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A Highly Selective Fluorescent Probe for the Detection and Imaging of Peroxynitrite in Living Cells
Abstract
We have found a specific reaction between ketone 1 and peroxynitrite (ONOO-), rather than other reactive oxygen species and reactive nitrogen species generated in the biological system. On the basis of this reaction, we have successfully developed a new fluorescent probe HKGreen-1, which is highly selective for the detection of peroxynitrite in living cells. Before the oxidation with peroxynitrite, the dichlorofluorescein part is masked and the probe is nonfluorescent. However, upon reaction with peroxynitrite, the fluorophore is released, resulting in strong enhancement in fluorescence intensity.
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Citations
Cited by
Chemistry and biology of reactive oxygen species in signaling or stress responses
Dickinson, B. C., & Chang, C. J. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.607 · Cited by 1,821
BODIPY-based probes for the fluorescence imaging of biomolecules in living cells
Kowada, T., Maeda, H., & Kikuchi, K. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00030k · Cited by 1,381
Fluorescent and luminescent probes for detection of reactive oxygen and nitrogen species
Chen, X., Tian, X., Shin, I., & Yoon, J. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15037e · Cited by 980
Chemical biology of peroxynitrite: Kinetics, diffusion, and radicals
Ferrer-Sueta, G., & Radi, R. (2009) · ACS Chemical Biology · doi:10.1021/cb800279q · Cited by 776
Redox Signaling by Reactive Electrophiles and Oxidants
Parvez, S., Long, M. J. C., Poganik, J. R., & Aye, Y. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00698 · Cited by 359
Metadata
- Authors
- Yang, D., Wang, H.-L., Sun, Z.-N., Chung, N.-W., & Shen, J.-G.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-04-14
- Volume
- 128
- Issue
- 18
- Pages
- 6004-6005
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2081298587
- Cited by
- 282
- References
- 0
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yang, D., Wang, H.-L., Sun, Z.-N., Chung, N.-W., & Shen, J.-G. (2006). A Highly Selective Fluorescent Probe for the Detection and Imaging of Peroxynitrite in Living Cells. Journal of the American Chemical Society. https://doi.org/10.1021/ja0603756
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