Noninvasive ovarian cancer biomarker detection via an optical nanosensor implant
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Ovarian cancer biomarker detection using a novel nanosensor implant in live mice.
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The emission of SWCNTs (E11) is sensitive to dielectric environments, redox perturbations and electrostatic charge.
“The emission of SWCNTs (E11) is sensitive to dielectric environments21,22, redox perturbations23 and electrostatic charge24,25.”
From Detection of ovarian cancer via the spectral fingerprinting of quantum-defect-modified carbon nanotubes in serum by machine learning (2022) · cites this paper as [25]
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Self-citationNanoreporter Identifies Lysosomal Storage Disease Lipid Accumulation Intracranially
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- Authors
- Williams, R. M., Lee, C., Galassi, T. V., Harvey, J. D., Leicher, R., Sirenko, M., Dorso, M. A., Shah, J., Olvera, N., Dao, F., Levine, D. A., & Heller, D. A.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Tri-Institutional PhD Program in Chemical Biology (US)
- NYU Langone Health (US)
- Corresponding author
- Heller, Daniel A.
- ORCID
- Venue
- Science Advances
- Published
- 2018-04-06
- Volume
- 4
- Issue
- 4
- Pages
- eaaq1090-eaaq1090
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC5906074
- OpenAlex
- W2801617804
- Cited by
- 183
- References
- 58
- Citations by year
- 2026: 22 · 2025: 19 · 2024: 26 · 2023: 23 · 2022: 27 · 2021: 19 · 2020: 22 · 2019: 20 · 2018: 5
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Science Advances (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (New Innovator Award (DP2-HD075698), Cancer Center Support Grant (P30 CA008748))
- U.S. Department of Defense (W81XWH-11-2-0230 and W81XWH-15-1-0429)
- American Heart Association (Postdoctoral Fellowship (17POST33650043))
- Honorable Tina Brozman Foundation
- Memorial Sloan-Kettering Cancer Center
- Frank A. Howard Scholars Program
- Alan and Sandra Gerry Metastasis Research Initiative
- Louis V. Gerstner Jr Young Investigator’s Fund
- Frank Lappin Horsfall Jr, Fellowship
- Ovarian Cancer Research Fund (Ann Schreiber Mentored Investigator Award 370463)
- Hunter R. Rawlings III Cornell Presidential Research Scholars program
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Keywords
- high-grade serous ovarian cancer, HE4, CA125, optical nanosensors, implantable sensors, carbon nanotubes, non-invasive cancer detection, early cancer detection, orthotopic tumor model, in vivo optical imaging, biomarker detection
- MeSH terms
- Animals, Disease Models, Animal, Female, Humans, Neoplasm Staging, Ovarian Neoplasms, Biomarkers, Tumor, Biosensing Techniques, Cystadenocarcinoma, Serous, Nanotechnology, Mice, Optical Devices, Neoplasm Grading
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