Phospholipids and the origin of cationic gating charges in voltage sensors

Intermolecular and Surface Forces

(2011) · Elsevier eBooks · doi:10.1016/b978-0-12-391927-4.10024-6 · Cited by 17,234 · see citing works

Intermolecular and Surface Forces

(2011) · Elsevier eBooks · doi:10.1016/c2011-0-05119-0 · Cited by 9,144 · see citing works

Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K + Channel

Long, S. B., Campbell, E. B., & MacKinnon, R. (2005) · Science · doi:10.1126/science.1116269 · Cited by 2,159 · see citing works

X-ray structure of a voltage-dependent K+ channel

Jiang, Y., Lee, A., Chen, J., Ruta, V., Cadène, M., Chait, B. T., & MacKinnon, R. (2003) · Nature · doi:10.1038/nature01580 · Cited by 1,798 · see citing works

Crystal structure and mechanism of a calcium-gated potassium channel

Jiang, Y., Lee, A., Chen, J., Cadène, M., Chait, B. T., & MacKinnon, R. (2002) · Nature · doi:10.1038/417515a · Cited by 1,332 · see citing works

Voltage Sensor of Kv1.2: Structural Basis of Electromechanical Coupling

Long, S. B., Campbell, E. B., & MacKinnon, R. (2005) · Science · doi:10.1126/science.1116270 · Cited by 982 · see citing works

The principle of gating charge movement in a voltage-dependent K+ channel

Jiang, Y., Ruta, V., Chen, J., Lee, A., & MacKinnon, R. (2003) · Nature · doi:10.1038/nature01581 · Cited by 781 · see citing works

Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor

Murata, Y., Iwasaki, H., Sasaki, M., Inaba, K., & Okamura, Y. (2005) · Nature · doi:10.1038/nature03650 · Cited by 673 · see citing works

Ion Channel Reconstitution

Miller, C. (1986) · Springer eBooks · doi:10.1007/978-1-4757-1361-9 · Cited by 605 · see citing works

Voltage gating of ion channels

Sigworth, F. J. (1994) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583500002894 · Cited by 413 · see citing works

Structure of the KvAP voltage-dependent K + channel and its dependence on the lipid membrane

Lee, S., Lee, A., Chen, J., & MacKinnon, R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507651102 · Cited by 304 · see citing works

Single Streptomyces lividans K+ Channels

Heginbotham, L., LeMasurier, M., Kolmakova-Partensky, L., & Miller, C. (1999) · The Journal of General Physiology · doi:10.1085/jgp.114.4.551 · Cited by 293 · see citing works

Interface connections of a transmembrane voltage sensor

Freites, J. A., Tobias, D. J., von HEIJNE, G., & White, S. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507618102 · Cited by 220 · see citing works

Functional analysis of an archaebacterial voltage-dependent K+ channel

Ruta, V., Jiang, Y., Lee, A., Chen, J., & MacKinnon, R. (2003) · Nature · doi:10.1038/nature01473 · Cited by 208 · see citing works

Role of surface electrostatics in the operation of a high-conductance calcium-activated potassium channel

MacKinnon, R., Latorre, R., & Miller, C. (1989) · Biochemistry · doi:10.1021/bi00446a020 · Cited by 149 · see citing works

Enzymatic activation of voltage-gated potassium channels

Ramu, Y., Xu, Y., & Lü, Z. (2006) · Nature · doi:10.1038/nature04880 · Cited by 143 · see citing works

Physical and Biological Properties of Cationic Triesters of Phosphatidylcholine

MacDonald, R. C., Ashley, G. W., Shida, M. M., Rakhmanova, V. A., Tarahovsky, Y. S., Pantazatos, D., Kennedy, M. T., Pozharski, E. V., Baker, K. A., Jones, R. D., et al. (1999) · Biophysical Journal · doi:10.1016/s0006-3495(99)77095-5 · Cited by 135 · see citing works

Phospholipid-cationic lipid interactions: influences on membrane and vesicle properties

Campbell, R. B., Balasubramanian, S. V., & Straubinger, R. M. (2001) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(01)00290-5 · Cited by 127 · see citing works

Electron microscopic analysis of KvAP voltage-dependent K+ channels in an open conformation

Jiang, Q., Wang, D., & MacKinnon, R. (2004) · Nature · doi:10.1038/nature02735 · Cited by 119 · see citing works

