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Hybrid Gadolinium Oxide Nanoparticles: Multimodal Contrast Agents for in Vivo Imaging
Open accessAbstract
Luminescent hybrid nanoparticles with a paramagnetic Gd2O3 core were applied as contrast agents for both in vivo fluorescence and magnetic resonance imaging. These hybrid particles were obtained by encapsulating Gd2O3 cores within a polysiloxane shell which carries organic fluorophores and carboxylated PEG covalently tethered to the inorganic network. Longitudinal proton relaxivities of these particles are higher than the positive contrast agents like Gd-DOTA which are commonly used for clinical magnetic resonance imaging. Moreover these particles can be followed up by fluorescence imaging. This study revealed that these particles suited for dual modality imaging freely circulate in the blood vessels without undesirable accumulation in lungs and liver.
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Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems
Nasongkla, N., Bey, E., Ren, J., Ai, H., Khemtong, C., Guthi, J. S., Chin, S.-F., Sherry, A. D., Boothman, D. A., & Gao, J. (2006) · Nano Letters · doi:10.1021/nl061412u · Cited by 1,238
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Laser Synthesis and Processing of Colloids: Fundamentals and Applications
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Louie, A. (2010) · Chemical Reviews · doi:10.1021/cr9003538 · Cited by 1,044
Nanoparticulate Functional Materials
Goesmann, H., & Feldmann, C. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200903053 · Cited by 733
‘Two is better than one’—probes for dual-modality molecular imaging
Jennings, L. E., & Long, N. J. (2009) · Chemical Communications · doi:10.1039/b821903f · Cited by 438
van Schooneveld, M. M., Vucic, E., Koole, R., Zhou, Y., Stocks, J., Cormode, D. P., Tang, C. Y., Gordon, R. E., Nicolay, K., Meijerink, A., et al. (2008) · Nano Letters · doi:10.1021/nl801596a · Cited by 256
Metadata
- Authors
- Bridot, J.-L., Faure, A.-C., Laurent, S., Rivière, C., Billotey, C., Hiba, B., Janier, M., Josserand, V., Coll, J.-L., Vander Elst, L., Muller, R., Roux, S., Perriat, P., & Tillement, O.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-03-31
- Volume
- 129
- Issue
- 16
- Pages
- 5076-5084
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2012331414
- Cited by
- 766
- References
- 1
- FWCI
- 25.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Bridot, J.-L., Faure, A.-C., Laurent, S., Rivière, C., Billotey, C., Hiba, B., Janier, M., Josserand, V., Coll, J.-L., Vander Elst, L., Muller, R., Roux, S., Perriat, P., & Tillement, O. (2007). Hybrid Gadolinium Oxide Nanoparticles: Multimodal Contrast Agents for in Vivo Imaging. Journal of the American Chemical Society. https://doi.org/10.1021/ja068356j
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