The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Several small molecules have been shown to bind to the hydrophobic pocket of Y220C and restore p53 function467–478”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [469]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Kabsch, W. (2010) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444909047337 · Cited by 16,463
Development and validation of a genetic algorithm for flexible docking 1 1Edited by F. E. Cohen
Jones, G., Willett, P., Glen, R. C., Leach, A. R., & Taylor, R. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1996.0897 · Cited by 6,763
PHENIX : building new software for automated crystallographic structure determination
Adams, P. D., Grosse-Kunstleve, R. W., Hung, L.-W., Ioerger, T. R., McCoy, A. J., Moriarty, N. W., Read, R. J., Sacchettini, J. C., Sauter, N. K., & Terwilliger, T. C. (2002) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444902016657 · Cited by 4,361
Petitjean, A., Mathe, E., Kato, S., Ishioka, C., Tavtigian, S. V., Hainaut, P., & Olivier, M. (2007) · Human Mutation · doi:10.1002/humu.20495 · Cited by 1,598
Awakening guardian angels: drugging the p53 pathway
Brown, C. J., Lain, S., Verma, C. S., Fersht, A. R., & Lane, D. P. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2763 · Cited by 881
Self-citation
Research works printed but not linked: 29
- Lu Y., 2009, J. Med. Chem., 52, 2854, 10.1021/jm9000133 · DOI · Paper page
- Xu Z., 2011, J. Med. Chem., 54, 5607, 10.1021/jm200644r · DOI
- Clark T., 2007, J. Mol. Model., 13, 291, 10.1007/s00894-006-0130-2 · DOI · Paper page
- Grasberger B. L., 2005, J. Med. Chem., 48, 909, 10.1021/jm049137g · DOI · Paper page
- Parks D. J., 2005, Bioorg. Med. Chem. Lett., 15, 765, 10.1016/j.bmcl.2004.11.009 · DOI
- Fedorov O., 2011, Chem. Biol., 18, 67, 10.1016/j.chembiol.2010.11.009 · DOI · Paper page
- Hardegger L. A., 2011, ChemMedChem, 6, 2048, 10.1002/cmdc.201100353 · DOI
- Lu Y., 2010, Phys. Chem. Chem. Phys., 12, 4543, 10.1039/b926326h · DOI · Paper page
- Wilcken R., 2011, J. Chem. Theory Comput., 7, 2307, 10.1021/ct200245e · doi:10.1021/ct200245e
- Joerger A. C., 2010, Cold Spring Harb. Perspect. Biol., 2, a000919, 10.1101/cshperspect.a000919 · DOI · Paper page
- Wiman K. G., 2010, Oncogene, 29, 4245, 10.1038/onc.2010.188 · DOI · Paper page
- Popowicz G. M., 2011, Angew. Chem., Int. Ed., 50, 2680, 10.1002/anie.201003863 · DOI · Paper page
- Joerger A. C., 2007, Oncogene, 26, 2226, 10.1038/sj.onc.1210291 · DOI · Paper page
- Bullock A. N., 2000, Oncogene, 19, 1245, 10.1038/sj.onc.1203434 · DOI · Paper page
- Friedler A., 2003, J. Biol. Chem., 278, 24108, 10.1074/jbc.M302458200 · DOI · Paper page
- Joerger A. C., 2006, Proc. Natl. Acad. Sci. U.S.A., 103, 15056, 10.1073/pnas.0607286103 · DOI · Paper page
- Boeckler F. M., 2008, Proc. Natl. Acad. Sci. U.S.A., 105, 10360, 10.1073/pnas.0805326105 · DOI · Paper page
- Basse N., 2010, Chem. Biol., 17, 46, 10.1016/j.chembiol.2009.12.011 · DOI · Paper page
- Congreve M., 2003, Drug Discovery Today, 8, 876, 10.1016/S1359-6446(03)02831-9 · DOI · Paper page
- Hardegger L. A., 2011, Angew. Chem., Int. Ed., 50, 314, 10.1002/anie.201006781 · DOI · Paper page
- Hopkins A. L., 2004, Drug Discovery Today, 9, 430, 10.1016/S1359-6446(04)03069-7 · DOI · Paper page
- Sonogashira K., 1975, Tetrahedron Lett., 16, 4467, 10.1016/S0040-4039(00)91094-3 · DOI · Paper page
- Doucet H., 2007, Angew. Chem., Int. Ed., 46, 834, 10.1002/anie.200602761 · DOI · Paper page
- GOLD,version 3.2;The Cambridge Crystallographic Data Centre (CCDC):Cambridge, U.K, 2005.
- Eldridge M. D., 1997, J. Comput.-Aided Mol. Des., 11, 425, 10.1023/A:1007996124545 · DOI · Paper page
- Vogel S. M., 2011, J. Chem. Inf. Model., 51, 2650, 10.1021/ci2001549 · DOI
- Leslie A. G., 1999, Acta Crystallogr., Sect. D: Biol. Crystallogr., 55, 1696, 10.1107/S090744499900846X · DOI · Paper page
- Evans P., 2006, Acta Crystallogr., Sect. D: Biol. Crystallogr., 62, 72, 10.1107/S0907444905036693 · DOI · Paper page
- Emsley P., 2010, Acta Crystallogr., Sect. D: Biol. Crystallogr., 66, 486, 10.1107/S0907444910007493 · DOI · Paper page
Cited by
Dixon, S. J., Patel, D. N., Welsch, M., Skouta, R., Lee, E. D., Hayano, M., Thomas, A. G., Gleason, C. E., Tatonetti, N. P., Slusher, B. S., et al. (2014) · eLife · doi:10.7554/elife.02523 · Cited by 2,088
Targeting p53 pathways: mechanisms, structures, and advances in therapy
Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016
Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human Diseases
Uversky, V. N., Davé, V., Iakoucheva, L. M., Malaney, P., Metallo, S. J., Pathak, R. R., & Joerger, A. C. (2014) · Chemical Reviews · doi:10.1021/cr400713r · Cited by 288
Self-citationSoteras Gutiérrez, I., Lin, F.-Y., Vanommeslaeghe, K., Lemkul, J. A., Armacost, K. A., Brooks, C. L., & MacKerell, A. D. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2016.06.034 · Cited by 283
Bauer, M. R., Ibrahim, T. M., Vogel, S. M., & Boeckler, F. M. (2013) · Journal of Chemical Information and Modeling · doi:10.1021/ci400115b · Cited by 200
Self-citation
Metadata
- Authors
- Wilcken, R., Liu, X., Zimmermann, M. O., Rutherford, T. J., Fersht, A. R., Joerger, A. C., & Boeckler, F. M.
- Affiliations
- Laboratory for Molecular Design and Pharmaceutical Biophysics, Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard-Karls-University Tuebingen, Auf der Morgenstelle 8, 72076 Tuebingen, Germany
- MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, United Kingdom
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-04-05
- Volume
- 134
- Issue
- 15
- Pages
- 6810-6818
- ISSN
- 0002-7863
- 1520-5126
- Cited by
- 235
- References
- 5
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
