The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Aqueous Dispersion Polymerization: A New Paradigm for in Situ Block Copolymer Self-Assembly in Concentrated Solution
Abstract
Reversible addition-fragmentation chain transfer polymerization has been utilized to polymerize 2-hydroxypropyl methacrylate (HPMA) using a water-soluble macromolecular chain transfer agent based on poly(2-(methacryloyloxy)ethylphosphorylcholine) (PMPC). A detailed phase diagram has been elucidated for this aqueous dispersion polymerization formulation that reliably predicts the precise block compositions associated with well-defined particle morphologies (i.e., pure phases). Unlike the ad hoc approaches described in the literature, this strategy enables the facile, efficient, and reproducible preparation of diblock copolymer spheres, worms, or vesicles directly in concentrated aqueous solution. Chain extension of the highly hydrated zwitterionic PMPC block with HPMA in water at 70 °C produces a hydrophobic poly(2-hydroxypropyl methacrylate) (PHPMA) block, which drives in situ self-assembly to form well-defined diblock copolymer spheres, worms, or vesicles. The final particle morphology obtained at full monomer conversion is dictated by (i) the target degree of polymerization of the PHPMA block and (ii) the total solids concentration at which the HPMA polymerization is conducted. Moreover, if the targeted diblock copolymer composition corresponds to vesicle phase space at full monomer conversion, the in situ particle morphology evolves from spheres to worms to vesicles during the in situ polymerization of HPMA. In the case of PMPC(25)-PHPMA(400) particles, this systematic approach allows the direct, reproducible, and highly efficient preparation of either block copolymer vesicles at up to 25% solids or well-defined worms at 16-25% solids in aqueous solution.
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Cites
Radical addition–fragmentation chemistry in polymer synthesis
Moad, G., Rizzardo, E., & Thang, S. H. (2008) · Polymer · doi:10.1016/j.polymer.2007.11.020 · Cited by 1,397
The convergence of synthetic organic and polymer chemistries
Hawker, C. J., & Wooley, K. L. (2005) · Science · doi:10.1126/science.1109778 · Cited by 1,298
On the origins of morphological complexity in block copolymer surfactants
Jain, S., & Bates, F. S. (2003) · Science · doi:10.1126/science.1082193 · Cited by 1,217
Cited by
Sterilizable Gels from Thermoresponsive Block Copolymer Worms
Blanazs, A., Verber, R., Mykhaylyk, O. O., Ryan, A. J., Heath, J. Z., Douglas, C. W. I., & Armes, S. P. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3024059 · Cited by 396
Self-citationRieger, J. (2015) · Macromolecular Rapid Communications · doi:10.1002/marc.201500028 · Cited by 349
Thermo-responsive Diblock Copolymer Worm Gels in Non-polar Solvents
Fielding, L. A., Lane, J. A., Derry, M. J., Mykhaylyk, O. O., & Armes, S. P. (2014) · Journal of the American Chemical Society · doi:10.1021/ja501756h · Cited by 309
Self-citationSelf-Assembly of Copolymer Micelles: Higher-Level Assembly for Constructing Hierarchical Structure
Lu, Y., Lin, J., Wang, L., Zhang, L., & Cai, C. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00774 · Cited by 281
A biomimetic magnetosome: Formation of iron oxide within carboxylic acid terminated polymersomes
Bain, J., Legge, C. J., Beattie, D. L., Sahota, A., Dirks, C., Lovett, J. R., & Staniland, S. S. (2019) · Nanoscale · doi:10.1039/c9nr00498j · Cited by 21
Metadata
- Authors
- Sugihara, S., Blanazs, A., Armes, S. P., Ryan, A. J., & Lewis, A. L.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-09-08
- Volume
- 133
- Issue
- 39
- Pages
- 15707-15713
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2024560266
- Cited by
- 431
- References
- 3
- FWCI
- 13.62
- Type
- journal article
- Language
- en
- Open access
- closed
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