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Cited by 285

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Self-Confirming “AND” Logic Nanoparticles for Fault-Free MRI

Open access
Choi, Jin-sil, Lee, Jae-Hyun, Shin, Tae-Hyun, Song, Ho-Taek, Kim, Eung Yeop, Cheon, Jinwoo·2010·Journal of the American Chemical Society

Abstract

Achieving high accuracy in the imaging of biological targets is a challenging issue. For MRI, to enhance imaging accuracy, two different imaging modes with specific contrast agents are used; one is a T1 type for a "positive" MRI signal and the other is a T2 type for a "negative" signal. Conventional contrast agents respond only in a single imaging mode and frequently encounter ambiguities in the MR images. Here, we propose a "magnetically decoupled" core-shell design concept to develop a dual mode nanoparticle contrast agent (DMCA). This DMCA not only possesses superior MR contrast effects but also has the unique capability of displaying "AND" logic signals in both the T1 and T2 modes. The latter enables self-confirmation of images and leads to greater diagnostic accuracy. A variety of novel DMCAs are possible, and the use of DMCAs can potentially bring the accuracy of MR imaging of diseases to a higher level.

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Metadata

Authors
Choi, J.-S., Lee, J.-H., Shin, T.-H., Song, H.-T., Kim, E. Y., & Cheon, J.
Venue
Journal of the American Chemical Society
Published
2010-07-27
Volume
132
Issue
32
Pages
11015-11017
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
OpenAlex
W2003443267
Cited by
285
References
1
FWCI
6.95
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Self-Confirming “AND” Logic Nanoparticles for Fault-Free MRI. https://app.cochat.ai/papers/10.1021/ja104503g
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Choi, J.-S., Lee, J.-H., Shin, T.-H., Song, H.-T., Kim, E. Y., & Cheon, J. (2010). Self-Confirming “AND” Logic Nanoparticles for Fault-Free MRI. Journal of the American Chemical Society. https://doi.org/10.1021/ja104503g

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