Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A
Butler, Kyle V., Kalin, Jay, Brochier, Camille, Vistoli, Guilio, Langley, Brett, Kozikowski, Alan P.·2010·Journal of the American Chemical Society
Cited by (902)
Items 401–500 of 902
- Cognitive Enhancers (Nootropics). Part 2: Drugs Interacting with Enzymes. Update 2014Wolfgang Froestl, Andreas Muhs, Andrea Pfeifer · 2014 · Journal of Alzheimer s Disease
- A seasonal switch in histone deacetylase gene expression in the hypothalamus and their capacity to modulate nuclear signaling pathwaysPatrick N. Stoney, Diana Rodrigues, Gisela Helfer, Thabat Khatib, Anna Ashton, Elizabeth A. Hay, Robert Starr, Dagmara Kociszewska, Peter J. Morgan, Peter J. A. McCaffery · 2016 · Brain Behavior and Immunity
- Structural and energetic basis for the inhibitory selectivity of both catalytic domains of dimeric HDAC6Yudibeth Sixto‐López, Martiniano Bello, José Correa‐Basurto · 2018 · Journal of Biomolecular Structure and Dynamics
- Stabilization of primary cilia reduces abortive cell cycle re-entry to protect injured adult CNS neurons from apoptosisBrian Choi, Philippe M. D’Onofrio, Alireza P. Shabanzadeh, Paulo D. Koeberle · 2019 · PLoS ONE
- Inhibition of HDAC6 by tubastatin A disrupts mouse oocyte meiosis via regulating histone modifications and mRNA expressionLiyan Sui, Rong Huang, Hao Yu, Sheng Zhang, Ziyi Li · 2020 · Journal of Cellular Physiology
- Ir-Catalyzed Asymmetric Tandem Allylation/Iso-Pictet–Spengler Cyclization Reaction for the Enantioselective Construction of Tetrahydro-γ-carbolinesFan Xiao, Shiming Xu, Xiu‐Qin Dong, Chun‐Jiang Wang · 2021 · Organic Letters
- HDAC6 Inhibition Corrects Electrophysiological and Axonal Transport Deficits in a Human Stem Cell‐Based Model of Charcot‐Marie‐Tooth Disease (Type 2D)Alec S.T. Smith, Jong Hyun Kim, Changho Chun, Ava Gharai, Hyo Won Moon, Eun Young Kim, Soo Hyun Nam, Nina Ha, Ju Young Song, Ki Wha Chung et al. · 2021 · Advanced Biology
- A novel HDAC inhibitor with a hydroxy-pyrimidine scaffoldMelissa M. Kemp, Qiu Wang, Jason H. Fuller, Nathan H. West, Nicole M. Martínez, Elizabeth M. Morse, Michel Weïwer, Stuart L. Schreiber, James E. Bradner, Angela N. Koehler · 2011 · Bioorganic & Medicinal Chemistry Letters
- Histone Deacetylase Inhibition Restores Retinal Pigment Epithelium Function in HyperglycemiaDanielle M. Desjardins, Yueying Liu, Craig E. Crosson, Zsolt Ablonczy · 2016 · PLoS ONE
- Role of histone deacetylase inhibitors in non-neoplastic diseasesChunxiao Zhou, Dengke Zhao, Chunyan Wu, Zhimin Wu, Wen Zhang, Shilv Chen, Xindong Zhao, Shao-Ling Wu · 2024 · Heliyon
- Preclinical Evaluation of an 18F-Labeled SW-100 Derivative for PET Imaging of Histone Deacetylase 6 in the BrainTetsuro Tago, Jun Toyohara, Kenji Ishii · 2021 · ACS Chemical Neuroscience
- Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF PathophysiologySimona Barone, Emilia Cassese, Antonella Ilenia Alfano, Margherita Brindisi, Vincenzo Summa · 2022 · Journal of Medicinal Chemistry
- α-Tubulin detyrosination links the suppression of MCAK activity with taxol cytotoxicityDanilo Lopes, Alexandre L. Seabra, Bernardo Orr, Hélder Maiato · 2022 · The Journal of Cell Biology
