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Cited by 359

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Redox Signaling by Reactive Electrophiles and Oxidants

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Parvez, Saba, Long, Marcus J. C., Poganik, Jesse R., Aye, Yimon·2018·Chemical Reviews
DOI 10.1021/acs.chemrev.7b00698
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Abstract

The concept of cell signaling in the context of nonenzyme-assisted protein modifications by reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely complex topic that has been approached from numerous different and multidisciplinary angles. Our Review reflects on five aspects critical for understanding how nature harnesses these noncanonical post-translational modifications to coordinate distinct cellular activities: (1) specific players and their generation, (2) physicochemical properties, (3) mechanisms of action, (4) methods of interrogation, and (5) functional roles in health and disease. Emphasis is primarily placed on the latest progress in the field, but several aspects of classical work likely forgotten/lost are also recollected. For researchers with interests in getting into the field, our Review is anticipated to function as a primer. For the expert, we aim to stimulate thought and discussion about fundamentals of redox signaling mechanisms and nuances of specificity/selectivity and timing in this sophisticated yet fascinating arena at the crossroads of chemistry and biology.

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Metadata

Authors
Parvez, S., Long, M. J. C., Poganik, J. R., & Aye, Y.
Venue
Chemical Reviews
Publisher
American Chemical Society (ACS)
Published
2018-08-27
Volume
118
Issue
18
Pages
8798-8888
ISSN
  • 0009-2665 (ISSN-L)
  • 1520-6890
DOI
10.1021/acs.chemrev.7b00698
OpenAlex
W2889257276
Cited by
359
References
1,075
FWCI
2.45
Type
journal article
Language
en
Open access
green
Funders
  • Howard Hughes Medical Institute
  • Division of Chemistry (CHE-1351400)
  • American Heart Association (17PRE33670395)
  • Alfred P. Sloan Foundation (FG-2016-6379)
  • Arnold and Mabel Beckman Foundation
  • Office of Naval Research (N00014-17-1-2529)
  • National Institute of General Medical Sciences (1DP2GM114850)
  • Pershing Square Sohn Cancer Research Alliance

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CoChat. (2026). Citation check: Redox Signaling by Reactive Electrophiles and Oxidants. https://app.cochat.ai/papers/10.1021/acs.chemrev.7b00698
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Parvez, S., Long, M. J. C., Poganik, J. R., & Aye, Y. (2018). Redox Signaling by Reactive Electrophiles and Oxidants. Chemical Reviews. https://doi.org/10.1021/acs.chemrev.7b00698

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