High-Level Expression and Functional Reconstitution of Shaker K+ Channels

Sun, T., Naini, A. A., & Miller, C. (1994) · Biochemistry · doi:10.1021/bi00199a024 · Cited by 35 · see citing works

Conotoxins as Sensors of Local pH and Electrostatic Potential in the Outer Vestibule of the Sodium Channel

Hui, K., McIntyre, D. D., & French, R. J. (2003) · The Journal of General Physiology · doi:10.1085/jgp.200308842 · Cited by 18 · see citing works

Transport phenomena in nanofluidics

Schoch, R. B., Han, J., & Renaud, P. (2008) · Reviews of Modern Physics · doi:10.1103/revmodphys.80.839 · Cited by 1,940 · see citing works

Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment

Long, S. B., Tao, X., Campbell, E. B., & MacKinnon, R. (2007) · Nature · doi:10.1038/nature06265 · Cited by 1,411 · see citing works

Mechanism of Voltage Gating in Potassium Channels

Jensen, M. Ø., Jogini, V., Borhani, D. W., Leffler, A. E., Dror, R. O., & Shaw, D. E. (2012) · Science · doi:10.1126/science.1216533 · Cited by 606 · see citing works

Ion Channel Voltage Sensors: Structure, Function, and Pathophysiology

Catterall, W. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.021 · Cited by 570 · see citing works

Structures of Human Host Defense Cathelicidin LL-37 and Its Smallest Antimicrobial Peptide KR-12 in Lipid Micelles

Wang, G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805533200 · Cited by 483 · see citing works

Molecular dynamics simulations suggest a mechanism for translocation of the HIV-1 TAT peptide across lipid membranes

Herce, H. D., & Garcı́a, A. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706574105 · Cited by 469 · see citing works

Membranes: A meeting point for lipids, proteins and therapies

Escribá, P. V., González‐Ros, J. M., Goñi, F. M., Kinnunen, P. K. J., Vigh, L., Sánchez‐Magraner, L., Fernández, A. M., Busquets, X., Horváth, I., & Barceló‐Coblijn, G. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00281.x · Cited by 454 · see citing works

Recent synthetic transport systems

Matile, S., Jentzsch, A. V., Montenegro, J., & Fin, A. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00209g · Cited by 374 · see citing works

Lateral Pressure Profile, Spontaneous Curvature Frustration, and the Incorporation and Conformation of Proteins in Membranes

Marsh, D. (2007) · Biophysical Journal · doi:10.1529/biophysj.107.107938 · Cited by 369 · see citing works

The Different Interactions of Lysine and Arginine Side Chains with Lipid Membranes

Li, L., Vorobyov, I. V., & Allen, T. W. (2013) · The Journal of Physical Chemistry B · doi:10.1021/jp405418y · Cited by 341 · see citing works

Protein modulation of lipids, and vice-versa, in membranes

Marsh, D. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.01.015 · Cited by 320 · see citing works

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist

Ahuja, S., Mukund, S., Deng, L., Khakh, K., Chang, E., Ho, H., Shriver, S., Young, C., Lin, S., Johnson, J. P., et al. (2015) · Science · doi:10.1126/science.aac5464 · Cited by 319 · see citing works

Arginine-Rich Peptides Destabilize the Plasma Membrane, Consistent with a Pore Formation Translocation Mechanism of Cell-Penetrating Peptides

Herce, H. D., Garcı́a, A. E., Litt, J., Kane, R. S., Martín, P., Enrique, N., Rebolledo, A., & Milesi, V. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2009.05.066 · Cited by 305 · see citing works

Molecular mechanisms in signal transduction at the membrane

Groves, J. T., & Kuriyan, J. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1844 · Cited by 301 · see citing works

Feeling the hidden mechanical forces in lipid bilayer is an original sense

Anishkin, A., Loukin, S. H., Teng, J., & Kung, C. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313364111 · Cited by 299 · see citing works

Sensing voltage across lipid membranes

Swartz, K. J. (2008) · Nature · doi:10.1038/nature07620 · Cited by 293 · see citing works

Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance

Enkavi, G., Javanainen, M., Kulig, W., Róg, T., & Vattulainen, I. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00538 · Cited by 285 · see citing works

