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Cited by 2,104Photodynamic Therapy Research StudiesLuminescence and Fluorescent MaterialsNanoplatforms for cancer theranostics

BODIPY dyes in photodynamic therapy

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Kamkaew, Anyanee, Lim, Siang Hui, Lee, Hong Boon, Kiew, Lik Voon, Chung, Lip Yong, Burgess, Kevin·2013·Chem. Soc. Rev.
DOI 10.1039/c2cs35216hPMC PMC3514588
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Abstract

BODIPY dyes tend to be highly fluorescent, but their emissions can be attenuated by adding substituents with appropriate oxidation potentials. Substituents like these have electrons to feed into photoexcited BODIPYs, quenching their fluorescence, thereby generating relatively long-lived triplet states. Singlet oxygen is formed when these triplet states interact with (3)O(2). In tissues, this causes cell damage in regions that are illuminated, and this is the basis of photodynamic therapy (PDT). The PDT agents that are currently approved for clinical use do not feature BODIPYs, but there are many reasons to believe that this situation will change. This review summarizes the attributes of BODIPY dyes for PDT, and in some related areas.

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  • By using pooled CRISPR-Cas9 targeted screening, we discovered genes for which variants cause autosomal dominant forms of neurodegeneration (SLC33A1, SNX17, GRN, VPS35, CLN3, NPC2) as genetic modulators of lipid droplet formation in microglia.

    “By using pooled CRISPR-Cas9 targeted screening, we discovered genes for which variants cause autosomal dominant forms of neurodegeneration (SLC33A1, SNX17, GRN, VPS35, CLN3, NPC2) as genetic modulators of lipid droplet formation in microglia32–35.”

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Cited by

Sorted by citations

Authors
Kamkaew, A., Lim, S. H., Lee, H. B., Kiew, L. V., Chung, L. Y., & Burgess, K.
Affiliations
  • Texas A&M University (US)
  • University of Malaya (MY)
  • Cancer Research Malaysia (MY)
Corresponding author
Burgess, Kevin
ORCID
Venue
Chem. Soc. Rev.
Publisher
Royal Society of Chemistry (RSC)
Published
2013
Volume
42
Issue
1
Pages
77-88
ISSN
  • 0306-0012 (ISSN-L)
  • 1460-4744
DOI
10.1039/c2cs35216h
PMC
PMC3514588
OpenAlex
W2070789044
Cited by
2,104
References
2
Citations by year
2026: 105 · 2025: 118 · 2024: 151 · 2023: 160 · 2022: 175 · 2021: 213 · 2020: 197 · 2019: 181 · 2018: 183 · 2017: 185 · 2016: 159 · 2015: 119 · 2014: 94 · 2013: 60 · 2012: 1
FWCI
14.92
Type
journal article
Language
en
Open access
Locations
  • Chemical Society Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • The University of Malaya Research Repository (University of Malaya) (acceptedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of General Medical Sciences (R01GM087981, GM087981)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords
BODIPY dyes, photodynamic therapy, fluorescence quenching, triplet state, singlet oxygen, photosensitizers, cell damage
MeSH terms
Boron Compounds, Fluorescent Dyes, Photochemotherapy, Photosensitizing Agents

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