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Glutathione-Mediated Delivery and Release Using Monolayer Protected Nanoparticle Carriers
Open accessAbstract
We demonstrate here the effective delivery of a dye payload into cells using 2-nm core gold nanoparticles, with release occurring via place exchange of glutathione onto the particle surface. In vitro experiments demonstrate effective release of drug analogues upon addition of glutathione. Cell culture experiments show rapid uptake of nanoparticle and effective release of payload. The role of glutathione in the release process was demonstrated through improved payload release upon transient increase in glutathione levels achieved via introduction of glutathione ethyl ester into the cell.
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Citations
Cited by
Applications of Nanoparticles in Biology
De, M., Ghosh, P. S., & Rotello, V. M. (2008) · Advanced Materials · doi:10.1002/adma.200703183 · Cited by 1,547
Self-citationA Review on the Synthesis and Functionalization of Gold Nanoparticles as a Drug Delivery Vehicle
Amina, S. J., & Guo, B. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s279094 · Cited by 561
Gold Nanoparticles for Nucleic Acid Delivery
Ding, Y., Jiang, Z., Saha, K., Kim, C. S., Kim, S. T., Landis, R. F., & Rotello, V. M. (2014) · Molecular Therapy · doi:10.1038/mt.2014.30 · Cited by 521
Self-citationDual-Site Fluorescent Probe for Visualizing the Metabolism of Cys in Living Cells
Yue, Y., Huo, F., Ning, P., Zhang, Y., Chao, J., Meng, X., & Yin, C. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.6b12845 · Cited by 499
Luminescent Gold Nanoparticles with Efficient Renal Clearance
Zhou, C., Long, M., Qin, Y., Sun, X., & Zheng, J. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201007321 · Cited by 490
Metadata
- Authors
- Hong, R., Han, G., Fernández, J. M., Kim, B.-J., Forbes, N. S., & Rotello, V. M.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-01-10
- Volume
- 128
- Issue
- 4
- Pages
- 1078-1079
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2035869908
- Cited by
- 817
- References
- 0
- FWCI
- 14.14
- Type
- journal article
- Language
- en
- Open access
- green
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- Hong, R., Han, G., Fernández, J. M., Kim, B.-J., Forbes, N. S., & Rotello, V. M. (2006). Glutathione-Mediated Delivery and Release Using Monolayer Protected Nanoparticle Carriers. Journal of the American Chemical Society. https://doi.org/10.1021/ja056726i
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
