The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Quantitative and Multiplexed MicroRNA Sensing in Living Cells Based on Peptide Nucleic Acid and Nano Graphene Oxide (PANGO)
Abstract
MicroRNA (miRNA) is an important small RNA which regulates diverse gene expression at the post-transcriptional level. miRNAs are considered as important biomarkers since abnormal expression of specific miRNAs is associated with many diseases including cancer and diabetes. Therefore, it is important to develop biosensors to quantitatively detect miRNA expression levels. Here, we develop a nanosized graphene oxide (NGO) based miRNA sensor, which allows quantitative monitoring of target miRNA expression levels in living cells. The strategy is based on tight binding of NGO with peptide nucleic acid (PNA) probes, resulting in fluorescence quenching of the dye that is conjugated to the PNA, and subsequent recovery of the fluorescence upon addition of target miRNA. PNA as a probe for miRNA sensing offers many advantages including high sequence specificity, high loading capacity on the NGO surface compared to DNA and resistance against nuclease-mediated degradation. The present miRNA sensor allowed the detection of specific target miRNAs with the detection limit as low as ~1 pM and the simultaneous monitoring of three different miRNAs in a living cell.
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Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
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MicroRNAs: small RNAs with a big role in gene regulation
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MicroRNA Gene Expression Deregulation in Human Breast Cancer
Iorio, M. V., Ferracin, M., Liu, C.-G., Veronese, A., Spizzo, R., Sabbioni, S., Magri, E., Pedriali, M., Fabbri, M., Campiglio, M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1783 · Cited by 4,053
MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells
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PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules
Egholm, M., Buchardt, O., Christensen, L., Behrens, C., Freier, S. M., Driver, D. A., Berg, R. H., Kim, S. K., Norden, B., & Nielsen, P. E. (1993) · Nature · doi:10.1038/365566a0 · Cited by 2,079
A Graphene Platform for Sensing Biomolecules
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MicroRNA profiling: approaches and considerations
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Metadata
- Authors
- Ryoo, S.-R., Lee, J., Yeo, J., Na, H.-K., Kim, Y.-K., Jang, H., Lee, J. H., Han, S. W., Lee, Y., Kim, V. N., & Min, D.-H.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-06-19
- Volume
- 7
- Issue
- 7
- Pages
- 5882-5891
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2082005641
- Cited by
- 309
- References
- 31
- FWCI
- 13.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ryoo, S.-R., Lee, J., Yeo, J., Na, H.-K., Kim, Y.-K., Jang, H., Lee, J. H., Han, S. W., Lee, Y., Kim, V. N., & Min, D.-H. (2013). Quantitative and Multiplexed MicroRNA Sensing in Living Cells Based on Peptide Nucleic Acid and Nano Graphene Oxide (PANGO). ACS Nano. https://doi.org/10.1021/nn401183s
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