- Discovery of the First Irreversible HDAC6 Isoform Selective Inhibitor with Potent Anti-Multiple Myeloma ActivityFengling Liu, Chunxi Liu, Qipeng Chai, Chunlong Zhao, Hongwei Meng, Xue Xia, Tso‐Pang Yao, Yingjie Zhang · 2023 · Journal of Medicinal Chemistry
- Tackling triple negative breast cancer with HDAC inhibitors: 6 is the isoform!Anna Guadagni, Simona Barone, Antonella Ilenia Alfano, Sveva Pelliccia, Ivana Bello, Elisabetta Panza, Vincenzo Summa, Margherita Brindisi · 2024 · European Journal of Medicinal Chemistry
- Novel histone deacetylase 8 ligands without a zinc chelating group: Exploring an ‘upside-down’ binding poseAditya Sudheer Vaidya, Raghupathi Neelarapu, Antonett Madriaga, He Bai, Emma L. Mendonca, Hazem Abdelkarim, Richard Bruce van Breemen, Sylvie Y. Blond, Pavel A. Petukhov · 2012 · Bioorganic & Medicinal Chemistry Letters
- A Decade of the Human Genome Sequence—How Does the Medicinal Chemist Benefit?Andreas Brunschweiger, Jonathan Hall · 2011 · ChemMedChem
- Phenylpyrrole-Based Hdac Inhibitors: Synthesis, Molecular Modeling and Biological StudiesMargherita Brindisi, Caterina Cavella, Simone Brogi, Angela Nebbioso, Johanna Senger, Samuele Maramai, Alfonso Ciotta, Concetta Iside, Stefania Butini, Stefania Lamponi et al. · 2016 · Future Medicinal Chemistry
- Design and synthesis of benzodiazepine analogs as isoform-selective human lysine deacetylase inhibitorsD. Rajasekhar Reddy, Flavio Ballante, Nancy Zhou, Garland R. Marshall · 2016 · European Journal of Medicinal Chemistry
- A Highly Potent and Selective Histone Deacetylase 6 Inhibitor Prevents DSS-Induced Colitis in MiceTing Liu, Renping Wang, Haojie Xu, Yunlong Song, Yunpeng Qi · 2017 · Biological and Pharmaceutical Bulletin
- Carboxylic acid derivatives display potential selectivity for human histone deacetylase 6: Structure-based virtual screening, molecular docking and dynamics simulation studiesAbdullahi İbrahim Uba, Kemal Yelekçi · 2018 · Computational Biology and Chemistry
- Pharmacophore-based virtual screening for identification of potential selective inhibitors of human histone deacetylase 6Abdullahi İbrahim Uba, Kemal Yelekçi · 2018 · Computational Biology and Chemistry
- Regulation of Fibroblast Apoptosis and Proliferation by Micro RNA ‐125b in Systemic SclerosisAnastasiia Kozlova, Elena Pachera, Britta Maurer, Astrid Jüngel, Jörg H. W. Distler, Gabriela Kania, Oliver Distler · 2019 · Arthritis & Rheumatology
- X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10Corey J. Herbst‐Gervasoni, David W. Christianson · 2021 · Biochemistry
- Novel N-hydroxyfurylacrylamide-based histone deacetylase (HDAC) inhibitors with branched CAP group (Part 2)Taotao Feng, Hai Wang, Hong Lin Su, Hui Lu, Li‐Qin Yu, Xiaojin Zhang, Haopeng Sun, Qidong You · 2013 · Bioorganic & Medicinal Chemistry
- Histone deacetylase 6 plays an important role in TGF-β-induced murine Treg cell differentiation by regulating cell proliferationJi Hyeon Lee, Hyeong Su Kim, Sung Woong Jang, Gap Ryol Lee · 2022 · Scientific Reports
