The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Detection of Homocysteine and Cysteine
Open accessAbstract
At elevated levels, homocysteine (Hcy, 1) is a risk factor for cardiovascular diseases, Alzheimer's disease, neural tube defects, and osteoporosis. Both 1 and cysteine (Cys, 3) are linked to neurotoxicity. The biochemical mechanisms by which 1 and 3 are involved in disease states are relatively unclear. Herein, we describe simple methods for detecting either Hcy or Cys in the visible spectral region with the highest selectivity reported to date without using biochemical techniques or preparative separations. Simple methods and readily available reagents allow for the detection of Cys and Hcy in the range of their physiologically relevant levels. New HPLC postcolumn detection methods for biological thiols are reported. The potential biomedical relevance of the chemical mechanisms involved in the detection of 1 is described.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease
Seshadri, S., Beiser, A., Selhub, J., Jacques, P. F., Rosenberg, I. H., D'Agostino, R. B., Wilson, P. W. F., & Wolf, P. A. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011613 · Cited by 3,237
Cited by
Fluorescent and colorimetric probes for detection of thiols
Chen, X., Zhou, Y., Peng, X., & Yoon, J. (2010) · Chemical Society Reviews · doi:10.1039/b925092a · Cited by 1,580
Ratiometric Detection of Mitochondrial Thiols with a Two-Photon Fluorescent Probe
Lim, C. S., Masanta, G., Kim, H. J., Han, J. H., Kim, H. M., & Cho, B. R. (2011) · Journal of the American Chemical Society · doi:10.1021/ja205081s · Cited by 365
Li, H., Fan, J., Wang, J., Tian, M., Du, J., Sun, S., Sun, P., & Peng, X. (2009) · Chemical Communications · doi:10.1039/b907511a · Cited by 339
Non-invasive plant disease diagnostics enabled by smartphone-based fingerprinting of leaf volatiles
Li, Z., Paul, R., Ba Tis, T., Saville, A. C., Hansel, J. C., Yu, T., Ristaino, J. B., & Wei, Q. (2019) · Nature Plants · doi:10.1038/s41477-019-0476-y · Cited by 322
Thiol Reactive Probes and Chemosensors
Peng, H., Chen, W., Cheng, Y., Hakuna, L., Strongin, R., & Wang, B. (2012) · Sensors · doi:10.3390/s121115907 · Cited by 275
Self-citation
Metadata
- Authors
- Wang, W., Rusin, O., Xu, X., Kim, K. K., Escobedo, J. O., Fakayode, S. O., Fletcher, K. A., Lowry, M., Schowalter, C. M., Lawrence, C. M., Fronczek, F. R., Warner, I. M., & Strongin, R. M.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-10-21
- Volume
- 127
- Issue
- 45
- Pages
- 15949-15958
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1988887549
- Cited by
- 593
- References
- 1
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Detection of Homocysteine and Cysteine. https://app.cochat.ai/papers/10.1021/ja054962n
- The paper
- Wang, W., Rusin, O., Xu, X., Kim, K. K., Escobedo, J. O., Fakayode, S. O., Fletcher, K. A., Lowry, M., Schowalter, C. M., Lawrence, C. M., Fronczek, F. R., Warner, I. M., & Strongin, R. M. (2005). Detection of Homocysteine and Cysteine. Journal of the American Chemical Society. https://doi.org/10.1021/ja054962n
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
