The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Selective Detection of the Reduced Form of Glutathione (GSH) over the Oxidized (GSSG) Form Using a Combination of Glutathione Reductase and a Tb(III)-Cyclen Maleimide Based Lanthanide Luminescent ‘Switch On’ Assay
Abstract
The synthesis of a novel Tb(III) luminescent probe for the detection of thiols is presented. The probe 1.Tb, possessing a maleimide moiety, as its sulfhydryl acceptor, was poorly emitting in aqueous pH 7 solution in the absence of a thiol. However, upon addition of thiols such as glutathione (GSH), large enhancements were observed, particularly within the physiological pH range. In contrast no enhancements were observed in the presence of the oxidized form of glutathione (GSSG), except in the presence of the enzyme glutathione reductase and NADPH which enabled 1.Tb to be used to observe the enzymatic reduction of GSSG to GSH in real time.
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Citations
Cites
Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease
Seshadri, S., Beiser, A., Selhub, J., Jacques, P. F., Rosenberg, I. H., D'Agostino, R. B., Wilson, P. W. F., & Wolf, P. A. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011613 · Cited by 3,237
Homocysteine and Cardiovascular Disease
Refsum, H., Ueland, P. M., Nygård, O., & Vollset, S. E. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.31 · Cited by 2,180
Fluorescent and colorimetric probes for detection of thiols
Chen, X., Zhou, Y., Peng, X., & Yoon, J. (2010) · Chemical Society Reviews · doi:10.1039/b925092a · Cited by 1,580
Cited by
Design strategies of fluorescent probes for selective detection among biothiols
Niu, L.-Y., Chen, Y.-Z., Zheng, H.-R., Wu, L.-Z., Tung, C.-H., & Yang, Q.-Z. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00152h · Cited by 870
Thiol-addition reactions and their applications in thiol recognition
Yin, C., Huo, F., Zhang, J., Martínez-Máñez, R., Yang, Y., Lv, H., & Li, S. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60055f · Cited by 554
A Reversible Fluorescent Probe for Real‐Time Quantitative Monitoring of Cellular Glutathione
Liu, Z., Zhou, X., Miao, Y., Hu, Y., Kwon, N., Wu, X., & Yoon, J. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201702114 · Cited by 312
Metadata
- Authors
- McMahon, B. K., & Gunnlaugsson, T.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-04-02
- Volume
- 134
- Issue
- 26
- Pages
- 10725-10728
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2332928565
- Cited by
- 261
- References
- 3
- FWCI
- 9.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Selective Detection of the Reduced Form of Glutathione (GSH) over the Oxidized (GSSG) Form Using a Combination of Glutathione Reductase and a Tb(III)-Cyclen Maleimide Based Lanthanide Luminescent ‘Switch On’ Assay. https://app.cochat.ai/papers/10.1021/ja300887k
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- McMahon, B. K., & Gunnlaugsson, T. (2012). Selective Detection of the Reduced Form of Glutathione (GSH) over the Oxidized (GSSG) Form Using a Combination of Glutathione Reductase and a Tb(III)-Cyclen Maleimide Based Lanthanide Luminescent ‘Switch On’ Assay. Journal of the American Chemical Society. https://doi.org/10.1021/ja300887k
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