- RETRACTED ARTICLE: Discovery of novel benzohydroxamate-based histone deacetylase 6 (HDAC6) inhibitors with the ability to potentiate anti-PD-L1 immunotherapy in melanomaXiaopeng Peng, Ziwen Yu, Goverdhan Surineni, Bulian Deng, Meizhu Zhang, Chuan Li, Zhiqiang Sun, Wanyi Pan, Yao Liu, Shenglan Liu et al. · 2023 · Journal of Enzyme Inhibition and Medicinal Chemistry · Retracted
- Anticancer RuII and RhIII Piano‐Stool Complexes that are Histone Deacetylase InhibitorsJasmine M. Cross, Tim R. Blower, Natalie Gallagher, Jason H. Gill, Kimberly L. Rockley, James W. Walton · 2016 · ChemPlusChem
- Rescue of CAMDI deletion‐induced delayed radial migration and psychiatric behaviors by HDAC6 inhibitorToshifumi Fukuda, Shun Nagashima, Takaya Abe, Hiroshi Kiyonari, Ryoko Inatome, Shigeru Yanagi · 2016 · EMBO Reports
- Combined Ligand and Fragment‐based Drug Design of Selective Histone Deacetylase – 6 InhibitorsDušan Ružić, Miloš Petković, Danica D. Agbaba, Arasu Ganesan, Katarina M. Nikolic · 2019 · Molecular Informatics
- First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement**Daniel Herp, Johannes Ridinger, Dina Robaa, Stephen A. Shinsky, Karin Schmidtkunz, Talha Z. Yesiloglu, Theresa Bayer, Raphael R. Steimbach, Corey J. Herbst‐Gervasoni, Annika Merz et al. · 2022 · ChemBioChem
- Structure-activity relationship study of thiazolyl-hydroxamate derivatives as selective histone deacetylase 6 inhibitorsGibeom Nam, Jun Min Jung, Hyun‐Ju Park, Seung Yeop Baek, Ki Seon Baek, Hui yeon Mok, Da Eun Kim, Young Hoon Jung · 2019 · Bioorganic & Medicinal Chemistry
- Design of Selective Histone Deacetylase Inhibitors: Rethinking Classical PharmacophoreJelena Melesina, Lucas Praetorius, Conrad Veranso Simoben, Dina Robaa, Wolfgang Sippl · 2018 · Future Medicinal Chemistry
- A selenium-containing selective histone deacetylase 6 inhibitor for targeted in vivo breast tumor imaging and therapyChu Chi Tang, Yang Du, Qian Ying Liang, Zhen Cheng, Jie Tian · 2019 · Journal of Materials Chemistry B
- HDAC6 Substrate Discovery Using Proteomics-Based Substrate Trapping: HDAC6 Deacetylates PRMT5 to Influence Methyltransferase ActivityInosha D. Gomes, Udana V. Ariyaratne, Mary Kay H. Pflum · 2021 · ACS Chemical Biology
- Computer- and structure-based lead design for epigenetic targetsRalf Heinke, Luca Carlino, Srinivasaraghavan Kannan, Manfred Jung, Wolfgang Sippl · 2011 · Bioorganic & Medicinal Chemistry
- Computer-aided identification of new histone deacetylase 6 selective inhibitor with anti-sepsis activityJakyung Yoo, Sojin Kim, Dohyun Son, Heewon Seo, Seung Yeop Baek, Cheol-Young Maeng, Changsik Lee, In Su Kim, Young Hoon Jung, Sun‐Mee Lee et al. · 2016 · European Journal of Medicinal Chemistry
- Synthesis of Structurally Diverse 2,3-Fused Indoles via Microwave-Assisted AgSbF6-Catalysed Intramolecular Difunctionalization of o-AlkynylanilinesYuanqiong Huang, Yan Yang, Hongjian Song, Yuxiu Liu, Qingmin Wang · 2015 · Scientific Reports
- Recent Advances in Small Molecular Modulators Targeting Histone Deacetylase 6Yufeng Xiao, Xuan Zhang · 2020 · Future Drug Discovery
