The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
An Exceptionally Simple Strategy for DNA-Functionalized Up-Conversion Nanoparticles as Biocompatible Agents for Nanoassembly, DNA Delivery, and Imaging
Open accessAbstract
Lanthanide-doped up-conversion nanoparticles (UCNPs) have shown promise in biomedical applications. However, as the UCNPs are normally capped with hydrophobic ligands, it remains challenging to prepare biocompatible UCNPs with specific molecular recognition capabilities. We herein report an exceptionally simple strategy to prepare uniform DNA-modified UCNPs as versatile bioprobes. The approach can directly convert as-prepared hydrophobic UCNPs into water-soluble DNA-UCNPs without any chemical modification of UCNPs or oligonucleotides. Furthermore, DNA molecules on the DNA-UCNPs retain their biorecognition ability, allowing programmable assembly of hybrid nanostructures. More importantly, we show that these DNA-UCNPs are capable of crossing cell membranes without the need of transfection agents, and their use as agents for bioimaging and DNA delivery are also demonstrated. Finally, DNA aptamer-conjugated UCNPs can be readily used for targeted imaging of cancer cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A DNA-based method for rationally assembling nanoparticles into macroscopic materials
Mirkin, C. A., Letsinger, R. L., Mucic, R. C., & Storhoff, J. J. (1996) · Nature · doi:10.1038/382607a0 · Cited by 6,683
Upconversion and Anti-Stokes Processes with f and d Ions in Solids
Auzel, F. (2004) · Chemical Reviews · doi:10.1021/cr020357g · Cited by 5,098
Simultaneous phase and size control of upconversion nanocrystals through lanthanide doping
Wang, F., Han, Y., Lim, C. S., Lu, Y., Wang, J., Xu, J., Chen, H., Zhang, C., Hong, M., & Liu, X. (2010) · Nature · doi:10.1038/nature08777 · Cited by 3,151
Self-citationRecent advances in the chemistry of lanthanide-doped upconversion nanocrystals
Wang, F., & Liu, X. (2009) · Chemical Society Reviews · doi:10.1039/b809132n · Cited by 3,004
Organization of 'nanocrystal molecules' using DNA
Alivisatos, A. P., Johnsson, K. P., Peng, X., Wilson, T. E., Loweth, C. J., Bruchez, M. P., & Schultz, P. G. (1996) · Nature · doi:10.1038/382609a0 · Cited by 2,962
Seeman, N. C. (2003) · Nature · doi:10.1038/nature01406 · Cited by 2,782
Haase, M., & Schäfer, H. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201005159 · Cited by 2,503
Functional Nucleic Acid Sensors
Liu, J., Cao, Z., & Lu, Y. (2009) · Chemical Reviews · doi:10.1021/cr030183i · Cited by 2,187
Self-citationOligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation
Rosi, N. L., Giljohann, D. A., Thaxton, C. S., Lytton-Jean, A. K. R., Han, M. S., & Mirkin, C. A. (2006) · Science · doi:10.1126/science.1125559 · Cited by 1,988
Upconversion nanophosphors for small-animal imaging
Zhou, J., Liu, Z., & Li, F. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15187h · Cited by 1,581
DNA-guided crystallization of colloidal nanoparticles
Nykypanchuk, D., Maye, M. M., van der Lelie, D., & Gang, O. (2008) · Nature · doi:10.1038/nature06560 · Cited by 1,530
DNA-programmable nanoparticle crystallization
Park, S. Y., Lytton-Jean, A. K. R., Lee, B., Weigand, S., Schatz, G. C., & Mirkin, C. A. (2008) · Nature · doi:10.1038/nature06508 · Cited by 1,515
High-Quality Sodium Rare-Earth Fluoride Nanocrystals: Controlled Synthesis and Optical Properties
Mai, H.-X., Zhang, Y.-W., Si, R., Yan, Z.-G., Sun, L.-D., You, L.-P., & Yan, C.-H. (2006) · Journal of the American Chemical Society · doi:10.1021/ja060212h · Cited by 1,491
Challenges and opportunities for structural DNA nanotechnology
