The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
A Reversible Fluorescent Probe for Real‐Time Quantitative Monitoring of Cellular Glutathione
Abstract
The ability to monitor and quantify glutathione (GSH) in live cells is essential in order to gain a detailed understanding of GSH‐related pathological events. However, owing to their irreversible response mechanisms, most existing fluorescent GSH probes are not suitable for this purpose. We have developed a ratiometric fluorescent probe (QG‐1) for quantitatively monitoring cellular GSH. The probe responds specifically and reversibility to GSH with an ideal dissociation constant (Kd) of 2.59 m m and a fast response time (t1/2=5.82 s). We also demonstrate that QG‐1 detection of GSH is feasible in a model protein system. QG‐1 was found to have extremely low cytotoxicity and was applied to determine the GSH concentration in live HeLa cells (5.40±0.87 m m).
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Cites
Schafer, F. Q., & Buettner, G. R. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00480-4 · Cited by 4,587
Glutathione Metabolism and Its Implications for Health
Wu, G., Lupton, J. R., Turner, N. D., Fang, Y.-Z., & Yang, S. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.3.489 · Cited by 3,842
Reactive oxygen species, cellular redox systems, and apoptosis
Circu, M. L., & Aw, T. Y. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.022 · Cited by 3,340
Macromolecular crowding: obvious but underappreciated
Ellis, R. J. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)01938-7 · Cited by 2,309
Zhou, H.-X., Rivas, G., & Minton, A. P. (2008) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.37.032807.125817 · Cited by 2,149
Hussain, S. P., Hofseth, L. J., & Harris, C. C. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1046 · Cited by 1,690
Extrinsic Fluorescent Dyes as Tools for Protein Characterization
Hawe, A., Sutter, M., & Jiskoot, W. (2008) · Pharmaceutical Research · doi:10.1007/s11095-007-9516-9 · Cited by 1,199
Macromolecular crowding: an important but neglected aspect of the intracellular environment
Ellis, R. J. (2001) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(00)00172-x · Cited by 1,153
Glutathione in Cancer Biology and Therapy
Estrela, J. M., Ortega, A., & Obrador, E. (2006) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360500523878 · Cited by 1,041
Real-time imaging of the intracellular glutathione redox potential
Gutscher, M., Pauleau, A.-L., Marty, L., Brach, T., Wabnitz, G. H., Samstag, Y., Meyer, A. J., & Dick, T. P. (2008) · Nature Methods · doi:10.1038/nmeth.1212 · Cited by 894
Cited by
Multicharged cyclodextrin supramolecular assemblies
Liu, Z., & Liu, Y. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00821h · Cited by 270
Self-citationJiang, C., Zhang, L., Xu, X., Qi, M., Zhang, J., He, S., Tian, Q., & Song, S. (2021) · Advanced Science · doi:10.1002/advs.202102500 · Cited by 77
A Substituted‐Rhodamine‐Based Reversible Fluorescent Probe for In Vivo Quantification of Glutathione
Li, N., Wang, T., Wang, N., Fan, M., & Cui, X. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202217326 · Cited by 68
Zhao, Y., Li, L., Ye, Q., Gong, Y., Yang, R., & Liu, H. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c02664 · Cited by 47
Pan, Y., Lei, S., Zhang, J., Qu, J., Huang, P., & Lin, J. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c04504 · Cited by 45
Metadata
- Authors
- Liu, Z., Zhou, X., Miao, Y., Hu, Y., Kwon, N., Wu, X., & Yoon, J.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2017-03-28
- Volume
- 56
- Issue
- 21
- Pages
- 5812-5816
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2598958389
- Cited by
- 312
- References
- 48
- FWCI
- 16.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liu, Z., Zhou, X., Miao, Y., Hu, Y., Kwon, N., Wu, X., & Yoon, J. (2017). A Reversible Fluorescent Probe for Real‐Time Quantitative Monitoring of Cellular Glutathione. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201702114
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