- Profiling of Substrates for Zinc‐dependent Lysine Deacylase Enzymes: HDAC3 Exhibits Decrotonylase Activity In VitroAndreas S. Madsen, Christian Adam Olsen · 2012 · Angewandte Chemie
- The epigenetic landscape of rheumatoid arthritis: Pathogenesis and drug therapeutic potentialsChengcheng Huang, Yuxiang Liang, Yang Li, Wei Quan, Liang Ouyang, Jifa Zhang · 2025 · Acta Pharmaceutica Sinica B
- Design, Synthesis, and biological evaluation of HDAC6 inhibitors based on Cap modification strategyXuedong Li, Xingang Liu, Songsong Wang, Xiaoxing Shi, Ming Lü, Xinyue Hao, Yan Fu, Yang Zhang, Qingzhong Jia, Dian He · 2022 · Bioorganic Chemistry
- HDAC6 inhibitor ACY-1083 shows lung epithelial protective features in COPDJenny Horndahl, Rebecka Svärd, Pia Berntsson, Cecilia Wingren, Jingjing Li, Suado M. Abdillahi, Baishakhi Ghosh, Erin Capodanno, Justin Chan, Lena Ripa et al. · 2022 · PLoS ONE
- Targeting epigenetic regulation for cancer therapy using small molecule inhibitorsAmit Kumar, Luni Emdad, Paul B. Fisher, Swadesh Kumar Das · 2023 · Advances in cancer research
- Contilisant+Tubastatin A Hybrids: Polyfunctionalized Indole Derivatives as New HDAC Inhibitor-Based Multitarget Small Molecules with In Vitro and In Vivo Activity in Neurodegenerative DiseasesMireia Toledano‐Pinedo, Alicia Porro-Pérez, Linda Schäker‐Hübner, Fernando Romero, Min Dong, Abdelouahid Samadi, Pedro Almendros, Isabel Iriepa, Óscar M. Bautista‐Aguilera, M. Mercedes Rodríguez‐Fernández et al. · 2024 · Journal of Medicinal Chemistry
- Structure-activity relationship and mechanistic studies for a series of cinnamyl hydroxamate histone deacetylase inhibitorsMaurício T. Tavares, Larissa Costa de Almeida, Thales Kronenberger, Gláucio Monteiro Ferreira, Thainá Fujii de Divitiis, Mônica F. Z. J. Toledo, Neuza Mariko Aymoto Hassimotto, João Agostinho Machado‐Neto, Letícia Veras Costa-Lotufo, Roberto Parise‐Filho · 2021 · Bioorganic & Medicinal Chemistry
- Constructions of tetrahydro-γ-carboline skeletons via intramolecular oxidative carbon–carbon bond formation of enaminesJinglei Lv, Ji Li, Daisy Zhang‐Negrerie, Siyun Shang, Qingzhi Gao, Yunfei Du, Kang Zhao · 2013 · Organic & Biomolecular Chemistry
- tert‐Butylcarbamate‐Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer CellsSérgio Valente, Daniela Trisciuoglio, Maria Tardugno, Rosaria Benedetti, Donatella Labella, Daniela Secci, Ciro Mercurio, Roberto Boggio, Stefano Tomassi, Salvatore Di Maro et al. · 2013 · ChemMedChem
- HDAC and Ku70 axis- an effective target for apoptosis induction by a new 2-cyano-3-oxo-1,9-dien glycyrrhetinic acid analoguePing Gong, Kun Li, Ying Li, Dan Liu, Linxiang Zhao, Yongkui Jing · 2018 · Cell Death and Disease
- The interplay between G protein-coupled receptor kinase 2 (GRK2) and histone deacetylase 6 (HDAC6) at the crossroads of epithelial cell motilityVanesa Lafarga, Federico Mayor, Petronila Penela · 2012 · Cell Adhesion & Migration
- HDAC6 inhibitor-loaded brain-targeted nanocarrier-mediated neuroprotection in methamphetamine-driven Parkinson's diseaseKhang‐Yen Pham, Shristi Khanal, Ganesh Bohara, Nikesh Rimal, Sang-Hoon Song, Thoa Thi Kim Nguyen, In‐Sun Hong, Jinkyung Cho, Jong-Sun Kang, Sooyeun Lee et al. · 2024 · Redox Biology
