/ESI tandem MS detection. Relative recoveries exceeded 80% and limits of quantification ranged between 0.2 and 10 ng L(-1). Matrix effects were compensated by the use of stable isotope labeled surrogate standards and optimized chromatographic separation on a Hydro-RP column. All antiviral drugs, except ribavirin, were detected in raw wastewater. A significant reduction in concentrations was observed for acyclovir, lamivudine, and abacavir in treated wastewater indicating a substantial removal, while nevirapine, zidovudine and oseltamivir were found in similar concentrations in raw and treated wastewater. Concentrations in river waters were in the lower ng L(-1)-range, with a maximum of 190 and 170 ng L(-1) for acyclovir and zidovudine, respectively in the Hessian Ried. Estimated total compound loads in the Ruhr river ranged between <0.1 and 16.5 g d(-1) while for the Rhine river values between 370 and 1800 g d(-1) were determined. The ratios of oseltamivir to oseltamivir carboxylate were approximately a factor of 10 higher for the Rhine than for the other rivers and streams indicating a significant contribution from other sources such as discharges from manufacturing facilities.
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Cites
Global Patterns of Influenza A Virus in Wild Birds
Olsen, B., Munster, V. J., Wallensten, A., Waldenström, J., Osterhaus, A. D. M. E., & Fouchier, R. A. M. (2006) · Science · doi:10.1126/science.1122438 · Cited by 1,972
Hydrophilic interaction chromatography
Hemström, P., & Irgum, K. (2006) · Journal of Separation Science · doi:10.1002/jssc.200600199 · Cited by 1,176
Molecular Properties of WHO Essential Drugs and Provisional Biopharmaceutical Classification
Kasim, N. A., Whitehouse, M., Ramachandran, C., Bermejo, M., Lennernäs, H., Hussain, A. S., Junginger, H. E., Stavchansky, S. A., Midha, K. K., Shah, V. P., et al. (2004) · Molecular Pharmaceutics · doi:10.1021/mp034006h · Cited by 847
Strategies in the design of antiviral drugs
De Clercq, E. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd703 · Cited by 652
Organophosphorus flame retardants and plasticisers in surface waters
Andresen, J. A., Grundmann, A., & Bester, K. (2004) · Science of The Total Environment · doi:10.1016/j.scitotenv.2004.04.021 · Cited by 484
Ranking and prioritization of environmental risks of pharmaceuticals in surface waters
Sanderson, H., Johnson, D. J., Reitsma, T., Brain, R. A., Wilson, C. J., & Solomon, K. R. (2004) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2003.12.006 · Cited by 437
Separation efficiencies in hydrophilic interaction chromatography
Ikegami, T., Tomomatsu, K., Takubo, H., Horie, K., & Tanaka, N. (2008) · Journal of Chromatography A · doi:10.1016/j.chroma.2008.01.075 · Cited by 419
Guo, K., & Li, L. (2009) · Analytical Chemistry · doi:10.1021/ac900166a · Cited by 396
Pharmaceuticals in the Environment
(2008) · Springer eBooks · doi:10.1007/978-3-540-74664-5 · Cited by 255
Kloepfer, A., Quintana, J. B., & Reemtsma, T. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.11.101 · Cited by 198
Jung, B. H., Rezk, N. L., Bridges, A. S., Corbett, A. H., & Kashuba, A. D. M. (2007) · Biomedical Chromatography · doi:10.1002/bmc.865 · Cited by 189
Absorption of chemicals through compromised skin
Kežić, S., & Nielsen, J. B. (2009) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-009-0405-x · Cited by 127
Veal, G. J., & Back, D. J. (1995) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(95)00047-x · Cited by 114
Potential Risks Associated with the Proposed Widespread Use of Tamiflu
Singer, A. C., Nunn, M. A., Gould, E. A., & Johnson, A. C. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.9574 · Cited by 110
Fick, J. B., Lindberg, R. H., Tysklind, M., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000986 · Cited by 103
Lien, G., Chen, C., & Wang, G. (2008) · Journal of Chromatography A · doi:10.1016/j.chroma.2008.12.023 · Cited by 95
Esparza, X., Moyano, E., & Galcerán, M. T. (2009) · Journal of Chromatography A · doi:10.1016/j.chroma.2009.03.037 · Cited by 67
Qin, F., Zhao, Y., Sawyer, M. B., & Li, X. (2008) · Analytica Chimica Acta · doi:10.1016/j.aca.2008.07.036 · Cited by 61
The environmental fate of the antiviral drug oseltamivir carboxylate in different waters
Bartels, P., & von Tümpling, W. (2008) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2008.06.032 · Cited by 58
Meeting Report: Risk Assessment of Tamiflu Use Under Pandemic Conditions
Singer, A. C., Howard, B. M., Johnson, A. C., Knowles, C. J., Jackman, S. A., Accinelli, C., Caracciolo, A. B., Bernard, I., Bird, S., Boucard, T. K., et al. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.11310 · Cited by 53
Three decades of antiviral drugs
Clercq, E. D. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2485 · Cited by 47
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Ortúzar, M., Esterhuizen, M., Olicón-Hernández, D. R., González-López, J., & Aranda, E. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.869332 · Cited by 425
Environmental Mass Spectrometry: Emerging Contaminants and Current Issues
Richardson, S. D. (2012) · Analytical Chemistry · doi:10.1021/ac202903d · Cited by 323
Phillips, P. J., Smith, S. G., Kolpin, D. W., Zaugg, S. D., Buxton, H. T., Furlong, E. T., Esposito, K., & Stinson, B. (2010) · Environmental Science & Technology · doi:10.1021/es100356f · Cited by 288
Occurrence of selected antibiotics and antiretroviral drugs in Nairobi River Basin, Kenya
Ngumba, E., Gachanja, A., & Tuhkanen, T. (2016) · Science of The Total Environment · doi:10.1016/j.scitotenv.2015.08.139 · Cited by 268
Khan, G. A., Berglund, B., Khan, K. M., Lindgren, P.-E., & Fick, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062712 · Cited by 255
Metadata
- Authors
- Prasse, C., Schlüsener, M. P., Schulz, R., & Ternes, T. A.
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-01-28
- Volume
- 44
- Issue
- 5
- Pages
- 1728-1735
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- OpenAlex
- W2087260381
- Cited by
- 317
- References
- 21
- FWCI
- 14.48
- Type
- journal article
- Language
- en
- Open access
- closed
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