Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

Butler, Kyle V., Kalin, Jay, Brochier, Camille, Vistoli, Guilio, Langley, Brett, Kozikowski, Alan P.·2010·Journal of the American Chemical Society
DOI 10.1021/ja102758v

Cited by (902)

Items 801–900 of 902

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  29. BindingDB Entry 50022156: Contilisant+Tubastatin A Hybrids: Polyfunctionalized Indole Derivatives as New HDAC Inhibitor-Based Multitarget Small Molecules with In Vitro and In Vivo Activity in Neurodegenerative Diseases.
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  30. BindingDB Entry 50047055: Design, Synthesis, and Pharmacological Evaluation of Novel N-Acylhydrazone Derivatives as Potent Histone Deacetylase 6/8 Dual Inhibitors.
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  54. BindingDB Entry 50023583: Development of Hydrazide-Based HDAC6 Selective Inhibitors for Treating NLRP3 Inflammasome-Related Diseases.
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  59. BindingDB Entry 50010615: Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor.
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  60. BindingDB Entry 50021935: Re-exploration of tetrahydro-β-carboline scaffold: Discovery of selective histone deacetylase 6 inhibitors with neurite outgrowth-promoting and neuroprotective activities.
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  61. BindingDB Entry 50002898: The structural requirements of histone deacetylase inhibitors: C4-modified SAHA analogs display dual HDAC6/HDAC8 selectivity.
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  63. BindingDB Entry 50000061: Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines.
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  64. BindingDB Entry 50045731: Design and synthesis of orally bioavailable aminopyrrolidinone histone deacetylase 6 inhibitors.
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  92. BindingDB Entry 50047915: Synthesis of a selective HDAC6 inhibitor active in neuroblasts.
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  93. BindingDB Entry 50046307: Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).
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  94. BindingDB Entry 50047970: Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors.
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  95. BindingDB Entry 50020538: Development and Pharmacochemical Characterization Discover a Novel Brain-Permeable HDAC11-Selective Inhibitor with Therapeutic Potential by Regulating Neuroinflammation in Mice.
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  96. BindingDB Entry 50000517: Synthesis and applications of benzohydroxamic acid-based histone deacetylase inhibitors.
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  97. BindingDB Entry 50013572: Design, synthesis and biological evaluation of brain penetrant benzazepine-based histone deacetylase 6 inhibitors for alleviating stroke-induced brain infarction.
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  98. BindingDB Entry 50013337: Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1.
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  99. Targeting the catalytic and ZnF-UBP domains of HDAC6 differentially controls NLRP3 inflammasome priming and assembly in paclitaxel-induced peripheral neuropathy
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