Switching the adhesive state of catecholic hydrogels using phototitration
Abstract
A polyacrylamide hydrogel system that can be liquefied by remote activation using UV irradiation is investigated as a degradable adhesive. The linear polyacrylamide copolymer, formed by conventional free-radical polymerization, contains biomimetic catechol–iron-mediated cross-linkers that are sensitive to pH changes. Hydrogel films and bulk gels are prepared by basic titration of a polymer solution doped with a photoacid generator, diphenyliodonium chloride, generating an ionic cross-linked network via the catechol pendant groups. Irradiation of these hydrogels with UV light affords a viscous liquid solution, demonstrating a gel–sol transition with a subsequent decrease in the adhesive strength of the material. These gels may be prepared in high throughput and require few synthetic steps with commercially available precursors.
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Unprotected polymerizations of catechol-based monomers have been reported in recent years.
“Even so, unprotected polymerizations of catechol-based monomers have been reported in recent years [56,57].”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [57]
The rational regulation of polymerization conditions, such as polymerization time, monomer concentration, and oxygen-free atmosphere, is important for successful polymerization.
“The rational regulation of polymerization conditions, such as polymerization time, monomer concentration, and oxygen-free atmosphere, was found to be important for successful polymerization [57].”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [57]
Some studies have successfully polymerized catechol-based monomers by tuning polymerization conditions, but the detailed mechanism remains elusive.
“Although some studies have successfully polymerized catechol-based monomers by tuning the polymerization conditions [57], the detailed mechanism is still elusive.”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [57]
Cites
Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties
Kloxin, A. M., Kasko, A. M., Salinas, C. N., & Anseth, K. S. (2009) · Science · doi:10.1126/science.1169494 · Cited by 1,748 · see citing works
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Recent progress in synthesis and application of mussel-inspired adhesives
Guo, Q., Chen, J., Wang, J., Zeng, H., & Yu, J. (2020) · Nanoscale · doi:10.1039/c9nr09780e · Cited by 370 · see citing works
Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications
Dou, W., Zeng, X., Zhu, S., Zhu, Y., Liu, H., & Li, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169100 · Cited by 52 · see citing works
“…regulation of polymerization conditions, such as polymerization time, monomer concentration, and oxygen-free atmosphere, was found to be important for successful polymerization [57]. monomer concentration, and oxygen-free atmosphere, was found to be important for successful polymerization [57].”
BackgroundAn injectable, robust double network adhesive hydrogel for efficient, real-time hemostatic sealing
Zhang, W., Song, S., Huang, J., & Zhang, Z. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.146244 · Cited by 34 · see citing works
- Authors
- White, E. M., Seppala, J. E., Rushworth, P. M., Ritchie, B. W., Sharma, S., & Locklin, J.
- Affiliations
- University of Georgia (US)
- National Institute of Standards and Technology (US)
- Corresponding author
- Locklin, Jason
- ORCID
- Venue
- Macromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-11-19
- Volume
- 46
- Issue
- 22
- Pages
- 8882-8887
- ISSN
- 0024-9297 (ISSN-L)
- 1520-5835
- OpenAlex
- W2315719202
- Cited by
- 58
- References
- 1
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 12 · 2017: 7 · 2016: 5 · 2015: 8 · 2014: 5
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Macromolecules (publishedVersion)
- Funders
- National Science Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Chemistry › Organic Chemistry › Photopolymerization techniques and applications
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Keywords
- polyacrylamide hydrogel, photoacid generator, diphenyliodonium chloride, UV irradiation, gel-sol transition, adhesion strength
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