Designed synthesis of uniformly sized iron oxide nanoparticles for efficient magnetic resonance imaging contrast agents
Abstract
Various magnetic nanoparticles have been extensively investigated as novel magnetic resonance imaging (MRI) contrast agents owing to their unique characteristics, including efficient contrast effects, biocompatibility, and versatile surface functionalization capability. Nanoparticles with high relaxivity are very desirable because they would increase the accuracy of MRI. Recent progress in nanotechnology enables fine control of the size, crystal structure, and surface properties of iron oxide nanoparticles. In this tutorial review, we discuss how MRI contrast effects can be improved by controlling the size, composition, doping, assembly, and surface properties of iron-oxide-based nanoparticles.
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Upon surface modification, superparamagnetic iron oxide nanoparticles (SPION) can be employed for magnetic resonance imaging, magnetic particle imaging, targeted delivery of drugs, proteins, antibodies and nucleic acids, hyperthermia, biosensing, tissue repair, and separation of biomolecules.
“Upon surface-modification, the resulting superparamagnetic iron oxide nanoparticles (SPION) can be employed for magnetic resonance imaging (MRI) [4–8], magnetic particle imaging (MPI) [9–12], targeted delivery of drugs, proteins, antibodies, and nucleic acids [6, 7, 13, 14], hyperthermia [15–17], biosensing [18], tissue repair [19], and separation of biomolecules [20].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [8]
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- Authors
- Lee, N., & Hyeon, T.
- Affiliations
- Seoul National University (KR)
- Corresponding author
- Hyeon, Taeghwan
- Venue
- Chem. Soc. Rev.
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 41
- Issue
- 7
- Pages
- 2575-2589
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W1970954421
- Cited by
- 995
- References
- 63
- Citations by year
- 2026: 17 · 2025: 35 · 2024: 56 · 2023: 65 · 2022: 69 · 2021: 74 · 2020: 83 · 2019: 77 · 2018: 84 · 2017: 85 · 2016: 81 · 2015: 106 · 2014: 72 · 2013: 70 · 2012: 20
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemical Society Reviews (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Materials Science › Materials Chemistry › Magnetic Properties and Synthesis of Ferrites
- Physical Sciences › Materials Science › Materials Chemistry › Lanthanide and Transition Metal Complexes
- Keywords
- iron oxide nanoparticles, MRI contrast agents, relaxivity, nanoparticle size control, doping, surface functionalization, nanoparticle assembly, crystal structure, biocompatibility
- MeSH terms
- Contrast Media, Ferric Compounds, Humans, Magnetic Resonance Imaging, Magnetics, Particle Size, Surface Properties, Metal Nanoparticles
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