The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Model-Free Analysis of Protein Backbone Motion from Residual Dipolar Couplings
Abstract
On the basis of the measurement of NH residual dipolar couplings (RDCs) in 11 different alignment media, an RDC-based order parameter is derived for each residue in the protein ubiquitin. Dipolar couplings are motionally averaged in the picosecond to millisecond time range and, therefore, reflect motion slower than the inverse overall tumbling correlation time of the protein. It is found that there is considerable motion that is slower than the correlation time and could not be detected with previous NMR methodology. Amplitudes and anisotropies of the motion can be derived from the model-free analysis. The method can be applied provided that at least five sufficiently different alignment media can be found for the biomolecule under investigation.
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Cites
Lipari, G., & Szabo, A. (1982) · Journal of the American Chemical Society · doi:10.1021/ja00381a009 · Cited by 3,777
Cited by
Recognition Dynamics Up to Microseconds Revealed from an RDC-Derived Ubiquitin Ensemble in Solution
Lange, O. F., Lakomek, N.-A., Farès, C., Schröder, G. F., Walter, K. F. A., Becker, S., Meiler, J., Grubmüller, H., Griesinger, C., & de Groot, B. L. (2008) · Science · doi:10.1126/science.1157092 · Cited by 1,044
Self-citationResidual Dipolar Couplings in Structure Determination of Biomolecules
Prestegard, J. H., Bougault, C. M., & Kishore, A. I. (2004) · Chemical Reviews · doi:10.1021/cr030419i · Cited by 416
Ulmer, T. S., Ramirez, B. E., Delaglio, F., & Bax, A. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0350684 · Cited by 301
Prediction of order parameters based on protein NMR structure ensemble and machine learning
Wang, Q., Miao, Z., Xiao, X., Zhang, X., Yang, D., Jiang, B., & Liu, M. (2024) · Journal of Biomolecular NMR · doi:10.1007/s10858-024-00435-w · Cited by 9
“It should be noted that, the dynamic time scale of order parameters could be extended from ps-ns to ps-ms range by measuring NH residual dipolar couplings in multiple alignments (Peti et al. 2002).”
Metadata
- Authors
- Peti, W., Meiler, J., Brüschweiler, R., & Griesinger, C.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-04-27
- Volume
- 124
- Issue
- 20
- Pages
- 5822-5833
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1980139576
- Cited by
- 207
- References
- 1
- FWCI
- 10.08
- Type
- journal article
- Language
- en
- Open access
- closed
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