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A Chemical Approach for Cell-Specific Targeting of Nanomaterials: Small-Molecule-Initiated Misfolding of Nanoparticle Corona Proteins

Prapainop, Kanlaya, Witter, Daniel P., Wentworth, Paul·2012·Journal of the American Chemical Society
DOI 10.1021/ja300537u
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Abstract

A major challenge in nanomaterial science is to develop approaches that ensure that when administered in vivo, nanoparticles can be targeted to their requisite site of action. Herein we report the first approach that allows for cell-specific uptake of nanomaterials by a process involving reprogramming of the behavior of the ubiquitous protein corona of nanomaterials. Specifically, judicious surface modification of quantum dots with a small molecule that induces a protein-misfolding event in a component of the nanoparticle-associated protein corona renders the associated nanomaterials susceptible to cell-specific, receptor-mediated endocytosis. We see this chemical approach as a new and general method for exploiting the inescapable protein corona to target nanomaterials to specific cells.

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Research works printed but not linked: 23

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Metadata

Authors
Prapainop, K., Witter, D. P., & Wentworth, P.
Venue
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Published
2012-02-27
Volume
134
Issue
9
Pages
4100-4103
ISSN
  • 0002-7863
  • 1520-5126
DOI
10.1021/ja300537u
Cited by
105
References
0
Language
en

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CoChat. (2026). Citation check: A Chemical Approach for Cell-Specific Targeting of Nanomaterials: Small-Molecule-Initiated Misfolding of Nanoparticle Corona Proteins. https://app.cochat.ai/papers/10.1021/ja300537u
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Prapainop, K., Witter, D. P., & Wentworth, P. (2012). A Chemical Approach for Cell-Specific Targeting of Nanomaterials: Small-Molecule-Initiated Misfolding of Nanoparticle Corona Proteins. Journal of the American Chemical Society. https://doi.org/10.1021/ja300537u