The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Using a Kinase/Phosphatase Switch to Regulate a Supramolecular Hydrogel and Forming the Supramolecular Hydrogel in Vivo
Abstract
We have designed and synthesized a new hydrogelator Nap-FFGEY (1), which forms a supramolecular hydrogel. A kinase/phosphatase switch is used to control the phosphorylation and dephosphorylation of the hydrogelator and to regulate the formation of supramolecular hydrogels. Adding a kinase to the hydrogel induces a gel-sol phase transition in the presence of adenosine triphosphates (ATP) because the tyrosine residue is converted into tyrosine phosphate by the kinase to give a more hydrophilic molecule of Nap-FFGEY-P(O)(OH)(2) (2); treating the resulting solution with a phosphatase transforms 2 back to 1 and restores the hydrogel. Electron micrographs of the hydrogels indicate that 1 self-assembles into nanofibers. Subcutaneous injection of 2 in mice shows that 80.5 +/- 1.2% of 2 turns into 1 and results in the formation of the supramolecular hydrogel of 1 in vivo. This simple biomimetic approach for regulating the states of supramolecular hydrogels promises a new way to design and construct biomaterials.
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Cites
Low Molecular Mass Gelators of Organic Liquids and the Properties of Their Gels
Terech, P., & Weiss, R. G. (1997) · Chemical Reviews · doi:10.1021/cr9700282 · Cited by 3,130
Selective Differentiation of Neural Progenitor Cells by High-Epitope Density Nanofibers
Silva, G. A., Czeisler, C., Niece, K. L., Beniash, E., Harrington, D. A., Kessler, J. A., & Stupp, S. I. (2004) · Science · doi:10.1126/science.1093783 · Cited by 2,169
Water Gelation by Small Organic Molecules
Estroff, L. A., & Hamilton, A. D. (2004) · Chemical Reviews · doi:10.1021/cr0302049 · Cited by 2,034
Smith, T. E., & Angstadt, C. N. (2002) · Textbook of Biochemistry · doi:10.1002/0471254959.dev023 · Cited by 1,053
The Assignment of Absolute Configuration by NMR
Seco, J. M., Quiñoá, E., & Riguera, R. (2004) · Chemical Reviews · doi:10.1021/cr000665j · Cited by 983
Sreenivasachary, N., & Lehn, J.-M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501663102 · Cited by 351
Coassembly of Amphiphiles with Opposite Peptide Polarities into Nanofibers
Behanna, H. A., Donners, J. J. J. M., Gordon, A. C., & Stupp, S. I. (2005) · Journal of the American Chemical Society · doi:10.1021/ja044863u · Cited by 313
Proximal protein tyrosine kinases in immunoreceptor signaling
Latour, S., & Veillette, A. (2001) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00219-3 · Cited by 195
NF‐κB activation by protein kinase C isoforms and B‐cell function
Moscat, J., Díaz-Meco, M. T., & Rennert, P. D. (2003) · EMBO Reports · doi:10.1038/sj.embor.embor704 · Cited by 128
Hutton, J. C., & Eisenbarth, G. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1633447100 · Cited by 48
Identification of a fatty acid Δ11‐desaturase from the microalga Thalassiosira pseudonana1
Tonon, T., Harvey, D., Qing, R., Li, Y., Larson, T. R., & Graham, I. A. (2004) · FEBS Letters · doi:10.1016/s0014-5793(04)00241-8 · Cited by 42
Julien, M., Kajiji, S. M., Kaback, R. H., & Gros, P. (1999) · Biochemistry · doi:10.1021/bi991726e · Cited by 17
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Self-citationSupramolecular Hydrogel Exhibiting Four Basic Logic Gate Functions To Fine-Tune Substance Release
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Metadata
- Authors
- Yang, Z., Liang, G., Wang, L., & Xu, B.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-02-10
- Volume
- 128
- Issue
- 9
- Pages
- 3038-3043
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1989873976
- Cited by
- 485
- References
- 12
- FWCI
- 11.87
- Type
- journal article
- Language
- en
- Open access
- closed
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