The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Carbon Nanotube Amplification Strategies for Highly Sensitive Immunodetection of Cancer Biomarkers
Open accessAbstract
We describe herein the combination of electrochemical immunosensors using single-wall carbon nanotube (SWNT) forest platforms with multi-label secondary antibody-nanotube bioconjugates for highly sensitive detection of a cancer biomarker in serum and tissue lysates. Greatly amplified sensitivity was attained by using bioconjugates featuring horseradish peroxidase (HRP) labels and secondary antibodies (Ab(2)) linked to carbon nanotubes (CNT) at high HRP/Ab(2) ratio. This approach provided a detection limit of 4 pg mL(-)(1) (100 amol mL(-)(1)), for prostate specific antigen (PSA) in 10 microL of undiluted calf serum, a mass detection limit of 40 fg. Accurate detection of PSA in human serum samples was demonstrated by comparison to standard ELISA assays. PSA was quantitatively measured in prostate tissue samples for which PSA could not be differentiated by the gold standard immunohistochemical staining method. These easily fabricated SWNT immunosensors show excellent promise for clinical screening of cancer biomarkers and point-of-care diagnostics.
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Cites
Reverse engineering of biological complexity
Csete, M. E., & Doyle, J. C. (2002) · Science · doi:10.1126/science.1069981 · Cited by 1,215
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Advanced Carbon Electrode Materials for Molecular Electrochemistry
McCreery, R. L. (2008) · Chemical Reviews · doi:10.1021/cr068076m · Cited by 2,729
Carbon nanotubes: properties, synthesis, purification, and medical applications
Eatemadi, A., Daraee, H., Karimkhanloo, H., Kouhi, M., Zarghami, N., Akbarzadeh, A., Abasi, M., Hanifehpour, Y., & Joo, S. W. (2014) · Nanoscale Research Letters · doi:10.1186/1556-276x-9-393 · Cited by 1,239
Mani, V., Chikkaveeraiah, B. V., Patel, V., Gutkind, J. S., & Rusling, J. F. (2009) · ACS Nano · doi:10.1021/nn800863w · Cited by 532
Self-citationDu, D., Zou, Z., Shin, Y., Wang, J., Wu, H., Engelhard, M. H., Liu, J., Aksay, I. A., & Lin, Y. (2010) · Analytical Chemistry · doi:10.1021/ac100036p · Cited by 448
Point of care testing: The impact of nanotechnology
Syedmoradi, L., Daneshpour, M., Alvandipour, M., Gomez, F. A., Hajghassem, H., & Omidfar, K. (2017) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.08.084 · Cited by 367
Malhotra, R., Patel, V., Vaqué, J. P., Gutkind, J. S., & Rusling, J. F. (2010) · Analytical Chemistry · doi:10.1021/ac902802b · Cited by 361
Self-citationFunctionalized carbon nanotubes and nanofibers for biosensing applications
Wang, J., & Lin, Y. (2008) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2008.05.009 · Cited by 289
Noninvasive ovarian cancer biomarker detection via an optical nanosensor implant
Williams, R. M., Lee, C., Galassi, T. V., Harvey, J. D., Leicher, R., Sirenko, M., Dorso, M. A., Shah, J., Olvera, N., Dao, F., et al. (2018) · Science Advances · doi:10.1126/sciadv.aaq1090 · Cited by 183
Metadata
- Authors
- Yu, X., Munge, B., Patel, V., Jensen, G., Bhirde, A., Gong, J. D., Kim, S. N., Gillespie, J., Gutkind, J. S., Papadimitrakopoulos, F., & Rusling, J. F.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-08-01
- Volume
- 128
- Issue
- 34
- Pages
- 11199-11205
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1980866775
- Cited by
- 686
- References
- 1
- FWCI
- 38.46
- Type
- journal article
- Language
- en
- Open access
- green
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