Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

Butler, Kyle V., Kalin, Jay, Brochier, Camille, Vistoli, Guilio, Langley, Brett, Kozikowski, Alan P.·2010·Journal of the American Chemical Society

DOI 10.1021/ja102758v

Cited by (902)

Items 501–600 of 902

HDAC inhibitor ameliorates behavioral deficits in Mecp2308/y mouse model of Rett syndrome
Nicolas Lebrun, Chloé Delépine, Mohammed Selloum, Hamid Méziane, Juliette Nectoux, Yann Hérault, Thierry Bienvenu · 2021 · Brain Research
Histone deacetylases and their inhibitors in kidney diseases
Yue Zheng, Tie‐Ning Zhang, Peng-Hui Hao, Ni Yang, Yue Du · 2025 · Molecular Therapy
Comprehensive Analysis of Mouse Cancer/Testis Antigen Functions in Cancer Cells and Roles of TEKT5 in Cancer Cells and Testicular Germ Cells
Nana Aoki, Yasuhisa Matsui · 2019 · Molecular and Cellular Biology
HSP90 N‐terminal inhibitors target oncoprotein MORC2 for autophagic degradation and suppress MORC2‐driven breast cancer progression
Fan Yang, Rui Sun, Zeng Hou, Fang-Lin Zhang, Yi Xiao, Yun‐Song Yang, Shao‐Ying Yang, Yifan Xie, Yingying Liu, Cheng Luo et al. · 2022 · Clinical and Translational Medicine
Arylsulfonylation-Triggered Cyclization of 3-Alkenyl Indoles Enabling Synthesis of Tetrahydro-γ-carboline
Aiyao Liu, Jingrui He, Yingjie Yu, Chengting Wang, Haibo Mei, Jianlin Han · 2022 · The Journal of Organic Chemistry
Selective HDAC6 inhibition protects against blood–brain barrier dysfunction after intracerebral hemorrhage
Cuiying Peng, Yilin Wang, Zhiping Hu, Chunli Chen · 2023 · CNS Neuroscience & Therapeutics
Synthesis of a selective HDAC6 inhibitor active in neuroblasts
Vincent Zwick, Claudia Avello Simões‐Pires, Alessandra Nurisso, Charlotte Petit, Carolina dos Santos Passos, Giuseppe Marco Randazzo, Nadine Martinet, Philippe Bertrand, Muriel Cuendet · 2016 · Bioorganic & Medicinal Chemistry Letters
Structural insights of SmKDAC8 inhibitors: Targeting Schistosoma epigenetics through a combined structure-based 3D QSAR, in vitro and synthesis strategy
Flavio Ballante, D. Rajasekhar Reddy, Nancy Zhou, Garland R. Marshall · 2017 · Bioorganic & Medicinal Chemistry
Developmental neurotoxicity in the context of multiple sevoflurane exposures: Potential role of histone deacetylase 6
Guohui Li, Jianer Du, Lai Wang, Xueyin Shi · 2019 · Neurotoxicology and Teratology
Synthetic Conjugates of Ursodeoxycholic Acid Inhibit Cystogenesis in Experimental Models of Polycystic Liver Disease
Francisco Javier Caballero-Camino, Iván Rivilla, Elisa Herráez, Óscar Briz, Álvaro Santos‐Laso, Laura Izquierdo‐Sánchez, Pui Yuen Lee, Pedro Miguel Rodrigues, Patricia Muñoz-Garrido, Sujeong Jin et al. · 2020 · Hepatology
HDAC6 deficiency or inhibition blocks FGFR3 accumulation and improves bone growth in a model of achondroplasia
Sara Ota, Zi-Qiang Zhou, Megan P. Romero, Guang Yang, Peter J. Hurlin · 2016 · Human Molecular Genetics
Acetylation of α-tubulin restores endothelial cell injury and blood–brain barrier disruption after intracerebral hemorrhage in mice
Xuejiao Lei, Eryi Sun, Xufang Ru, Yulian Quan, Xuezhu Chen, Qian Zhang, Yong Lü, Qianying Huang, Yujie Chen, Wenyan Li et al. · 2025 · Experimental & Molecular Medicine
Scalable Synthesis of Silacyclohexanones and Ready Access to Silicon Building Blocks
Eagala Ramesh, Laxman D. Nandawadekar, Ramana Sreenivasa Rao, D. Srinivasa Reddy · 2023 · Organic Letters
Epigenetic meets metabolism: novel vulnerabilities to fight cancer
Domenica Scumaci, Qingfei Zheng · 2023 · Cell Communication and Signaling
Exploring new histone deacetylase 6 inhibitors and their effects on reversing the α-tubulin deacetylation and cell morphology changes caused by methamphetamine
Sunil Gupta, Khan Hashim Ali, Sooyeun Lee, Young Ho Seo · 2023 · Archives of Pharmacal Research
The Role of HDAC6 in Glioblastoma Multiforme: A New Avenue to Therapeutic Interventions?