- Calcium signals act through histone deacetylase to mediate pronephric kidney morphogenesisSarah C. Rothschild, Hunter J. Lee, Sarah Ingram, Daniel K. Mohammadi, Gregory S. Walsh, Robert M. Tombes · 2018 · Developmental Dynamics
- Therapeutic Potential of CKD-504, a Novel Selective Histone Deacetylase 6 Inhibitor, in a Zebrafish Model of Neuromuscular Junction DisordersHui Su Jeong, Hye Jin Kim, Deok‐Ho Kim, Ki Wha Chung, Byung‐Ok Choi, Ji Eun Lee · 2022 · Molecules and Cells
- Evaluation of functional groups on amino acids in cyclic tetrapeptides in histone deacetylase inhibitionMd. Shahidul Islam, Mohammed P. I. Bhuiyan, Md. Nurul Islam, Tienabe K. Nsiama, Naoto Oishi, Tamaki Kato, Norikazu Nishino, Akihiro Ito, Minoru Yoshida · 2011 · Amino Acids
- Identification of histone deacetylase inhibitors with (arylidene)aminoxy scaffold active in uveal melanoma cell linesSusanna Nencetti, Doretta Cuffaro, Elisa Nuti, Lidia Ciccone, Armando Rossello, Marina Fabbi, Flavio Ballante, Gabriella Ortore, Grazia Carbotti, Francesco Campelli et al. · 2020 · Journal of Enzyme Inhibition and Medicinal Chemistry
- The antileishmanial activity of isoforms 6- and 8-selective histone deacetylase inhibitorsQuaovi H. Sodji, Vishal Patil, Surendra Jain, James R. Kornacki, Milan Mrksich, Babu Lal Tekwani, Adegboyega K. Oyelere · 2014 · Bioorganic & Medicinal Chemistry Letters
- Inhibition of histone deacetylase 6 restores innate immune cells in the bone marrow in a lethal septic modelTing Zhao, Yongqing Li, Baoling Liu, Baihong Pan, Xin Min Cheng, Patrick E. Georgoff, Hasan Badre Alam · 2015 · The Journal of Trauma: Injury, Infection, and Critical Care
- Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitorsPradeep S. Jadhavar, Sreekanth A. Ramachandran, Eduardo Riquelme, Ashu Gupta, Kevin P. Quinn, Devleena Shivakumar, Soumya S. Ray, Dnyaneshwar Zende, Anjan K. Nayak, Sandeep K. Miglani et al. · 2016 · Bioorganic & Medicinal Chemistry Letters
- Silver–copper co-catalyzed cascade intramolecular cyclization/desulfinamide/dehydrogenation: one-pot synthesis of substituted carbazolesYuanqiong Huang, Zhonglin Guo, Hongjian Song, Yuxiu Liu, Qingmin Wang · 2018 · Chemical Communications
- Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoformChristopher Blackburn, Cynthia Barrett, Mable Brunson, Janice E. Chin, Dylan B. England, Kris Garcia, Kenneth M. Gigstad, Alexandra E. Gould, Juan A. Gutierrez, Kara M. Hoar et al. · 2014 · Bioorganic & Medicinal Chemistry Letters
- Histone deacetylase 6 inhibitors with blood-brain barrier penetration as a potential strategy for CNS-Disorders therapyXiu Quan Gu, Hao Zhang, Min-Ru Jiao, Bo Ram Han, Zixue Zhang, Jianqi Li, Qingwei Zhang · 2021 · European Journal of Medicinal Chemistry
- Design, synthesis, and anti-inflammatory activity characterization of novel brain-permeable HDAC6 inhibitorsGang Liu, Prasenjit Mondal, Na Sang, Zihua Li, Weihua Ding, Liuyue Yang, Yan Liu, Vishal C. Birar, Ashley Gomm, Rudolph E. Tanzi et al. · 2023 · European Journal of Medicinal Chemistry