Pinheiro, A. V., Han, D., Shih, W. M., & Yan, H. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.187 · Cited by 1,292
DNA-Programmable Nanoparticle Crystallization*
Park, S. Y., Lytton-Jean, A. K. R., Lee, B., Weigand, S., Schatz, G. C., & Mirkin, C. A. (2020) · Spherical Nucleic Acids · doi:10.1201/9781003056690-3 · Cited by 1,179
Intracellular Glutathione Detection Using MnO2-Nanosheet-Modified Upconversion Nanoparticles
Deng, R., Xie, X., Vendrell, M., Chang, Y.-T., & Liu, X. (2011) · Journal of the American Chemical Society · doi:10.1021/ja2100774 · Cited by 936
Multicolor Core/Shell‐Structured Upconversion Fluorescent Nanoparticles
Li, Z., Zhang, Y., & Jiang, S. (2008) · Advanced Materials · doi:10.1002/adma.200801056 · Cited by 906
Nyk, M., Kumar, R., Ohulchanskyy, T. Y., Bergey, E. J., & Prasad, P. N. (2008) · Nano Letters · doi:10.1021/nl802223f · Cited by 905
Fluorescence Resonant Energy Transfer Biosensor Based on Upconversion‐Luminescent Nanoparticles
Wang, L., Yan, R., Huo, Z., Wang, L., Zeng, J., Bao, J., Wang, X., Peng, Q., & Li, Y. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200501907 · Cited by 901
Bogdan, N., Vetrone, F., Ozin, G. A., & Capobianco, J. A. (2011) · Nano Letters · doi:10.1021/nl1041929 · Cited by 806
Target-Responsive Structural Switching for Nucleic Acid-Based Sensors
Li, D., Song, S., & Fan, C. (2010) · Accounts of Chemical Research · doi:10.1021/ar900245u · Cited by 737
Non-blinking and photostable upconverted luminescence from single lanthanide-doped nanocrystals
Wu, S., Han, G., Milliron, D. J., Aloni, S., Altoe, V., Talapin, D. V., Cohen, B. E., & Schuck, P. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904792106 · Cited by 710
Cheng, L., Yang, K., Li, Y., Chen, J., Wang, C., Shao, M., Lee, S., & Liu, Z. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201101447 · Cited by 650
The Nucleolin Targeting Aptamer AS1411 Destabilizes Bcl-2 Messenger RNA in Human Breast Cancer Cells
Soundararajan, S., Chen, W., Spicer, E. K., Courtenay-Luck, N., & Fernandes, D. J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5723 · Cited by 512
Dhar, S., Daniel, W. L., Giljohann, D. A., Mirkin, C. A., & Lippard, S. J. (2009) · Journal of the American Chemical Society · doi:10.1021/ja9071282 · Cited by 510
Zhang, F., Braun, G. B., Shi, Y., Zhang, Y., Sun, X., Reich, N. O., Zhao, D., & Stucky, G. (2010) · Journal of the American Chemical Society · doi:10.1021/ja909108x · Cited by 475
Yang, Y., Shao, Q., Deng, R., Wang, C., Teng, X., Cheng, K., Cheng, Z., Huang, L., Liu, Z., Liu, X., et al. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201107919 · Cited by 467
Ye, X., Collins, J. E., Kang, Y., Chen, J., Chen, D. T. N., Yodh, A. G., & Murray, C. B. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008958107 · Cited by 457
Upconverting luminescent nanoparticles for use in bioconjugation and bioimaging
Mader, H. S., Kele, P., Saleh, S. M., & Wolfbeis, O. S. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2010.08.014 · Cited by 446
Ju, Q., Tu, D., Liu, Y., Li, R., Zhu, H., Chen, J., Chen, Z., Huang, M., & Chen, X. (2012) · Journal of the American Chemical Society · doi:10.1021/ja2102604 · Cited by 383
DNA Aptamer Folding on Gold Nanoparticles: From Colloid Chemistry to Biosensors
Zhao, W., Chiuman, W., Lam, J. C. F., McManus, S. A., Chen, W., Cui, Y., Pelton, R., Brook, M. A., & Li, Y. (2008) · Journal of the American Chemical Society · doi:10.1021/ja710241b · Cited by 376
Reversible Cell‐Specific Drug Delivery with Aptamer‐Functionalized Liposomes
Cao, Z., Tong, R., Mishra, A., Xu, W., Wong, G. C. L., Cheng, J., & Lu, Y. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200901452 · Cited by 372