Francesco Spallotta, Barbara Illi · 2024 · Biomedicines
Selective inhibition of histone deacetylase 6 alters the composition of circulating blood cells in a lethal septic model
Ting Zhao, Yongqing Li, Baoling Liu, Ihab F. Halaweish, Ralph Mazitschek, Hasan Badre Alam · 2014 · Journal of Surgical Research
Tubastatin A inhibits HDAC and Sirtuin activity rather than being a HDAC6-specific inhibitor in mouse oocytes
Yun‐Jung Choi, Min-Hee Kang, Kwonho Hong, Jin‐Hoi Kim · 2019 · Aging
Anticancer Ruthenium Complexes with HDAC Isoform Selectivity
Jasmine M. Cross, Tim R. Blower, Alexander D. H. Kingdon, Róbert Pál, David M. Picton, James W. Walton · 2020 · Molecules
2-Benzazolyl-4-Piperazin-1-Ylsulfonylbenzenecarbohydroxamic Acids as Novel Selective Histone Deacetylase-6 Inhibitors with Antiproliferative Activity
Lei Wang, Marina Kofler, Gerald Brosch, Jelena Melesina, Wolfgang Sippl, Elisabeth D. Martínez, Johnny Easmon · 2015 · PLoS ONE
Insecticidal activities of histone deacetylase inhibitors against a dipteran parasite of sheep, Lucilia cuprina
Neil H. Bagnall, Barney M. Hines, Andrew J. Lucke, Praveer K. Gupta, Robert C. Reid, David P. Fairlie, Andrew C. Kotze · 2017 · International Journal for Parasitology Drugs and Drug Resistance
Discovery of novel inhibitors of histone deacetylase 6: Structure-based virtual screening, molecular dynamics simulation, enzyme inhibition and cell viability assays
Abdullahi İbrahim Uba, Mariya Hryb, Mursalin Singh, Candice Bui-Linh, Annie Tran, Jiancarlo Atienza, Sarah Misbah, Xiaoyang Mou, Chun Fu Wu · 2024 · Life Sciences
SAHA is neuroprotective in in vitro and in situ models of retinitis pigmentosa.
