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Cited by 434

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

An Improved Class of Sugar-Binding Boronic Acids, Soluble and Capable of Complexing Glycosides in Neutral Water

Dowlut, Meenakshi, Hall, Dennis G.·2006·Journal of the American Chemical Society

Abstract

This study describes a new class of carbohydrate-binding boronic acids. ortho-Hydroxymethyl phenylboronic acid (boronophthalide) was shown to be superior to the well-established dialkylamino ("Wulff-type") analogues, and it is more soluble in aqueous solvents. The most significant finding in this work is the surprising ability of ortho-hydroxyalkyl arylboronic acids to complex model glycopyranosides under physiologically relevant conditions. These boronic acid units appear to complex hexopyranosides mainly using their 4,6-diol. This behavior is significant because a majority of cell-surface glycoconjugates present free 4,6-diols. Thus, conjugatable forms of these boronic acids could be used in the design of oligomeric receptors and sensors to exploit multivalency effects. Such receptors could dramatically expand the potential of boronic acids toward the selective recognition of cell-surface glycoconjugates.

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Crossref · 10.1021/ja057798c

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Metadata

Authors
Dowlut, M., & Hall, D. G.
Venue
Journal of the American Chemical Society
Published
2006-03-15
Volume
128
Issue
13
Pages
4226-4227
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
OpenAlex
W2037667906
Cited by
434
References
6
FWCI
9.97
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.