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Mechanistic Studies of the Oxidation of Isoniazid by the Catalase Peroxidase from Mycobacterium tuberculosis
Open accessAbstract
The enzymic oxidn. of isoniazid by the catalase-peroxidase of Mycobacterium tuberculosi was studied. The reaction products suggest two reaction pathways involving both electrophilic and radical species. Labeling expts. are consistent with a reaction mechanism involving the formation of an acyldiimide intermediate followed by decompn. to the corresponding aldehyde and peracid. The results suggest that isoniazid is oxidized by the catalase-peroxidase to a reactive species that may act by inactivating an essential enzyme of M. tuberculosis. [on SciFinder (R)]
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Cited by
Bacterial Fatty Acid Biosynthesis: Targets for Antibacterial Drug Discovery
Campbell, J. W., & Cronan, J. E. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.305 · Cited by 479
Compensatory ahp C Gene Expression in Isoniazid-Resistant Mycobacterium tuberculosis
Sherman, D. R., Mdluli, K., Hickey, M. J., Arain, T. M., Morris, S. L., Barry, C. E., & Stover, C. K. (1996) · Science · doi:10.1126/science.272.5268.1641 · Cited by 436
Mechanisms of action of isoniazid
Timmins, G. S., & Deretic, V. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05467.x · Cited by 421
Inhibition of a Mycobacterium tuberculosis β-Ketoacyl ACP Synthase by Isoniazid
Mdluli, K., Slayden, R. A., Zhu, Y., Ramaswamy, S., Pan, X., Mead, D., Crane, D. D., Musser, J. M., & Barry, C. E. (1998) · Science · doi:10.1126/science.280.5369.1607 · Cited by 398
Mechanisms of Drug Resistance in Mycobacterium tuberculosis
Heym, B., Philipp, W., & Cole, S. T. (1996) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-642-80166-2_3 · Cited by 379
Metadata
- Authors
- Johnsson, K., & Schultz, P. G.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 1994-08
- Volume
- 116
- Issue
- 16
- Pages
- 7425-7426
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2093602098
- Cited by
- 278
- References
- 0
- FWCI
- 9.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Johnsson, K., & Schultz, P. G. (1994). Mechanistic Studies of the Oxidation of Isoniazid by the Catalase Peroxidase from Mycobacterium tuberculosis. Journal of the American Chemical Society. https://doi.org/10.1021/ja00095a063
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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