The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation
Abstract
We describe the use of gold nanoparticle-oligonucleotide complexes as intracellular gene regulation agents for the control of protein expression in cells. These oligonucleotide-modified nanoparticles have affinity constants for complementary nucleic acids that are higher than their unmodified oligonucleotide counterparts, are less susceptible to degradation by nuclease activity, exhibit greater than 99% cellular uptake, can introduce oligonucleotides at a higher effective concentration than conventional transfection agents, and are nontoxic to the cells under the conditions studied. By chemically tailoring the density of DNA bound to the surface of gold nanoparticles, we demonstrated a tunable gene knockdown.
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Citations
Cites
Nanostructures in Biodiagnostics
Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603
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Cited by
Nonviral vectors for gene delivery
Mintzer, M. A., & Simanek, E. E. (2009) · Chemical Reviews · doi:10.1021/cr800409e · Cited by 2,366
Gold Nanorods: From Synthesis and Properties to Biological and Biomedical Applications
Huang, X., Neretina, S., & El‐Sayed, M. A. (2009) · Advanced Materials · doi:10.1002/adma.200802789 · Cited by 1,921
Applications of Nanoparticles in Biology
De, M., Ghosh, P. S., & Rotello, V. M. (2008) · Advanced Materials · doi:10.1002/adma.200703183 · Cited by 1,547
Laser Synthesis and Processing of Colloids: Fundamentals and Applications
Zhang, D., Gökce, B., & Barcikowski, S. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00468 · Cited by 1,344
Programmable materials and the nature of the DNA bond
Jones, M. R., Seeman, N. C., & Mirkin, C. A. (2015) · Science · doi:10.1126/science.1260901 · Cited by 1,347
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Metadata
- Authors
- Rosi, N. L., Giljohann, D. A., Thaxton, C. S., Lytton-Jean, A. K. R., Han, M. S., & Mirkin, C. A.
- Venue
- Science
- Published
- 2006-05-19
- Volume
- 312
- Issue
- 5776
- Pages
- 1027-1030
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2009993736
- Cited by
- 1,988
- References
- 1
- FWCI
- 30.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rosi, N. L., Giljohann, D. A., Thaxton, C. S., Lytton-Jean, A. K. R., Han, M. S., & Mirkin, C. A. (2006). Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation. Science. https://doi.org/10.1126/science.1125559
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
