The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Designed Diblock Oligonucleotide for the Synthesis of Spatially Isolated and Highly Hybridizable Functionalization of DNA–Gold Nanoparticle Nanoconjugates
Abstract
Conjugates of DNA and gold nanoparticles (AuNPs) typically exploit the strong Au-S chemistry to self-assemble thiolated oligonucleotides at AuNPs. However, it remains challenging to precisely control the orientation and conformation of surface-tethered oligonucleotides and finely tune the hybridization ability. We herein report a novel strategy for spatially controlled functionalization of AuNPs with designed diblock oligonucleotides that are free of modifications. We have demonstrated that poly adenine (polyA) can serve as an effective anchoring block for preferential binding with the AuNP surface, and the appended recognition block adopts an upright conformation that favors DNA hybridization. The lateral spacing and surface density of DNA on AuNPs can also be systematically modulated by adjusting the length of the polyA block. Significantly, this diblock oligonucleotide strategy results in DNA-AuNPs nanoconjugates with high and tunable hybridization ability, which form the basis of a rapid plasmonic DNA sensor.
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Cites
A DNA-based method for rationally assembling nanoparticles into macroscopic materials
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Nanoparticles with Raman Spectroscopic Fingerprints for DNA and RNA Detection
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Functional Nucleic Acid Sensors
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Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation
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Cited by
Functional DNA Nanostructures for Theranostic Applications
Pei, H., Zuo, X., Zhu, D., Huang, Q., & Fan, C. (2014) · Accounts of Chemical Research · doi:10.1021/ar400195t · Cited by 409
Self-citationHu, M., Yuan, C., Tian, T., Wang, X., Sun, J., Xiong, E., & Zhou, X. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c00217 · Cited by 267
Metadata
- Authors
- Pei, H., Li, F., Wan, Y., Wei, M., Liu, H., Su, Y., Chen, N., Huang, Q., & Fan, C.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-07-16
- Volume
- 134
- Issue
- 29
- Pages
- 11876-11879
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2029932108
- Cited by
- 553
- References
- 35
- FWCI
- 9.87
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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