The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Dynamics of Unfolded Protein Transport through an Aerolysin Pore
Open accessAbstract
Protein export is an essential mechanism in living cells and exported proteins are usually translocated through a protein-conducting channel in an unfolded state. Here we analyze, by electrical detection, the entry and transport of unfolded proteins, at the single molecule level, with different stabilities through an aerolysin pore, as a function of the applied voltage and protein concentration. The frequency of ionic current blockades varies exponentially as a function of the applied voltage and linearly as a function of protein concentration. The transport time of unfolded proteins decreases exponentially when the applied voltage increases. We prove that the ionic current blockade duration of a double-sized protein is longer than that assessed for a single protein supporting the transport phenomenon. Our results fit with the theory of confined polyelectrolyte and with some experimental results about DNA or synthetic polyelectrolyte translocation through protein channels as a function of applied voltage. We discuss the potential of the aerolysin nanopore as a tool for protein folding studies as it has already been done for α-hemolysin.
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Citations
Cites
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
Rapoport, T. A. (2007) · Nature · doi:10.1038/nature06384 · Cited by 977
Protein translocation across biological membranes
Wickner, W., & Schekman, R. (2005) · Science · doi:10.1126/science.1113752 · Cited by 458
Cited by
Paving the way to single-molecule protein sequencing
Restrepo-Pérez, L., Joo, C., & Dekker, C. (2018) · Nature Nanotechnology · doi:10.1038/s41565-018-0236-6 · Cited by 396
Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory
Cournia, Z., Allen, T. W., Andricioaei, I., Antonny, B., Baum, D., Brannigan, G., Buchete, N.-V., Deckman, J. T., Delemotte, L., del Val, C., et al. (2015) · The Journal of Membrane Biology · doi:10.1007/s00232-015-9802-0 · Cited by 235
Breton, M. F., Discala, F., Bacri, L., Foster, D., Pelta, J., & Oukhaled, A. (2013) · The Journal of Physical Chemistry Letters · doi:10.1021/jz400938q · Cited by 63
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Metadata
- Authors
- Pastoriza-Gallego, M., Rabah, L., Gibrat, G., Thiebot, B., van der Goot, F. G., Auvray, L., Betton, J.-M., & Pelta, J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-02-14
- Volume
- 133
- Issue
- 9
- Pages
- 2923-2931
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2091941153
- Cited by
- 241
- References
- 2
- FWCI
- 9.85
- Type
- journal article
- Language
- en
- Open access
- green
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- Pastoriza-Gallego, M., Rabah, L., Gibrat, G., Thiebot, B., van der Goot, F. G., Auvray, L., Betton, J.-M., & Pelta, J. (2011). Dynamics of Unfolded Protein Transport through an Aerolysin Pore. Journal of the American Chemical Society. https://doi.org/10.1021/ja1073245
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