- Pioneering first‐in‐class FAAH‐HDAC inhibitors as potential multitarget neuroprotective agentsAlessandro Papa, Ilaria Cursaro, Luca Pozzetti, Chiara Contri, Martina Cappello, Silvia Pasquini, Gabriele Carullo, Anna Ramunno, Sandra Gemma, Katia Varani et al. · 2023 · Archiv der Pharmazie
- Histone deacetylase 6 controls cardiac fibrosis and remodelling through the modulation of TGF ‐β1/Smad2/3 signalling in post‐infarction miceJunqiao Fang, Shangzhi Shu, Hui Dong, Xueling Yue, Jinshun Piao, Shuyan Li, Lan Hong, Xian Wu Cheng · 2024 · Journal of Cellular and Molecular Medicine
- Development of second generation epigenetic agentsPHILIP G. JONES · 2011 · MedChemComm
- Perfluorinated HDAC inhibitors as selective anticancer agentsJames W. Walton, Jasmine M. Cross, Tina Riedel, Paul J. Dyson · 2017 · Organic & Biomolecular Chemistry
- Discovery of specific HDAC6 inhibitor with anti-metastatic effects in pancreatic cancer cells through virtual screening and biological evaluationHaoxuan Song, Xueyan Niu, Jishun Quan, Yanchun Li, Lei Yuan, Jian Wang, Chao Ma, Enlong Ma · 2020 · Bioorganic Chemistry
- Molecular design, synthesis and in vitro biological evaluation of thienopyrimidine–hydroxamic acids as chimeric kinase HDAC inhibitors: a challenging approach to combat cancerMona M. Abdel-Atty, Nahla A. Farag, Rabah A.T. Serya, Khaled A. M. Abouzid, Samar Mowafy · 2021 · Journal of Enzyme Inhibition and Medicinal Chemistry
- Antitumor activity of novel POLA1-HDAC11 dual inhibitorsSabrina Dallavalle, Loana Musso, Raffaella Cincinelli, Nadine Darwiche, Silvia I. Gervasoni, Giulio Vistoli, Mario Berardino Guglielmi, Ilaria La Porta, Maddalena Pizzulo, Elisa Modica et al. · 2021 · European Journal of Medicinal Chemistry
- Atrial fibrillationBianca J.J.M. Brundel, Ai, Xun, Hills, Mellanie True, Myrthe F. Kuipers, Gregory Y.H. Lip, Natasja M. S. de Groot · 2016 · Nature Reviews Disease Primers
- Discovery of BRAF/HDAC Dual Inhibitors Suppressing Proliferation of Human Colorectal Cancer CellsYingjun Li, Yongjun Huang, Huimin Cheng, Fang Lian Xu, Ruxi Qi, Botao Dai, Yujian Yang, Zhengchao Tu, Lijie Peng, Zhang Zhang · 2022 · Frontiers in Chemistry
- Discovery of 1-Benzhydryl-Piperazine-Based HDAC Inhibitors with Anti-Breast Cancer Activity: Synthesis, Molecular Modeling, In Vitro and In Vivo Biological EvaluationDušan Ružić, Milos Petkovic, Nemanja Djoković, Juan Francisco Santibanez, Bernhard Ellinger, Milan Beljkaš, Sheraz Gul, Ana Djuric, A. Ganesan, Aleksandar Pavić et al. · 2022 · Pharmaceutics
- Class II histone deacetylases require P/Q-type Ca2+ channels and CaMKII to maintain gamma oscillations in the pedunculopontine nucleusFrancisco J. Urbano, Verónica Bisagno, Susan Mahaffey, Sang-Hun Lee, Edgar García‐Rill · 2018 · Scientific Reports
- Genetic deletion or pharmacologic inhibition of histone deacetylase 6 protects the heart against ischaemia/reperfusion injury by limiting tumour necrosis factor alpha–induced mitochondrial injury in experimental diabetesShelley L. Baumgardt, Juan Fang, Xuebin Fu, Yanan Liu, Zhengyuan Xia, Ming Zhao, Ling Chen, Rachana Mishra, Muthukumar Gunasekaran, Progyaparamita Saha et al. · 2024 · Cardiovascular Research
