The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Self-Assembled Multivalent Pseudopolyrotaxane for Binding Galectin-1
Abstract
A self-assembled pseudopolyrotaxane consisting of lactoside-displaying cyclodextrin (CD) "beads" threaded onto a linear polyviologen "string" was investigated for its ability to inhibit galectin-1-mediated T-cell agglutination. The CDs of the pseudopolyrotaxane are able to spin around the axis of the polymer chain as well as to move back and forth along its backbone to alter the presentation of its ligand. This supramolecular superstructure incorporates all the advantages of polymeric structures, such as the ability to span large distances, along with a distinctively dynamic presentation of its lactoside ligands to afford a neoglycoconjugate that can adjust to the relative stereochemistries of the lectin's binding sites. The pseudopolyrotaxane exhibited a valency-corrected 10-fold enhancement over native lactose in the agglutination assay, which was greater than the enhancements observed for lactoside-bearing trivalent glycoclusters and a lactoside-bearing chitosan polymer tested using the same assay. The experimental results indicate that supramolecular architectures, such as the pseudopolyrotaxane, provide tools for investigating protein-carbohydrate interactions.
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Cites
Brewer, C. (2002) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(02)00364-0 · Cited by 435
Yotsu-Yamashita, M., Haddock, R. L., & Yasumoto, T. (1993) · Journal of the American Chemical Society · doi:10.1021/ja00056a048 · Cited by 125
Cited by
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Multivalent glycoconjugates as anti-pathogenic agents
Bernardi, A., Jiménez-Barbero, J., Casnati, A., De Castro, C., Darbre, T., Fieschi, F., Finne, J., Funken, H., Jaeger, K.-E., Lahmann, M., et al. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35408j · Cited by 537
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Self-citationCombining supramolecular chemistry with biology
Uhlenheuer, D. A., Petkau, K., & Brunsveld, L. (2010) · Chemical Society Reviews · doi:10.1039/b820283b · Cited by 377
de la Fuente, J. M., & Penadés, S. (2006) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2005.12.001 · Cited by 269
Murphy, P., André, S., & Gabius, H.-J. (2013) · Molecules · doi:10.3390/molecules18044026 · Cited by 54
Metadata
- Authors
- Nelson, A., Belitsky, J. M., Vidal, S., Joiner, C. S., Baum, L. G., & Stoddart, J. F.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-09-01
- Volume
- 126
- Issue
- 38
- Pages
- 11914-11922
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2005361208
- Cited by
- 162
- References
- 2
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- closed
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