The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Dual-Site Fluorescent Probe for Visualizing the Metabolism of Cys in Living Cells
Abstract
Fluorescent probes, as noninvasive tools for visualizing the metabolism of biomolecules, hold great potential to explore their physiological and pathological processes. For cysteine (Cys), however, none of the reported fluorescent probes could image the metabolic processes in living cells. To achieve this goal, we developed a coumarin derivative based on rational design of the dual recognition sites for Cys and its metabolite, SO 2 . The probe displayed distinct two channels with turn-on fluorescent emission toward Cys and SO 2, which were successfully applied for imaging both A549 cells and zebrafish. Further, with reversible fluorescent responses toward Cys, the probe could image the enzymatic conversion of Cys to SO 2 in living A549 cells in a ratiometric manner. The present work reports the first probe to image the endogenous generated SO 2 without incubation of the SO 2 donors.
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Cites
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Near infrared fluorescent probes for detecting and imaging active small molecules
Ding, C., & Ren, T. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215080 · Cited by 247
Li, H., Yao, Q., Xu, F., Xu, N., Duan, R., Long, S., Fan, J., Du, J., Wang, J., & Peng, X. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.06.028 · Cited by 109
Metadata
- Authors
- Yue, Y., Huo, F., Ning, P., Zhang, Y., Chao, J., Meng, X., & Yin, C.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-02-15
- Volume
- 139
- Issue
- 8
- Pages
- 3181-3185
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2586923067
- Cited by
- 499
- References
- 32
- FWCI
- 30.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yue, Y., Huo, F., Ning, P., Zhang, Y., Chao, J., Meng, X., & Yin, C. (2017). Dual-Site Fluorescent Probe for Visualizing the Metabolism of Cys in Living Cells. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.6b12845
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