Nathan R. Perron, Cécile Nasarre, Mausumi Bandyopadhyay, Craig Cano Beeson, Bäerbel Rohrer · 2021 · PubMed Central
Discovery of Benzylpiperazine Derivatives as CNS-Penetrant and Selective Histone Deacetylase 6 Inhibitors
Kosuke Hashimoto, Soichiro Ide, Mayumi Arata, Akiko Nakata, Akihiro Ito, Takashi K. Ito, Norio Kudo, Bangzhong Lin, Kazuto Nunomura, Keiko Tsuganezawa et al. · 2022 · ACS Medicinal Chemistry Letters
Novel Histone Deacetylase 6 Inhibitor Confers Anti-inflammatory Effects and Enhances Gut Barrier Function
Jae-Young Lee, Hyun Jun Woo, Ji Hyung Kim, I Seul Park, Mijeong Son, Keun Ho Ryu, Jieun Shin, Seung Won Kim, Jae Hee Cheon · 2022 · Gut and Liver
Histone deacetylase 6 inhibition promotes microtubule acetylation and facilitates autophagosome–lysosome fusion in dystrophin‐deficient mdx mice
Akanksha Agrawal, Erin L. Clayton, Courtney L. Cavazos, Benjamin A. Clayton, George Gerald Rodney · 2024 · Acta Physiologica
Identification of HDAC6 selective inhibitors: pharmacophore based virtual screening, molecular docking and molecular dynamics simulation
Guoyi Yan, Dongxiao Li, Xin-Xin Zhong, Ge Liu, Xueqin Wang, Yuanxiang Lu, Fangyuan Qin, Yuqi Guo, Shaofeng Duan, Deyu Li · 2020 · Journal of Biomolecular Structure and Dynamics
Cell-based multi-substrate assay coupled to UHPLC-ESI-MS/MS for a quick identification of class-specific HDAC inhibitors
Vincent Zwick, Claudia Avello Simões‐Pires, Muriel Cuendet · 2016 · Journal of Enzyme Inhibition and Medicinal Chemistry
Metal-Catalyzed Cascade Reactions between Alkynoic Acids and Dinucleophiles: A Review
María Teresa Herrero, Jokin Díaz de Sarralde, Nerea Conde, Aitor Herrán, Garazi Urgoitia, Raúl SanMartı́n · 2023 · Catalysts
HDAC6 deacetylates IDH1 to promote the homeostasis of hematopoietic stem and progenitor cells
Jia Yang, Yang Liu, Hanxiao Yin, Songbo Xie, Linlin Zhang, Xifeng Dong, Hua Ni, Weiwen Bu, Hongbo Ma, Peng Liu et al. · 2023 · EMBO Reports
Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137)
Claudia Avello Simões‐Pires, Philippe Bertrand, Muriel Cuendet · 2017 · Expert Opinion on Therapeutic Patents
Modeling zinc‐oxygen coordination in histone deacetylase: A comparison of semiempirical methods performance
Pedro de Sena Murteira Pinheiro, Daniel Alencar Rodrigues, Carlos Maurício R. Sant’Anna, Carlos Alberto Manssour Fraga · 2018 · International Journal of Quantum Chemistry
Histone deacetylase inhibitors prevent H2O2 from inducing stress granule formation
Si-Yuan Feng, Jennifer N. Daw, Qin M. Chen · 2020 · Current Research in Toxicology
Oxa Analogues of Nexturastat A Demonstrate Improved HDAC6 Selectivity and Superior Antileukaemia Activity
Marc Pflieger, Melf Sönnichsen, Nadine Horstick‐Muche, Jing Chun Yang, Julian Schliehe‐Diecks, Andrea Schöler, Arndt Borkhardt, Alexandra Hamacher, Matthias Ulrich Kassack, Finn K. Hansen et al. · 2021 · ChemMedChem
Discovery of novel pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione (PBD) derivatives as selective HDAC6 inhibitors for the efficient treatment of idiopathic pulmonary fibrosis (IPF) in vitro and in vivo
Yanchun Li, Huali Yang, Xiangling Zhao, Xianchen Zhao, Jishun Quan, Lei Wang, Enlong Ma, Chao Ma · 2024 · European Journal of Medicinal Chemistry
Discovery of a Novel Selective PAK1/HDAC6/HDAC10 Inhibitor ZMF-25 that Induces Mitochondrial Metabolic Breakdown and Autophagy-Related Cell Death in Triple-Negative Breast Cancer