Self-citationTime‐Resolved FRET Biosensor Based on Amine‐Functionalized Lanthanide‐Doped NaYF4 Nanocrystals
Tu, D., Liu, L., Ju, Q., Liu, Y., Zhu, H., Li, R., & Chen, X. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201100303 · Cited by 330
Nucleic Acid Conjugated Nanomaterials for Enhanced Molecular Recognition
Wang, H., Yang, R., Yang, L., & Tan, W. (2009) · ACS Nano · doi:10.1021/nn9006303 · Cited by 329
Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates
Lee, J. H., Yigit, M. V., Mazumdar, D., & Lu, Y. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.03.003 · Cited by 293
Self-citationLong‐Term Real‐Time Tracking of Lanthanide Ion Doped Upconverting Nanoparticles in Living Cells
Nam, S. H., Bae, Y. M., Park, Y. I., Kim, J. H., Kim, H. M., Choi, J. S., Lee, K. T., Hyeon, T., & Suh, Y. D. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201007979 · Cited by 273
Biomimetic Surface Engineering of Lanthanide‐Doped Upconversion Nanoparticles as Versatile Bioprobes
Li, L., Zhang, R., Yin, L., Zheng, K., Qin, W., Selvin, P. R., & Lu, Y. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201109156 · Cited by 267
Self-citationHard Proof of the NaYF4/NaGdF4 Nanocrystal Core/Shell Structure
Abel, K. A., Boyer, J.-C., & Veggel, F. C. J. M. V. (2009) · Journal of the American Chemical Society · doi:10.1021/ja906971y · Cited by 259
Liu, Y., Zhou, S., Tu, D., Chen, Z., Huang, M., Zhu, H., Ma, E., & Chen, X. (2012) · Journal of the American Chemical Society · doi:10.1021/ja306066a · Cited by 241
DNA Directed Self-Assembly of Anisotropic Plasmonic Nanostructures
Pal, S., Deng, Z., Wang, H., Zou, S., Liu, Y., & Yan, H. (2011) · Journal of the American Chemical Society · doi:10.1021/ja207898r · Cited by 240
One-step DNA-programmed growth of luminescent and biofunctionalized nanocrystals
Ma, N., Sargent, E. H., & Kelley, S. O. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2008.373 · Cited by 207
Feng, W., Sun, L.-D., Zhang, Y.-W., & Yan, C.-H. (2010) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2010.02.007 · Cited by 165
Wu, S., Duan, N., Wang, Z., & Wang, H. (2011) · The Analyst · doi:10.1039/c0an00735h · Cited by 142
Guo, S., & Wang, E. (2011) · Accounts of Chemical Research · doi:10.1021/ar200001m · Cited by 137
Zhao, W., Gao, Y. B., Srinivas, K. A., Brook, M. A., & Li, Y. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200600061 · Cited by 127
Zhao, W., Gao, Y. B., Srinivas, K. A., Brook, M. A., & Li, Y. (2006) · Angewandte Chemie · doi:10.1002/ange.200600061 · Cited by 127
Changes in Hydration of Lanthanide Ions on Binding to DNA in Aqueous Solution
Costa, D. R. B., Burrows, H. D., & Miguel, M. G. (2005) · Langmuir · doi:10.1021/la051493u · Cited by 74
DNA brings quantum dots to order
Liu, Y. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.126 · Cited by 9
Cited by
NIR-II nanoprobes in-vivo assembly to improve image-guided surgery for metastatic ovarian cancer
Wang, P., Fan, Y., Lu, L., Liu, L., Fan, L., Zhao, M., Xie, Y., Xu, C., & Zhang, F. (2018) · Nature Communications · doi:10.1038/s41467-018-05113-8 · Cited by 451
Min, Y., Li, J., Liu, F., Yeow, E. K. L., & Xing, B. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201308834 · Cited by 309
The biosafety of lanthanide upconversion nanomaterials
Sun, Y., Feng, W., Yang, P., Huang, C., & Li, F. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00175c · Cited by 309
Metadata
- Authors
- Li, L.-L., Wu, P., Hwang, K., & Lu, Y.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-02-07
- Volume
- 135
- Issue
- 7
- Pages
- 2411-2414
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2011928788
- Cited by
- 280
- References
- 48
- FWCI
- 16.73
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
