The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Paper Electrode-Based Flexible Pressure Sensor for Point-of-Care Immunoassay with Digital Multimeter
Abstract
High Resolution Image Download MS PowerPoint Slide A novel paper electrode-based flexible pressure sensor modified with multiwalled carbon nanotubes was designed for point-of-care (POC) immunoassay of carcinoembryonic antigen (CEA) with digital multimeter readout. The portable POC testing device consisted of flexible pressure sensor equipped with a paper electrode and connected through syringe tubing to a single-break microplate. The immunoreaction was initially carried out on the microplate with a sandwich-type assay format using platinum nanozyme-labeled secondary antibody for the gas generation. Upon addition of hydrogen peroxide (H 2 O 2 ), platinum nanozyme (catalase-like mimic) reduced it into hydrogen oxide and oxygen (O 2 ). The overflowing oxygen gas increased the pressure of the multiwalled carbon nanotube-functionalized paper electrode in a homemade pressure-tight system, and the increased pressure could be readily monitored using the paper electrode-based flexible pressure-tight sensor with a digital multimeter readout. The detectable signal mainly derived from the resistance change of pressure sensor because of its deformation with the assistance of the as-generated gas, and the shift in the resistance could be allowed to detect the gas pressure even as low as 80 Pa. Under optimum conditions, pressure sensor-based immunoassay exhibited good resistance responses toward target CEA within a linear range of 0.5–60 ng/mL at a detection limit of 167 pg/mL. Moreover, our strategy provided acceptable reproducibility, precision, high specificity, and good accordance with the commercial CEA ELISA kit for detecting human serum specimens.
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Self-citationProgress of flexible strain sensors for physiological signal monitoring
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Metadata
- Authors
- Yu, Z., Tang, Y., Cai, G., Ren, R., & Tang, D.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-12-20
- Volume
- 91
- Issue
- 2
- Pages
- 1222-1226
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2906408314
- Cited by
- 341
- References
- 18
- FWCI
- 16.99
- Type
- journal article
- Language
- en
- Open access
- closed
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