Jin Zhang, Xiaoling Cheng, Gang Chen, Xiya Chen, Xi Zhao, Weiji Chen, Wei Ting Du, Zhendan He, Xiaojun Yao, Bo Han et al. · 2025 · Research
Development of a tetrahydroindazolone-based HDAC6 inhibitor with in-vivo anti-arthritic activity
Hyun-Mo Yang, Changsik Lee, Jaeki Min, Nina Ha, Daekwon Bae, Gibeom Nam, Hyun‐Ju Park · 2024 · Bioorganic & Medicinal Chemistry
Suppression of FGFR3- and MYC-dependent oncogenesis by tubacin: association with HDAC6-dependent and independent activities
Sara Ota, Zi-Qiang Zhou, Peter J. Hurlin · 2017 · Oncotarget
Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition
Yves Depetter, Silke Geurs, Flore Vanden Bussche, Rob De Vreese, Jorick Franceus, Tom Desmet, Olivier De Wever, Matthias D’hooghe · 2018 · MedChemComm
A new synthesis of 6-N-hydroxy-4-(2-methyl-l,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-ylmethyl)benzamide, tubastatin a, a highly selective inhibitor of histone deacetylase
Maxim V. Kozlov, Alla A. Kleymenova, Konstantin A. Konduktorov, Sergey N. Kochetkov · 2013 · Russian Journal of Bioorganic Chemistry
Electrostatic Control of Spin Exchange Between Mobile Spin-Correlated Radical Pairs Created in Micellar Solutions
Paula Caregnato, Lauren E. Jarocha, Hali S. Esinhart, Natalia V. Lebedeva, Valery F. Tarasov, Malcolm D. E. Forbes · 2011 · Langmuir
Therapeutic potential of dual HDAC6/SIRT2 inhibition in Alzheimer's disease
Xingyu Wang, Cunjiang Li, Lei Chen, Bin He, Yan Li · 2025 · European Journal of Medicinal Chemistry
Photo-driven bifunctional iron-catalyzed one-pot assembling of indoles from arylamines and alkanes/carboxylic acids
Lifang Wang, Shuyang Liu, Hui Zi, Ran Xu, Fangyi Qu, Wenlong He, Ziyu Gan, Jian Gao, Yunhe Jin · 2026 · Nature Communications
Conversion of Polyesters to Versatile Synthetic Subunits Enabled by Manganese-Catalyzed Transfer Semi-Hydrogenolysis with Ethanol
Min-Jie Zhou, Yanwei Gu, Yuehua Chen, Wenge Bian, Yue Hu, Yan Yu, Yinjun Xie · 2026 · Journal of the American Chemical Society
Effect of Tubastatin A on the Functional Recovery of Cauda Equina Injury in Rats
Zhiyi Fu, Qing‐Jie Kong, Yujie Wu, Xiaopeng Hu, Jiangang Shi · 2018 · World Neurosurgery
Rutin increases alpha‐tubulin acetylation via histone deacetylase 6 inhibition
Özge Çetin, Suat Sarı, Hayat Erdem‐Yurter, Gamze Bora · 2022 · Drug Development Research
Dihydropyrazole-Carbohydrazide Derivatives with Dual Activity as Antioxidant and Anti-Proliferative Drugs on Breast Cancer Targeting the HDAC6
Irving Balbuena-Rebolledo, Astrid M. Rivera-Antonio, Yudibeth Sixto‐López, José Correa‐Basurto, Martha Cecilia Rosales‐Hernández, Jessica Elena Mendieta‐Wejebe, Francisco J. Martı́nez-Martı́nez, Ivonne María Olivares-Corichi, José Rubén García-Sánchez, Juan Alberto Guevara‐Salazar et al. · 2022 · Pharmaceuticals
Modified Suberoylanilide Hydroxamic Acid Reduced Drug-Associated Immune Cell Death and Organ Damage under Lipopolysaccharide Inflammatory Challenge
Nhu Truong, Christopher C. Goodis, Andrea L. Cottingham, Jacob R. Shaw, Steven Fletcher, Ryan M. Pearson · 2022 · ACS Pharmacology & Translational Science
Synthesis and biological evaluation of novel N-benzyltriazolyl-hydroxamate derivatives as selective histone deacetylase 6 inhibitors
Sun Ju Kong, Gibeom Nam, Pulla Reddy Boggu, Gi Min Park, Ji-Eun Kang, Hyun‐Ju Park, Young Hoon Jung · 2023 · Bioorganic & Medicinal Chemistry
