The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Target-Responsive “Sweet” Hydrogel with Glucometer Readout for Portable and Quantitative Detection of Non-Glucose Targets
Abstract
Portable devices with the advantages of rapid, on-site, user-friendly, and cost-effective assessment are widely applied in daily life. However, only a limited number of quantitative portable devices are commercially available, among which the personal glucose meter (PGM) is the most successful example and has been the most widely used. However, PGMs can detect only blood glucose as the unique target. Here we describe a novel design that combines a glucoamylase-trapped aptamer-cross-linked hydrogel with a PGM for portable and quantitative detection of non-glucose targets. Upon target introduction, the hydrogel collapses to release glucoamylase, which catalyzes the hydrolysis of amylose to produce a large amount of glucose for quantitative readout by the PGM. With the advantages of low cost, rapidity, portability, and ease of use, the method reported here has the potential to be used by the public for portable and quantitative detection of a wide range of non-glucose targets.
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Cites
Shen, F., Sun, B., Kreutz, J. E., Davydova, E. K., Du, W., Reddy, P. L., Joseph, L. J., & Ismagilov, R. F. (2011) · Journal of the American Chemical Society · doi:10.1021/ja2060116 · Cited by 231
Cited by
Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy
Meng, H.-M., Liu, H., Kuai, H., Peng, R., Mo, L., & Zhang, X.-B. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00645g · Cited by 608
Paper Electrode-Based Flexible Pressure Sensor for Point-of-Care Immunoassay with Digital Multimeter
Yu, Z., Tang, Y., Cai, G., Ren, R., & Tang, D. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.8b04635 · Cited by 341
Polymeric DNA hydrogel: Design, synthesis and applications
Li, F., Tang, J., Geng, J., Luo, D., & Yang, D. (2019) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2019.101163 · Cited by 308
Metadata
- Authors
- Yan, L., Zhu, Z., Zou, Y., Huang, Y., Liu, D., Jia, S., Xu, D., Wu, M., Zhou, Y., Zhou, S., & Yang, C. J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-01-29
- Volume
- 135
- Issue
- 10
- Pages
- 3748-3751
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2325415030
- Cited by
- 329
- References
- 1
- FWCI
- 13.99
- Type
- journal article
- Language
- en
- Open access
- closed
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