The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Nanoscale Graphene Oxide (nGO) as Artificial Receptors: Implications for Biomolecular Interactions and Sensing
Open accessAbstract
The role of conventional graphene-oxide in biosensing has been limited to that of a quenching substrate or signal transducer due to size inconsistencies and poor supramolecular response. We overcame these issues by using nanoscale GOs (nGO) as artificial receptors. Unlike conventional GO, nGOs are sheets with near uniform lateral dimension of 20 nm. Due to its nanoscale architecture, its supramolecular response was enhanced, with demonstrated improvements in biomacromolecular affinities. This rendered their surface capable of detecting unknown proteins with cognizance not seen with conventional GOs. Different proteins at 100 and 10 nM concentrations revealed consistent patterns that are quantitatively differentiable by linear discriminant analysis. Identification of 48 unknowns in both concentrations demonstrated a >95% success rate. The 10 nM detection represents a 10-fold improvement over analogous arrays. This demonstrates for the first time that the supramolecular chemistry of GO is highly size dependent and opens the possibility of improvement upon existing GO hybrid materials.
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Cites
Noncovalent sidewall functionalization of single-walled carbon nanotubes for protein immobilization
Chen, R. J., Zhang, Y., Wang, D., & Dai, H. (2001) · Journal of the American Chemical Society · doi:10.1021/ja010172b · Cited by 2,534
Narrow graphene nanoribbons from carbon nanotubes
Jiao, L., Zhang, L., Wang, X., Diankov, G., & Dai, H. (2009) · Nature · doi:10.1038/nature07919 · Cited by 2,441
Luo, J., Cote, L. J., Tung, V. C., Tan, A. T. L., Goins, P. E., Wu, J., & Huang, J. (2010) · Journal of the American Chemical Society · doi:10.1021/ja1078943 · Cited by 389
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Cited by
Graphene-based materials for tissue engineering
Shin, S. R., Li, Y.-C., Jang, H. L., Khoshakhlagh, P., Akbari, M., Nasajpour, A., Zhang, Y. S., Tamayol, A., & Khademhosseini, A. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.03.007 · Cited by 721
Carbon-based nanomaterials as an emerging platform for theranostics
Patel, K. D., Singh, R. K., & Kim, H.-W. (2019) · Materials Horizons · doi:10.1039/c8mh00966j · Cited by 555
Ryoo, S.-R., Lee, J., Yeo, J., Na, H.-K., Kim, Y.-K., Jang, H., Lee, J. H., Han, S. W., Lee, Y., Kim, V. N., et al. (2013) · ACS Nano · doi:10.1021/nn401183s · Cited by 309
Metadata
- Authors
- Chou, S. S., De, M., Luo, J., Rotello, V. M., Huang, J., & Dravid, V. P.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-09-26
- Volume
- 134
- Issue
- 40
- Pages
- 16725-16733
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2132104402
- Cited by
- 192
- References
- 3
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- green
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