Selective HDAC6 inhibitor TubA offers neuroprotection after intracerebral hemorrhage via inhibiting neuronal apoptosis
Cuiying Peng, Xiyu Gong, Zhiping Hu, Chunli Chen, Zheng Jiang · 2023 · PeerJ
HDAC1-3 inhibition increases SARS-CoV-2 replication and productive infection in lung mesothelial and epithelial cells
Flavia Trionfetti, Tonino Alonzi, Giulio Bontempi, Michela Terri, Cecilia Battistelli, Claudia Montaldo, Federica Repele, Dante Rotili, Sérgio Valente, Clemens Zwergel et al. · 2023 · Frontiers in Cellular and Infection Microbiology
The miR‐669a‐5p/G3BP/HDAC6/AKAP12 Axis Regulates Primary Cilia Length
Weina Wang, Xuyao Dai, Yue Li, Mo Li, Zongqi Chi, Xiaoyu Hu, Zhenshan Wang · 2023 · Advanced Science
Novel HDAC6 selective inhibitors with 4-aminopiperidine-1- carboxamide as the core structure enhanced growth inhibitory activity of bortezomib in MCF-7 cells
Chenru Zhao, Jianjun Gao, Li Zhang, Li Su, Yepeng Luan · 2019 · BioScience Trends
Design, Synthesis, Bioactivity Evaluation, Crystal Structures, and In Silico Studies of New α-Amino Amide Derivatives as Potential Histone Deacetylase 6 Inhibitors
Yangrong Xu, H. Tang, YiJie Xu, Jialin Guo, Xu Zhao, Qingguo Meng, Junhai Xiao · 2022 · Molecules
PSME4 Degrades Acetylated YAP1 in the Nucleus of Mesenchymal Stem Cells
Yong Sook Kim, Mi‐Ra Kim, Dong Im Cho, Soo yeon Lim, Ju Hee Jun, Mi Ra Kim, Bo Gyeong Kang, Gwang Hyeon Eom, Gaeun Kang, Somy Yoon et al. · 2022 · Pharmaceutics
The Impact of Fluorination on the Design of Histone Deacetylase Inhibitors
Duong Tien Anh, Nguyen‐Hai Nam, Brigitte Kircher, Daniel Baecker · 2023 · Molecules
Design, Synthesis, Molecular Docking Study and Biological Evaluation of Novel γ-Carboline Derivatives of Latrepirdine (Dimebon) as Potent Anticancer Agents
Ramakrishna Voggu, Arundhati Karmakar, Venkat Swamy Puli, V. Surendra Babu Damerla, M. Padma, Pitchamuthu Amaladass, Sridhar Chidara, Kalyan Kumar Pasunooti, Sarika Gupta · 2023 · Molecules
Re-exploration of tetrahydro-β-carboline scaffold: Discovery of selective histone deacetylase 6 inhibitors with neurite outgrowth-promoting and neuroprotective activities
Wen Wen, Jiadong Hu, Chenxi Wang, Rui Yang, Yabo Zhang, Baibei Huang, Tingting Qiao, Jiayun Wang, Xin Chen · 2024 · Bioorganic & Medicinal Chemistry Letters
4-(1-Ethyl-4-anisyl-imidazol-5-yl)-N-hydroxycinnamide – A new pleiotropic HDAC inhibitor targeting cancer cell signalling and cytoskeletal organisation
Katharina Mahal, Philip Kahlen, Bernhard Biersack, Rainer Schobert · 2015 · Experimental Cell Research
Histone Deacetylase 6 Associates With Ribosomes and Regulates De Novo Protein Translation During Arsenite Stress
Kyle V. Kappeler, Jack Yin Zhang, Thai Nho Dinh, Joshua G. Strom, Qin M. Chen · 2012 · Toxicological Sciences
Challenging triple negative breast cancer through HDAC6 selective inhibition: Novel cap-group identification, structure-activity relationships, computational and biological studies
Simona Barone, Ivana Bello, Anna Guadagni, Carmen Cerchia, Gessica Filocamo, Emilia Cassese, Antonella Ilenia Alfano, Camilla Esposito, Álvaro Javier Feliz Morel, Mirko Brunetti et al. · 2025 · European Journal of Medicinal Chemistry
Discovery of selective HDAC6 inhibitors driven by artificial intelligence and molecular dynamics simulation approaches
