CORRECTION OF THE STRUCTURE OF A URINARY METABOLITE OF ALDOSTERONE1
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCORRECTION OF THE STRUCTURE OF A URINARY METABOLITE OF ALDOSTERONE1Stanley Ulick, Kathryn Kusch, and J. T. AugustCite this: J. Am. Chem. Soc. 1961, 83, 21, 4482–4483Publication Date (Print):November 1, 1961Publication History Published online1 May 2002Published inissue 1 November 1961https://pubs.acs.org/doi/10.1021/ja01482a054https://doi.org/10.1021/ja01482a054research-articleACS PublicationsRequest reuse permissionsArticle Views30Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
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18-hydroxycorticosterone is converted to 18OHTHA, requiring additional conversion of the 11β-hydroxy group to an 11-keto group by HSD11B2.
“18-hydroxycorticosterone is converted to the tetrahydro metabolite, 18-hydroxy-tetrahydro-11-dehydrocorticosterone (18OHTHA), but this requires the additional conversion of the 11β-hydroxy group to an 11-keto group, a reaction catalyzed by HSD11B2 [[216], [217], [218]].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [216]
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Schiffer, L., Barnard, L., Baranowski, E. S., Gilligan, L. C., Taylor, A. E., Arlt, W., Shackleton, C. H. L., & Storbeck, K.-H. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105439 · Cited by 450 · see citing works
Identification of two C18 oxygenated corticosteroids isolated from human urine
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DETERMINATION OF PLASMA-ALDOSTERONE
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Zur Isolierung von 18-Aldosteronglucuronid und Tetrahydroaldosteronglucuronid aus menschlichem Urin
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- Authors
- Ulick, S., Kusch, K., & August, J. T.
- Affiliations
- United States Department of Veterans Affairs (US)
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 1961-11
- Volume
- 83
- Issue
- 21
- Pages
- 4482-4483
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2324090553
- Cited by
- 28
- References
- 0
- Citations by year
- 2019: 1
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Chemical Society (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- aldosterone, urinary metabolites, structure correction, steroid metabolism
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