Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging
Open accessAbstract
Successful development of ultra-sensitive molecular imaging nanoprobes for the detection of targeted biological objects is a challenging task. Although magnetic nanoprobes have the potential to perform such a role, the results from probes that are currently available have been far from optimal. Here we used artificial engineering approaches to develop innovative magnetic nanoprobes, through a process that involved the systematic evaluation of the magnetic spin, size and type of spinel metal ferrites. These magnetism-engineered iron oxide (MEIO) nanoprobes, when conjugated with antibodies, showed enhanced magnetic resonance imaging (MRI) sensitivity for the detection of cancer markers compared with probes currently available. Also, we successfully visualized small tumors implanted in a mouse. Such high-performance, nanotechnology-based molecular probes could enhance the ability to visualize other biological events critical to diagnostics and therapeutics.
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MRI has a spatial resolution of 25-50 μm but requires a significant amount of magnetic dye treatment of transplanted cells, has limited sensitivity, and requires considerably complex and expensive equipment.
“MRI is a useful technique for visualizing transplanted cells in vivo and has a spatial resolution of 25–50 μm but requires a significant amount of magnetic dye treatment of transplanted cells, has limited sensitivity, and requires considerably complex and expensive equipment (Lee et al., 2007; Lyons, 2005”
From Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis (2008) · cites this paper as Lee et al., 2007
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- Authors
- Lee, J.-H., Huh, Y.-M., Jun, Y.-W., Seo, J.-W., Jang, J.-T., Song, H.-T., Kim, S., Cho, E.-J., Yoon, H.-G., Suh, J.-S., & Cheon, J.
- Affiliations
- Yonsei University (KR)
- Corresponding author
- Suh, Jin-Suck
- Cheon, Jinwoo
- Venue
- Nature Medicine
- Published
- 2006-12-24
- Volume
- 13
- Issue
- 1
- Pages
- 95-99
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1965686857
- Cited by
- 1,897
- References
- 0
- Citations by year
- 2026: 31 · 2025: 37 · 2024: 63 · 2023: 49 · 2022: 72 · 2021: 104 · 2020: 86 · 2019: 96 · 2018: 89 · 2017: 81 · 2016: 104 · 2015: 109 · 2014: 138 · 2013: 148 · 2012: 128
- FWCI
- 60.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.nature.com
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Materials Science › Materials Chemistry › Magnetic Properties and Synthesis of Ferrites
- Physical Sciences › Materials Science › Materials Chemistry › Lanthanide and Transition Metal Complexes
- Keywords
- magnetic nanoparticles, MRI contrast agents, tumor imaging, molecular imaging
- MeSH terms
- Trastuzumab, Animals, Antibodies, Monoclonal, Cell Line, Female, Ferric Compounds, HeLa Cells, Humans, Magnetic Resonance Imaging, Magnetics, Mice, Inbred BALB C, Mice, Nude, Neoplasms, Neoplasms, Experimental, Sensitivity and Specificity, Biomarkers, Tumor, Reproducibility of Results, Erb-b2 Receptor Tyrosine Kinases, Nanotechnology, Cell Line, Tumor, Mice, Nanoparticles, Antibodies, Monoclonal, Humanized
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