- Development of Hydrazide-Based HDAC6 Selective Inhibitors for Treating NLRP3 Inflammasome-Related DiseasesKairui Yue, Simin Sun, Zequn Yin, Enqiang Liu, Geng Jia, Yuqi Jiang, Yajun Duan, Yuxin Chen, Xiaoyang Li · 2025 · Journal of Medicinal Chemistry
- Targeting Neuroblastoma Cell Surface Proteins: Recommendations for Homology Modeling of hNET, ALK, and TrkBYazan Haddad, Zbyněk Heger, Vojtěch Adam · 2017 · Frontiers in Molecular Neuroscience
- Structure-based design generated novel hydroxamic acid based preferential HDAC6 lead inhibitor with on-target cytotoxic activity against primary choroid plexus carcinomaShaymaa Emam Kassab, Samar Mowafy, Aya M. Alserw, Joustin A. Seliem, Shahenda El‐Naggar, Nesreen Nabil Omar, Mohamed Medhat Awad · 2019 · Journal of Enzyme Inhibition and Medicinal Chemistry
- Exploring structural requirements of isoform selective histone deacetylase inhibitors: a comparative in silico studyKriti Kashyap, Rita Kakkar · 2020 · Journal of Biomolecular Structure and Dynamics
- Inhibition of cell migration and induction of apoptosis by a novel class II histone deacetylase inhibitor, MCC2344Mona Dawood, Edmond Fleischer, Anette Klinger, Gerhard Bringmann, Letian Shan, Thomas Efferth · 2020 · Pharmacological Research
- HDAC6 contributes to human resistance against Mycobacterium tuberculosis infection via mediating innate immune responsesFuzhen Zhang, Shanshan Yu, Qiyao Chai, Jing Wang, Tuoya Wu, Rongmei Liu, Yi Liu, Cui Hua Liu, Yu Pang · 2021 · The FASEB Journal
- Histone acetylation inhibitors promote axon growth in adult dorsal root ganglia neuronsShen Lin, Kutaiba Nazif, Alexander Smith, Peter W. Baas, George M. Smith · 2015 · Journal of Neuroscience Research
- Molecular docking-based virtual drug screening revealing an oxofluorenyl benzamide and a bromonaphthalene sulfonamido hydroxybenzoic acid as HDAC6 inhibitors with cytotoxicity against leukemia cellsMona Dawood, Mohamed Elbadawi, Madeleine Böckers, Gerhard Bringmann, Thomas Efferth · 2020 · Biomedicine & Pharmacotherapy
- HDAC InhibitorsHeidi Olzscha, Mina Bekheet, Semira Sheikh, Nicholas Barrie La Thangue · 2016 · Methods in molecular biology
- Aromatic Ring Fluorination Patterns Modulate Inhibitory Potency of Fluorophenylhydroxamates Complexed with Histone Deacetylase 6Paris R. Watson, Ping Bai, Changning Wang, Abigail D. Cragin, Jacob M. Hooker, David W. Christianson · 2022 · Biochemistry
- Green oxidative rearrangement of indoles using halide catalyst and hydrogen peroxideJian Wang, Yini Chen, Wanting Du, Ningyao Chen, Kang Fu, Qijun He, Liming Shao · 2022 · Tetrahedron
- Multimechanism biological profiling of tetrahydro-β-carboline analogues as selective HDAC6 inhibitors for the treatment of Alzheimer's diseaseTing Liang, Shiru Liu, Baiyun Dang, Xiaofa Luan, Yifan Guo, Raphael R. Steimbach, Jiadong Hu, Long Lu, Peiyu Yue, Ruotian Wang et al. · 2024 · European Journal of Medicinal Chemistry
