The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Highly Efficient and Photostable Photosensitizer Based on BODIPY Chromophore
Abstract
Photosensitizers are reagents that produce reactive oxygen species upon light illumination and are commonly used to study oxidative stress or for photodynamic therapy. There are many available photosensitizers, but most have limitations, such as low photostability, structural instability, or a limited usable range of solvent conditions. Here, we describe a novel photosensitizer scaffold (2I-BDP) based on the unique characteristics of the BODIPY chromophore (i.e., high extinction coefficient, high photostability, and insensitivity to solvent environment). 2I-BDP shows stronger near-infrared singlet oxygen luminescence emission and higher photostability than the well-known photosensitizer, Rose Bengal. Unlike other photosensitizers, this scaffold is widely applicable under various conditions, including lipophilic and aqueous environments. HeLa cells loaded with 2I-BDP could be photosensitized by light illumination, demonstrating that 2I-BDP is potentially useful as a reagent for cell photosensitization, oxidative stress studies, or PDT.
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Cites
A Compilation of Singlet Oxygen Yields from Biologically Relevant Molecules
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McClure, D. S. (1949) · The Journal of Chemical Physics · doi:10.1063/1.1747085 · Cited by 787
Gabe, Y., Urano, Y., Kikuchi, K., Kojima, H., & Nagano, T. (2004) · Journal of the American Chemical Society · doi:10.1021/ja037944j · Cited by 668
Self-citationKarolin, J., Johansson, L. B.-A., Strandberg, L., & Ny, T. (1994) · Journal of the American Chemical Society · doi:10.1021/ja00096a042 · Cited by 628
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Cited by
BODIPY Dyes and Their Derivatives: Syntheses and Spectroscopic Properties
Loudet, A., & Burgess, K. (2007) · Chemical Reviews · doi:10.1021/cr078381n · Cited by 5,238
BODIPY dyes in photodynamic therapy
Kamkaew, A., Lim, S. H., Lee, H. B., Kiew, L. V., Chung, L. Y., & Burgess, K. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35216h · Cited by 2,104
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
Triplet photosensitizers: from molecular design to applications
Zhao, J., Wu, W., Sun, J., & Guo, S. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35531d · Cited by 1,579
Photosensitizers with Aggregation‐Induced Emission: Materials and Biomedical Applications
Hu, F., Xu, S., & Liu, B. (2018) · Advanced Materials · doi:10.1002/adma.201801350 · Cited by 859
Metadata
- Authors
- Yogo, T., Urano, Y., Ishitsuka, Y., Maniwa, F., & Nagano, T.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-08-12
- Volume
- 127
- Issue
- 35
- Pages
- 12162-12163
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2095472229
- Cited by
- 853
- References
- 8
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- closed
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