Xingang Liu, Hao Yang, Xinyu Liu, Minjie Mou, Jie Liu, Wenying Yan, Tianle Niu, Ziyang Zhang, He Shi, Xiangdong Su et al. · 2025 · Journal of Pharmaceutical Analysis
Modulating the Secretome of Fat to Treat Heart Failure
Lorien G. Salyer, Yajing Wang, Xinliang Ma, Anna Foryst‐Ludwig, Ulrich Kintscher, Saravanakkumar Chennappan, Maria Irene Kontaridis, Timothy A. McKinsey · 2025 · Circulation Research
Design, synthesis, and biological evaluation of indazole-based histone deacetylase 6 inhibitors
Khan Hashim Ali, Sunil Gupta, Yong Jin Oh, M. Mahmun Hossain, Ji Hyun Kim, Sun You Park, Young Ho Seo · 2025 · European Journal of Medicinal Chemistry
Design and synthesis of novel histone deacetylase 6 inhibitors with benzyl-triazole as the core skeleton
Zishuo Mou, Jianjun Gao, Miao He, Li Zhang, Li Su, Baolei Wang, Yepeng Luan · 2019 · BioScience Trends
An ELISA method to assess HDAC inhibitor-induced alterations to P. falciparum histone lysine acetylation
Eva Hesping, Tina S. Skinner‐Adams, Gillian M. Fisher, Thomas Kurz, Katherine T. Andrews · 2020 · International Journal for Parasitology Drugs and Drug Resistance
Synthesis and biological evaluation of 2-quinolineacrylamides
Shih‐Wei Wang, Mei-Hsiang Lin, Fu-Chun Hsu, Mei-Chuan Chen, Jing‐Ping Liou, Yi-Ting Liu, Shiou-Sheng Chen, Hsueh‐Yun Lee · 2019 · Bioorganic & Medicinal Chemistry
A Multitargeted Approach: Organorhodium Anticancer Agent Based on Vorinostat as a Potent Histone Deacetylase Inhibitor
Muhammad Hanif, Jahan Zaib Arshad, Jonathan W. Astin, Zohaib Rana, Ayesha Zafar, Sanam Movassaghi, Euphemia Yee Leung, Kamal D. Patel, Tilo Söhnel, Jóhannes Reynisson et al. · 2020 · Angewandte Chemie
Investigation of non-hydroxamate scaffolds against HDAC6 inhibition: A pharmacophore modeling, molecular docking, and molecular dynamics simulation approach
Amir Zeb, Chanin Park, Minky Son, Shailima DV Rampogu, Syed Ibrar Alam, Seok Ju Park, Keun Woo Lee · 2018 · Journal of Bioinformatics and Computational Biology
Inhibition of histone deacetylase 6 as a therapeutic strategy for acute lymphocytic leukemia
Elizabeth A. Eklund, Leonidas C. Platanias · 2011 · Leukemia & lymphoma/Leukemia and lymphoma
Cytotoxic and Antiproliferative Activity of LASSBio-2208 and the Attempts to Determine Its Drug Metabolism and Pharmacokinetics In Vitro Profile
Raysa Magali Pillpe-Meza, Wesley Leandro Gouveia, Gisele Barbosa, Carlos Alberto Manssour Fraga, Eliezer J. Barreiro, Lı́dia Moreira Lima · 2024 · Pharmaceuticals
Impact of HDAC6-mediated progesterone receptor expression on the response of breast cancer cells to hormonal therapy
Wafaa S.H. Ramadan, Rahma K. Alseksek, Soraya Mouffak, Iman Mamdouh Talaat, Maha Mohamed Saber-Ayad, Varsha Menon, Burcu Yener İlçe, Raafat El‐Awady · 2024 · European Journal of Pharmacology
Therapeutic indications for HDAC6 inhibitors in the peripheral and central nervous disorders
Jonathan M. van Eyll, Robert Ciarán Prior, Sylvain Célanire, Ludo Van Den Bosch, Frederik J. R. Rombouts · 2024 · Expert Opinion on Therapeutic Targets
Design, synthesis, biological and in silico evaluation of 3‑carboxy‑coumarin sulfonamides as potential antiproliferative agents targeting HDAC6
José Luis Madrigal-Angulo, Gustavo A. Hernández‐Fuentes, Hortensia Parra‐Delgado, Marycruz Olvera Valdez, Itzia Irene Padilla Martínez, Ariana Cabrera‐Licona, Alexandra Espinosa‐Gil, Iván Delgado‐Enciso, Francisco Martínez‑Martínez · 2024 · Biomedical Reports
