The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
A Novel Two-Fluorophore Approach to Ratiometric Sensing of Zn2+
Abstract
We present a small molecule ratiometric Zn2+-sensing system based on two fluorophores excited by visible light, a Zn2+-insensitive reporter fluorophore, coumarin 343, and a Zn2+-sensitive fluorescein-based compound, ZPA-1. The two fluorophores are linked by an ester to give Coumazin-1, a membrane-permeable, essentially nonfluorescent compound. Upon exposure to esterases, Coumazin-1 is hydrolyzed to its constituent fluorophores. Measurement of the ratio of coumarin emission at 488 nm (lambdaexc = 445 nm) and comparison with ZPA-1 emission at 534 nm (lambdaexc = 505 nm) affords information about the amount of sensor present as well as the amount of Zn2+ present. A generally applicable synthetic route to amide-functionalized ZP1 sensors is also described. The Zn2+-sensing properties of one member of this class are similar to those of the parent ZP1 sensor, with slightly tighter binding and lower background signal.
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Cites
Signaling Recognition Events with Fluorescent Sensors and Switches
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Self-citationContribution of Aerobic Photoheterotrophic Bacteria to the Carbon Cycle in the Ocean
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ZP4, an Improved Neuronal Zn2+ Sensor of the Zinpyr Family
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Self-citationA Novel, Cell-Permeable, Fluorescent Probe for Ratiometric Imaging of Zinc Ion
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A fluorescent PEBBLE nanosensor for intracellular free zinc
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Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
Que, E. L., Domaille, D. W., & Chang, C. J. (2008) · Chemical Reviews · doi:10.1021/cr078203u · Cited by 2,061
Design Strategies for Water-Soluble Small Molecular Chromogenic and Fluorogenic Probes
Li, X., Gao, X., Shi, W., & Ma, H. (2014) · Chemical Reviews · doi:10.1021/cr300508p · Cited by 1,729
Luminescent sensors and switches in the early 21st century
Callan, J. F., de Silva, A. P., & Magri, D. C. (2005) · Tetrahedron · doi:10.1016/j.tet.2005.05.043 · Cited by 1,123
Synthetic fluorescent sensors for studying the cell biology of metals
Domaille, D. W., Que, E. L., & Chang, C. J. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.69 · Cited by 1,081
Jiang, P., & Guo, Z. (2004) · Coordination Chemistry Reviews · doi:10.1016/j.cct.2003.10.013 · Cited by 989
Metadata
- Authors
- Woodroofe, C. C., & Lippard, S. J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-08-27
- Volume
- 125
- Issue
- 38
- Pages
- 11458-11459
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1993288267
- Cited by
- 259
- References
- 11
- FWCI
- 7.87
- Type
- journal article
- Language
- en
- Open access
- closed
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