The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Noninvasive Remote-Controlled Release of Drug Molecules in Vitro Using Magnetic Actuation of Mechanized Nanoparticles
Open accessAbstract
Mesoporous silica nanoparticles are useful nanomaterials that have demonstrated the ability to contain and release cargos with mediation by gatekeepers. Magnetic nanocrystals have the ability to exhibit hyperthermic effects when placed in an oscillating magnetic field. In a system combining these two materials and a thermally sensitive gatekeeper, a unique drug delivery system can be produced. A novel material that incorporates zinc-doped iron oxide nanocrystals within a mesoporous silica framework that has been surface-modified with pseudorotaxanes is described. Upon application of an AC magnetic field, the nanocrystals generate local internal heating, causing the molecular machines to disassemble and allowing the cargos (drugs) to be released. When breast cancer cells (MDA-MB-231) were treated with doxorubicin-loaded particles and exposed to an AC field, cell death occurred. This material promises to be a noninvasive, externally controlled drug delivery system with cancer-killing properties.
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Cites
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Mesoporous Materials for Drug Delivery
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Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery
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Self-citationArtificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging
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Self-citationLai, C.-Y., Trewyn, B. G., Jeftinija, D. M., Jeftinija, K., Xu, S., Jeftinija, S., & Lin, V. S.-Y. (2003) · Journal of the American Chemical Society · doi:10.1021/ja028650l · Cited by 1,678
Photocontrolled reversible release of guest molecules from coumarin-modified mesoporous silica
Mal, N. K., Fujiwara, M., & Tanaka, Y. (2003) · Nature · doi:10.1038/nature01362 · Cited by 1,094
Size-Sorted Anionic Iron Oxide Nanomagnets as Colloidal Mediators for Magnetic Hyperthermia
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Mesoporous Silica Nanoparticles as a Delivery System for Hydrophobic Anticancer Drugs
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Self-citationGiri, S., Trewyn, B. G., Stellmaker, M. P., & Lin, V. S. ‐. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200501819 · Cited by 997
Mechanically interlocked molecules incorporating cucurbituril and their supramolecular assemblies
Kim, K. (2002) · Chemical Society Reviews · doi:10.1039/a900939f · Cited by 996
Cited by
Stimuli-responsive nanocarriers for drug delivery
Mura, S., Nicolas, J., & Couvreur, P. (2013) · Nature Materials · doi:10.1038/nmat3776 · Cited by 6,289
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
Mesoporous silica nanoparticles in biomedical applications
Li, Z., Barnes, J. C., Bosoy, A., Stoddart, J. F., & Zink, J. I. (2012) · Chemical Society Reviews · doi:10.1039/c1cs15246g · Cited by 1,907
Self-citationMesoporous Silica Nanoparticles for Drug Delivery
Manzano, M., & Vallet‐Regí, M. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201902634 · Cited by 939
Croissant, J. G., Fatieiev, Y., Almalik, A., & Khashab, N. M. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201700831 · Cited by 594
Metadata
- Authors
- Thomas, C. R., Ferris, D. P., Lee, J.-H., Choi, E., Cho, M. H., Kim, E. S., Stoddart, J. F., Shin, J.-S., Cheon, J., & Zink, J. I.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-07-16
- Volume
- 132
- Issue
- 31
- Pages
- 10623-10625
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1970034438
- Cited by
- 615
- References
- 37
- FWCI
- 19.04
- Type
- journal article
- Language
- en
- Open access
- green
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- Thomas, C. R., Ferris, D. P., Lee, J.-H., Choi, E., Cho, M. H., Kim, E. S., Stoddart, J. F., Shin, J.-S., Cheon, J., & Zink, J. I. (2010). Noninvasive Remote-Controlled Release of Drug Molecules in Vitro Using Magnetic Actuation of Mechanized Nanoparticles. Journal of the American Chemical Society. https://doi.org/10.1021/ja1022267
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