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Cited by 245

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Substrate-Initiated Synthesis of Cell-Penetrating Poly(disulfide)s

Open access
Bang, Eun-Kyoung, Gasparini, Giulio, Molinard, Guillaume, Roux, Aurélien, Sakai, Naomi, Matile, Stefan·2013·Journal of the American Chemical Society

Abstract

Lessons from surface-initiated polymerization are applied to grow cell-penetrating poly(disulfide)s directly on substrates of free choice. Reductive depolymerization after cellular uptake should then release the native substrates and minimize toxicity. In the presence of thiolated substrates, propagators containing a strained disulfide from asparagusic or, preferably, lipoic acid and a guanidinium cation polymerize into poly(disulfide)s in less than 5 min at room temperature at pH 7. Substrate-initiated polymerization of cationic poly(disulfide)s and their depolymerization with dithiothreitol causes the appearance and disappearance of transport activity in fluorogenic vesicles. The same process is further characterized by gel-permeation chromatography and fluorescence resonance energy transfer.

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Crossref · 10.1021/ja311961k

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Metadata

Authors
Bang, E.-K., Gasparini, G., Molinard, G., Roux, A., Sakai, N., & Matile, S.
Venue
Journal of the American Chemical Society
Published
2013-02-04
Volume
135
Issue
6
Pages
2088-2091
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
OpenAlex
W2012596484
Cited by
245
References
1
FWCI
6.18
Type
journal article
Language
en
Open access
green

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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