The DOI matches its Crossref record.
The Dynamic Character of the G-Quadruplex Element in the c-MYC Promoter and Modification by TMPyP4
Abstract
The nuclease hypersensitivity element III1 (NHE III1) upstream of the P1 and P2 promoters of c-MYC controls 80-90% of the transcriptional activity of this gene. The purine-rich strand in this region can form a G-quadruplex structure that is a critical part of the silencer element for this promoter. We have demonstrated that this G-quadruplex structure can form a mixture of four biologically relevant parallel-loop isomers, which upon interaction with the cationic porphyrin TMPyP4 are converted to mixed parallel/antiparallel G-quadruplex structures.
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Cited by
Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes
Roach, R. J., Garavís, M., González, C., Jameson, G. B., Filichev, V. V., & Hale, T. K. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkz1138 · Cited by 518
Loop-Length-Dependent Folding of G-Quadruplexes
Hazel, P., Huppert, J., Balasubramanian, S., & Neidle, S. (2004) · Journal of the American Chemical Society · doi:10.1021/ja045154j · Cited by 494
Four-stranded nucleic acids: structure, function and targeting of G-quadruplexes
Huppert, J. L. (2008) · Chemical Society Reviews · doi:10.1039/b702491f · Cited by 494
Seenisamy, J., Bashyam, S., Gokhale, V., Vankayalapati, H., Sun, D., Siddiqui-Jain, A., Streiner, N., Shin-ya, K., White, E., Wilson, W. D., et al. (2005) · Journal of the American Chemical Society · doi:10.1021/ja0444482 · Cited by 319
Self-citationBrooks, T. A., & Hurley, L. H. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2733 · Cited by 294
Self-citationThe c‐myc Promoter: Still MysterY and Challenge
(2008) · Advances in Cancer Research · doi:10.1016/s0065-230x(07)99004-1 · Cited by 211
Carabet, L. A., Rennie, P. S., & Cherkasov, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010120 · Cited by 172
Hu, M.-H., Wang, Y.-Q., Yu, Z.-Y., Hu, L.-N., Ou, T.-M., Chen, S.-B., Huang, Z.-S., & Tan, J.-H. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01697 · Cited by 101
Metadata
- Authors
- Seenisamy, J., Rezler, E. M., Powell, T. J., Tye, D., Gokhale, V., Joshi, C. S., Siddiqui-Jain, A., & Hurley, L. H.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-06-22
- Volume
- 126
- Issue
- 28
- Pages
- 8702-8709
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2035667154
- Cited by
- 389
- References
- 0
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- closed
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