Lysine deacetylase inhibitors have low selectivity in cells and exhibit predominantly off‐target effects
Kiara E. Bornes, Marcus A. Moody, Thomas M. Huckaba, Megan C. Benz, Emily C. McConnell, Maryam K. Foroozesh, Van Barnes, Bridgette M. Collins‐Burow, Matthew E. Burow, Terry J. Watt et al. · 2024 · FEBS Open Bio
HDAC6 inhibition upregulates endothelial SOD3 expression via Sp1 acetylation and attenuates angiotensin II ‐induced hypertension
Zhexi Chi, Van Quan Do, Rukhsana Kausar, Hyun Kyung Kim, Nga Thi Thanh Nguyen, Truc Phan Hoang Le, Jungwoo Lee, In‐Jeoung Baek, Sang-wook Lee, Jae Hyung Kim et al. · 2025 · FEBS Journal
CITK modulates BRCA1 recruitment at DNA double strand breaks sites through HDAC6
Giorgia Iegiani, Gianmarco Pallavicini, Alex Pezzotta, Alessia Brix, Alessia Ferraro, Marta Gai, Enrica Boda, Stephanie L. Bielas, Anna Pistocchi, Ferdinando Di Cunto · 2025 · Cell Death and Disease
Isoform-Selective HDAC Inhibition in Autoimmune DiseaseNicole L Regna1* and Christopher M Reilly2
Christopher M. Reilly · 2014 · Journal of Clinical & Cellular Immunology
Radiosynthesis and preliminary evaluation of an 18F‐labeled tubastatin A analog for PET imaging of histone deacetylase 6
Tetsuro Tago, Jun Toyohara, Kenji Ishii · 2019 · Journal of Labelled Compounds and Radiopharmaceuticals
HDAC6 inhibition alleviates acute pulmonary embolism: a possible future therapeutic option
Tao Zhou, Di Jia, Jiahui Han, Ce Xu, Xiaohong You, Xin Ge · 2023 · Folia Histochemica et Cytobiologica
Discovery of Potent Selective HDAC6 Inhibitors with 5-Phenyl-1H-indole Fragment: Virtual Screening, Rational Design, and Biological Evaluation
Xuedong Li, Chengzhao Wang, Xu Chai, Xingang Liu, Kening Qiao, Yan Fu, Yanzhao Jin, Qingzhong Jia, Feng Zhu, Yang Zhang · 2024 · Journal of Chemical Information and Modeling
Could interleukin-15 potentiate histone deacetylase inhibitor effects in haematological malignancy?
Mihnea Zdrenghea · 2013 · Medical Hypotheses
Emerging drug targets in amyotrophic lateral sclerosis
Michael P. Bova, Gene G. Kinney · 2012 · Expert Opinion on Orphan Drugs
Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS
Claudia Avello Simões‐Pires, Vincent Zwick, Sylvian Cretton, Muriel Cuendet · 2017 · Journal of Visualized Experiments
Medicinal chemistry of histone deacetylase inhibitors
Dušan Ružić, Nemanja Djoković, Katarina M. Nikolic, Zorica B. Vujić · 2021 · Arhiv za farmaciju
Identification of Novel Histone Deacetylase 6‐Selective Inhibitors Bearing 3,3,3‐Trifluorolactic Amide (TFLAM) Motif as a Zinc Binding Group
Takashi Kurohara, Keita Tanaka, Daisuke Takahashi, Satoshi Ueda, Yasunobu Yamashita, Yuri Takada, Hirokazu Takeshima, Shengwang Yu, Yukihiro Itoh, Koji Hase et al. · 2021 · ChemBioChem
Effect of phenylurea hydroxamic acids on histone deacetylase and VEGFR-2
Szu Lee, Shih‐Wei Wang, Chen-Lin Yu, Huai‐Ching Tai, Juei-Yu Yen, Yu-Lien Tuan, Hsueh-Hsiao Wang, Yi-Ting Liu, Shiou-Sheng Chen, Hsueh‐Yun Lee · 2021 · Bioorganic & Medicinal Chemistry
Effects of tubastatin A on adrenocorticotropic hormone synthesis and proliferation of AtT-20 corticotroph tumor cells
Rie Hagiwara, Kazunori Kageyama, Yasumasa Iwasaki, Kanako Niioka, Makoto Daimon · 2022 · Endocrine Journal
Do biological activities of selective histone deacetylase 6 ( HDAC6 ) inhibitors rely on the modification of cap group?