- Rationale for HDAC Inhibitor Therapy in Autoimmunity and TransplantationWayne W. Hancock · 2011 · Handbook of experimental pharmacology
- Exploration of the labeling of [11C]tubastatin A at the hydroxamic acid site with [11C]carbon monoxideShuiyu Lu, Yi Zhang, Jay H. Kalin, Lisheng Cai, Alan P. Kozikowski, Victor William Pike · 2015 · Journal of Labelled Compounds and Radiopharmaceuticals
- Borinostats: solid-phase synthesis of carborane-capped histone deacetylase inhibitors with a tailor-made selectivity profileChristoph Selg, Andrea Schöler, Julian Schliehe‐Diecks, Maria Hanl, Laura Sinatra, Arndt Borkhardt, Menyhárt B. Sárosi, Sanil Bhatia, Evamarie Hey‐Hawkins, Finn Kristian Hansen · 2021 · Chemical Science
- Involvement of transcription factor XBP1s in the resistance of HDAC6 inhibitor Tubastatin A to superoxidation via acetylation-mediated proteasomal degradationYue Zhang, Chang‐Mei Liu, Xian-cao Cao, Yi Zang, Yubo Zhou, Jia Xuan Li · 2014 · Biochemical and Biophysical Research Communications
- Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamatesVincent Zwick, Alessandra Nurisso, Claudia Avello Simões‐Pires, Samuel Bouchet, Nadine Martinet, Attila Lehotzky, Judit Ovádi, Muriel Cuendet, Christophe Blanquart, Philippe Bertrand · 2015 · Bioorganic & Medicinal Chemistry Letters
- Overview of Computer-Aided Drug Design for Epigenetic TargetsRodrigo Aguayo‐Ortiz, Eli Fernández‐de Gortari · 2016 · Elsevier eBooks
- Targeting histone deacetylases for heart diseasesGang Y Jin, Kaiyue Wang, Yaohui Zhao, Shuo Yuan, Zhangxu He, Jingyu Zhang · 2023 · Bioorganic Chemistry
- Structure–Activity Relationship of Propargylamine‐Based HDAC InhibitorsMatthias Wünsch, Johanna Senger, Philipp Schultheisz, Sabrina Schwarzbich, Karin Schmidtkunz, Carmela Michalek, Michaela Klaß, Stefanie Goskowitz, Philipp Borchert, Lucas Praetorius et al. · 2017 · ChemMedChem
- Tubastatin A, a deacetylase inhibitor, as a tool to study the division, cell cycle and microtubule cytoskeleton of trypanosomatidsJean de Oliveira Santos, Aline Araújo Zuma, Wanderley de Souza, María Cristina M. Motta · 2021 · European Journal of Protistology
- Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2Aditya Sudheer Vaidya, Bhargava Karumudi, Emma L. Mendonca, Antonett Madriaga, Hazem Abdelkarim, Richard Bruce van Breemen, Pavel A. Petukhov · 2012 · Bioorganic & Medicinal Chemistry Letters
- Diagnosis and Therapy of Atrial Fibrillation: The Past, The Present and The Future.Denise M.S. van Marion, Eva A.H. Lanters, Marit Wiersma, Maurits A. Allessie, Bianca J.J.M. Brundel, Natasja M. S. de Groot · 2015 · PubMed Central
- Image-based drug screen identifies HDAC inhibitors as novel Golgi disruptors synergizing with JQ1Mathieu Gendarme, Jan Baumann, Tatiana I. Ignashkova, Ralph K. Lindemann, Jan H. Reiling · 2017 · Molecular Biology of the Cell
- Evaluation of [11C]KB631 as a PET tracer for in vivo visualisation of HDAC6 in B16.F10 melanomaKoen Vermeulen, Muneer Ahamed, Kaat Luyten, Guy M Bormans · 2019 · Nuclear Medicine and Biology
- Epigenetic Drug Discovery for Alzheimer’s DiseaseRamón Cacabelos, Óscar Teijido · 2017 · Elsevier eBooks