Cited by 236Lipid Membrane Structure and BehaviorProtein Structure and DynamicsIon channel regulation and function

Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory

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Cournia, Zoe, Allen, Toby W., Andricioaei, Ioan, Antonny, Bruno, Baum, Daniel, Brannigan, Grace, Buchete, Nicolae-Viorel, Deckman, Jason T. +21 more·2015·The Journal of Membrane Biology

Abstract

Membrane proteins mediate processes that are fundamental for the flourishing of biological cells. Membrane-embedded transporters move ions and larger solutes across membranes; receptors mediate communication between the cell and its environment and membrane-embedded enzymes catalyze chemical reactions. Understanding these mechanisms of action requires knowledge of how the proteins couple to their fluid, hydrated lipid membrane environment. We present here current studies in computational and experimental membrane protein biophysics, and show how they address outstanding challenges in understanding the complex environmental effects on the structure, function, and dynamics of membrane proteins.

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  • Dynamic interconversion between multiple conformations underpins the functions of integral membrane proteins in all domains of life.

    “Dynamic interconversion between multiple conformations underpins the functions of integral membrane proteins in all domains of life (Campbell et al., 2016; Cournia et al., 2015; Shaw et al., 2010; Boehr et al., 2009).”

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  1. Barghorn S Nimmrich V Striebinger A Krantz C Keller P Janson B Bahr M Schmidt M Bitner R Harlan J Barlow E Ebert U Hillen H 2005 Globular amyloid beta-peptide oligomer-a homogenous and stable neuropathological protein in A lzheimer’s disease J Neurochem 95 834 847 16135089
  2. Friedman R Caflisch A 2014 Wild type and mutants of the HET-s(218–289) prion show different flexibility at fibrillar ends: A simulation study Proteins 82 399 404 24038616
  3. Optimization of receptor-G protein coupling by bilayer lipid composition I: kinetics of rhodopsin-transducin binding J Biol Chem, United States 42807 11 11544258
  4. Suh BC Hille B 2008 PIP2 is a necessary cofactor for ion channel function: how and why? Annu Rev Biophys 37 175 95 18573078 PMC2692585
  5. Wales D 2003 Energy Landscapes Cambridge University Press Cambridge

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Authors
Cournia, Z., Allen, T. W., Andricioaei, I., Antonny, B., Baum, D., Brannigan, G., Buchete, N.-V., Deckman, J. T., Delemotte, L., del Val, C., Friedman, R., Gkeka, P., Hege, H.-C., Hénin, J., Kasimova, M. A., Kolocouris, A., Klein, M. L., Khalid, S., Lemieux, M. J., Lindow, N., Roy, M., Selent, J., Tarek, M., Tofoleanu, F., Vanni, S., Urban, S., Wales, D. J., Smith, J. C., & Bondar, A.-N.
Affiliations
  • Academy of Athens (GR)
  • RMIT University (AU)
  • University of California, Irvine (US)
  • Centre National de la Recherche Scientifique (FR)
  • Zuse Institute Berlin (DE)
  • Rutgers, The State University of New Jersey (US)
  • University College Dublin (IE)
  • Temple University (US)
  • Linnaeus University (SE)
  • Lomonosov Moscow State University (RU)
  • National and Kapodistrian University of Athens (GR)
  • University of Southampton (GB)
  • University of Alberta (CA)
  • Universitat Pompeu Fabra (ES)
  • University of Cambridge (GB)
  • Oak Ridge National Laboratory (US)
  • Freie Universität Berlin (DE)
Corresponding author
  • Cournia, Zoe
  • Smith, Jeremy C.
  • Bondar, Ana-Nicoleta
Venue
The Journal of Membrane Biology
Published
2015-06-11
Volume
248
Issue
4
Pages
611-640
ISSN
  • 0022-2631 (ISSN-L)
  • 1432-1424
OpenAlex
W2103496068
Cited by
235
References
282
Citations by year
2026: 11 · 2025: 23 · 2024: 36 · 2023: 37 · 2022: 18 · 2021: 28 · 2020: 27 · 2019: 15 · 2018: 18 · 2017: 12 · 2016: 10
FWCI
1.29
Type
journal article
Language
en
Open access
Locations
  • The Journal of Membrane Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • RECERCAT (Consorci de Serveis Universitaris de Catalunya) (acceptedVersion, other-oa)
  • OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
  • Rutgers University Community Repository (Rutgers University) (submittedVersion)
  • HAL (submittedVersion, public-domain)
  • RMIT Research Repository (RMIT University Library) (submittedVersion)
  • ePrints Soton (University of Southampton) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
  • Figshare (submittedVersion)
  • Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion)
Funders
  • National Science Foundation (1052477, RC2GM093307, 0840513)
  • National Institutes of Health
  • University of California, Irvine
  • Australian Research Council (DP120103548)
  • European Regional Development Fund
  • National Cancer Institute (2010-1)
  • National Institute of General Medical Sciences (P01GM55876-14A1, P01GM055876, RC2GM093307)
  • Division of Chemistry (CHE-0840513)
  • FP7 Ideas: European Research Council (268888)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords
membrane proteins, membrane protein structure, membrane protein dynamics, membrane protein function, membrane transporters, cell surface receptors, protein-lipid interactions, computational biophysics
MeSH terms
Animals, Humans, Models, Biological, Models, Chemical, Structure-Activity Relationship, Protein Structure, Tertiary, Membrane Transport Proteins

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