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Quantum-Dot/Aptamer-Based Ultrasensitive Multi-Analyte Electrochemical Biosensor
Abstract
The coupling of aptamers with the coding and amplification features of inorganic nanocrystals is shown for the first time to offer a highly sensitive and selective simultaneous bioelectronic detection of several protein targets. This is accomplished in a single-step displacement assay in connection to a self-assembled monolayer of several thiolated aptamers conjugated to proteins carrying different inorganic nanocrystals. Electrochemical stripping detection of the nondisplaced nanocrystal tracers results in a remarkably low (attomole) detection limit, that is, significantly lower than those of existing aptamer biosensors. The new device offers great promise for measuring a large panel of disease markers present at ultralow levels during early stages of the disease progress.
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Citations
Cited by
Electronic Aptamer‐Based Sensors
Willner, I., & Zayats, M. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200604524 · Cited by 818
Applications of Aptamers as Sensors
Cho, E. J., Lee, J.-W., & Ellington, A. D. (2009) · Annual Review of Analytical Chemistry · doi:10.1146/annurev.anchem.1.031207.112851 · Cited by 788
Wongkaew, N., Simsek, M., Griesche, C., & Baeumner, A. J. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00172 · Cited by 657
Wang, F., Lu, C.-H., & Willner, I. (2014) · Chemical Reviews · doi:10.1021/cr400354z · Cited by 649
The Chemical Biology of Aptamers
Mayer, G. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200804643 · Cited by 592
Metadata
- Authors
- Hansen, J. A., Wang, J., Kawde, A.-N., Xiang, Y., Gothelf, K. V., & Collins, G.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-01-26
- Volume
- 128
- Issue
- 7
- Pages
- 2228-2229
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1975860847
- Cited by
- 538
- References
- 0
- FWCI
- 16.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hansen, J. A., Wang, J., Kawde, A.-N., Xiang, Y., Gothelf, K. V., & Collins, G. (2006). Quantum-Dot/Aptamer-Based Ultrasensitive Multi-Analyte Electrochemical Biosensor. Journal of the American Chemical Society. https://doi.org/10.1021/ja060005h
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