Xingang Liu, Songsong Wang, Xiaoxing Shi, Ming Lü, Chengzhao Wang, Xuedong Li, Yang Zhang, Qingzhong Jia, Haisheng Liu · 2022 · Journal of Molecular Recognition
Design, synthesis and evaluation of antiproliferative activity of melanoma-targeted histone deacetylase inhibitors
Idris O. Raji, Kabir Ahluwalia, Adegboyega K. Oyelere · 2017 · Bioorganic & Medicinal Chemistry Letters
Centrosome–Microtubule Interactions in Health, Disease, and Disorders
Heide Schatten, Qing‐Yuan Sun · 2015 · Springer eBooks
Differential Effects of HDAC6 Inhibition Versus Knockout During Hepatic Ischemia–Reperfusion Injury Highlight Importance of HDAC6 C-terminal Zinc-finger Ubiquitin-binding Domain
Seth Jason Concors, Paul T. Hernandez, Ciaran O’Brien, John S. DePaolo, Douglas R. Murken, David D. Aufhauser, Zhonglin Wang, Yan Xiong, Lauren N. Krumeich, Guanghui Ge et al. · 2024 · Transplantation
Synthesis and Evaluation of 9-epi-Koshidacin B as Selective Inhibitor of Histone Deacetylase 1
Rajat Ghosh, Sima Biswas, Angshuman Bagchi, Shital Kumar Chattopadhyay · 2024 · Journal of Natural Products
Histone deacetylase 6 inhibitors in Alzheimer's disease therapy: structure design and challenges
Baiyun Dang, Hou Chen, Shiru Liu, Haijuan Liu, Zhiwen Kang, Zhen Yang, Weixia Yang, Jiadong Hu, Xin Chen · 2025 · Bioorganic & Medicinal Chemistry Letters
Treatment of Toxoplasmosis: An Insight on Epigenetic Drugs
Paolo Guglielmi, Daniela Secci · 2022 · Topics in medicinal chemistry
Mitochondrial NIR imaging probe mitigating oxidative damage by targeting HDAC6
Jungryun Kim, Paramesh Jangili, Jeongah Kim, Stephani Edwina Lucia, Jae Ryun Ryu, Renuka Prasad, Soyu Zi, Pilhan Kim, Woong Sun, Jong Seung Kim · 2023 · Chemical Communications
Biological and structural investigation of tetrahydro-β-carboline-based selective HDAC6 inhibitors with improved stability
Simon Scheuerer, L. Motlova, Linda Schäker‐Hübner, Andreas Sellmer, Felix Feller, Fabian J. Ertl, Pierre Koch, Finn Kristian Hansen, Cyril Bařinka, Siavosh Mahboobi · 2024 · European Journal of Medicinal Chemistry
Augmenting the Anti‐Leukemic Activity of the BCL‐2 Inhibitor Venetoclax Through Its Transformation Into Polypharmacologic Dual BCL‐2/HDAC1 and Dual BCL‐2/HDAC6 Inhibitors
Alexandria M. Chan, Christian L. Eberly, Brandon Drennen, Christopher C. Goodis, Zoe Wuyts, Curt I. Civin, Steven Fletcher · 2025 · Drug Development Research
Diagnostic and Therapeutic Implications of Histone Epigenetic Modulators in Breast Cancer
Louise Walsh, William M. Gallagher, Darran P. O’Connor, Tríona Ní Chonghaile · 2016 · Expert Review of Molecular Diagnostics
Acetylation of tubulin: A feasible protective target from neurodevelopment to neurodegeneration
Cappelletti Graziella, Daniele Cartelli · 2019 · Elsevier eBooks