The DOI matches its Crossref record.
TOTAPOL: A Biradical Polarizing Agent for Dynamic Nuclear Polarization Experiments in Aqueous Media
Abstract
In a previous publication, we described the use of biradicals, in that case two TEMPO molecules tethered by an ethylene glycol chain of variable length, as polarizing agents for microwave driven dynamic nuclear polarization (DNP) experiments. The use of biradicals in place of monomeric paramagnetic centers such as TEMPO yields enhancements that are a factor of approximately 4 larger (epsilon approximately 175 at 5 T and 90 K) and concurrently the concentration of the polarizing agent is a factor of 4 smaller (10 mM electron spins), reducing the residual electron nuclear dipole broadening. In this paper we describe the synthesis and characterization by EPR and DNP/NMR of an improved polarizing agent 1-(TEMPO-4-oxy)-3-(TEMPO-4-amino)propan-2-ol (TOTAPOL). Under the same experimental conditions and using 2.5 mm magic angle rotors, this new biradical yields larger enhancements (epsilon approximately 290) at lower concentrations (6 mM electron spins) and has the additional important property that it is compatible with experiments in aqueous media, including salt solutions commonly used in the study of proteins and nucleic acids.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Surface Enhanced NMR Spectroscopy by Dynamic Nuclear Polarization
Lesage, A., Lelli, M., Gajan, D., Caporini, M. A., Vitzthum, V., Miéville, P., Alauzun, J., Roussey, A., Thieuleux, C., Mehdi, A., et al. (2010) · Journal of the American Chemical Society · doi:10.1021/ja104771z · Cited by 585
Dynamic nuclear polarization for sensitivity enhancement in modern solid-state NMR
Lilly Thankamony, A. S., Wittmann, J. J., Kaushik, M., & Corzilius, B. (2017) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/j.pnmrs.2017.06.002 · Cited by 544
Highly Efficient, Water‐Soluble Polarizing Agents for Dynamic Nuclear Polarization at High Frequency
Sauvée, C., Rosay, M., Casano, G., Aussenac, F., Weber, R. T., Ouari, O., & Tordo, P. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201304657 · Cited by 503
Thurber, K. R., & Tycko, R. (2012) · The Journal of Chemical Physics · doi:10.1063/1.4747449 · Cited by 263
Sensitivity-enhanced solid-state NMR detection of expansin’s target in plant cell walls
Wang, T., Park, Y. B., Caporini, M. A., Rosay, M., Zhong, L., Cosgrove, D. J., & Hong, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316290110 · Cited by 234
Mentink-Vigier, F., Marin-Montesinos, I., Jagtap, A. P., Halbritter, T., van Tol, J., Hediger, S., Lee, D., Sigurdsson, S. T., & De Paëpe, G. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b04911 · Cited by 171
Takahashi, H., Ayala, I., Bardet, M., De Paëpe, G., Simorre, J.-P., & Hediger, S. (2013) · Journal of the American Chemical Society · doi:10.1021/ja312501d · Cited by 149
Chow, W. Y., De Paëpe, G., & Hediger, S. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c01043 · Cited by 87
Topology of Pretreated Wood Fibers Using Dynamic Nuclear Polarization
Viger-Gravel, J., Lan, W., Pinon, A. C., Berruyer, P., Emsley, L., Bardet, M., & Luterbacher, J. (2019) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.9b09272 · Cited by 38
Costello, W. N., Xiao, Y., Mentink-Vigier, F., Kragelj, J., & Frederick, K. K. (2024) · Journal of Biomolecular NMR · doi:10.1007/s10858-024-00436-9 · Cited by 16
Metadata
- Authors
- Song, C., Hu, K.-N., Joo, C.-G., Swager, T. M., & Griffin, R. G.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-08-16
- Volume
- 128
- Issue
- 35
- Pages
- 11385-11390
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2065265087
- Cited by
- 550
- References
- 0
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
