Identification of two C18 oxygenated corticosteroids isolated from human urine
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18-hydroxycorticosterone is converted to 18OHTHA, requiring additional conversion of the 11β-hydroxy group to an 11-keto group by HSD11B2.
“18-hydroxycorticosterone is converted to the tetrahydro metabolite, 18-hydroxy-tetrahydro-11-dehydrocorticosterone (18OHTHA), but this requires the additional conversion of the 11β-hydroxy group to an 11-keto group, a reaction catalyzed by HSD11B2 [[216], [217], [218]].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [217]
Cites
THE DETERMINATION OF 17, 21-DIHYDROXY-20-KETOSTEROIDS IN URINE AND PLASMA
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THE ENZYMATIC REDUCTION OF Δ4-3-KETOSTEROIDS
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The Identification of the Porter-Silber Chromogen Secreted by the Rat Adrenal
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SYNTHESIS OF 18-OXYGENATED PROGESTERONES
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EVIDENCE FOR THE OCCURRENCE OF A METABOLITE OF ALDOSTERONE IN URINE1
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Self-citationSchmidlin, J., Anner, G., Billeter, J. R., et al. (1957) · Helvetica Chimica Acta · doi:10.1002/hlca.19570400729 · Cited by 53 · see citing works
ISOLATION OF 18-HYDROXYDEOXYCORTICOSTERONE FROM RAT ADRENALS1
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THE SYNTHESIS OF ALDOSTERONE FROM PROGESTERONE BY THE AMPHIBIAN ADRENAL1
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Self-citationThe Infrared Spectra of Acetoxysteroids below 1350 Cm.-1
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A simplified blue tetrazolium reaction.
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Stereospecificity in the Metabolism of Aldosterone in Man
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Self-citationCORRECTION OF THE STRUCTURE OF A URINARY METABOLITE OF ALDOSTERONE<sup>1</sup>
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Self-citationExtension of the Porter-Silber Reaction to 17-Deoxyalpha-ketolic Steroids
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17-Hydroxylation deficiency in man
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Schiffer, L., Barnard, L., Baranowski, E. S., Gilligan, L. C., Taylor, A. E., Arlt, W., Shackleton, C. H. L., & Storbeck, K.-H. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105439 · Cited by 450 · see citing works
Shackleton, C. H. L., & Honour, J. W. (1977) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(77)90051-6 · Cited by 31 · see citing works
- Authors
- Ulick, S., & Vetter, K. K.
- Affiliations
- United States Department of Veterans Affairs (US)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1962-11
- Volume
- 237
- Issue
- 11
- Pages
- 3364-3374
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W160954645
- Cited by
- 67
- References
- 29
- Citations by year
- 2023: 1 · 2019: 1
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- human urine, steroid metabolism, urinary steroids
- MeSH terms
- Adrenal Cortex Hormones, Dermatologic Agents, Glucocorticoids, Respiration
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