Cellular Uptake of Substrate-Initiated Cell-Penetrating Poly(disulfide)s

Gasparini, G. M., Bang, E., Molinard, G., Tulumello, D. V., Ward, S. M., Kelley, S. O., Roux, A., Sakai, N., & Matile, S. (2014) · Journal of the American Chemical Society · doi:10.1021/ja501581b · Cited by 283 · see citing works

New tricks for old dogs: improving the accuracy of biomolecular force fields by pair-specific corrections to non-bonded interactions

Yoo, J., & Aksimentiev, A. (2018) · Physical Chemistry Chemical Physics · doi:10.1039/c7cp08185e · Cited by 267 · see citing works

Common Folds and Transport Mechanisms of Secondary Active Transporters

Shi, Y. (2013) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-083012-130429 · Cited by 277 · see citing works

Vascular mechanotransduction

Davis, M. J., Earley, S., Li, Y.-S., & Chien, S. (2023) · Physiological Reviews · doi:10.1152/physrev.00053.2021 · Cited by 273 · see citing works

Ancillary Subunits Associated With Voltage-Dependent K + Channels

Pongs, O., & Schwarz, J. R. (2010) · Physiological Reviews · doi:10.1152/physrev.00020.2009 · Cited by 269 · see citing works

Closing In on the Resting State of the Shaker K+ Channel

Pathak, M. M., Yarov-Yarovoy, V. M., Agarwal, G., Roux, B., Barth, P., Kohout, S. C., Tombola, F., & Isacoff, E. Y. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.023 · Cited by 260 · see citing works

Substrate-Initiated Synthesis of Cell-Penetrating Poly(disulfide)s

Bang, E., Gasparini, G. M., Molinard, G., Roux, A., Sakai, N., & Matile, S. (2013) · Journal of the American Chemical Society · doi:10.1021/ja311961k · Cited by 248 · see citing works

Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory

Cournia, Z., Allen, T. W., Andricioaei, I., Antonny, B., Baum, D., Brannigan, G., Buchete, N.-V., Deckman, J. T., Delemotte, L., del Val, C., et al. (2015) · The Journal of Membrane Biology · doi:10.1007/s00232-015-9802-0 · Cited by 235 · see citing works

Structural Mechanism of Voltage-Dependent Gating in an Isolated Voltage-Sensing Domain

Li, Q., Wanderling, S., Paduch, M., Medovoy, D., Singharoy, A., McGreevy, R., Villalba-Galea, C., Hulse, R., Roux, B., Schulten, K., et al. (2013) · Nature Structural &Molecular Biology · doi:10.1038/nsmb.2768 · Cited by 245 · see citing works

Molecular mechanisms of phagocytic uptake in mammalian cells

Groves, E., Dart, A., Covarelli, V., & Caron, E. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7578-4 · Cited by 224 · see citing works

Toward high-resolution prediction and design of transmembrane helical protein structures

Barth, P., Schonbrun, J., & Baker, D. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702515104 · Cited by 227 · see citing works

K + Channels: Function‐Structural Overview

Gonzalez, C. L., Báez-Nieto, D., Valencia, I., Oyarzún, I., Rojas, P., Naranjo, D., & Latorre, R. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110047 · Cited by 270 · see citing works

What Makes a Natural Clay Antibacterial?

Williams, L. B., Metge, D. W., Eberl, D. D., Harvey, R. W., Turner, A. G., Prapaipong, P., & Poret‐Peterson, A. T. (2011) · Environmental Science & Technology · doi:10.1021/es1040688 · Cited by 213 · see citing works

Asymmetric Droplet Interface Bilayers

Hwang, W. L., Chen, M., Cronin, B., Holden, M. A., & Bayley, H. (2008) · Journal of the American Chemical Society · doi:10.1021/ja802089s · Cited by 206 · see citing works

Role of arginine and lysine in the antimicrobial mechanism of histone‐derived antimicrobial peptides

Cutrona, K. J., Kaufman, B. A., Figueroa, D. M., & Elmore, D. E. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.11.002 · Cited by 205 · see citing works

Portability of paddle motif function and pharmacology in voltage sensors

Alabi, A. A., Bahamonde, M. I., Jung, H. J., Kim, J. I., & Swartz, K. J. (2007) · Nature · doi:10.1038/nature06266 · Cited by 204 · see citing works

Lipids and membrane protein structures

Hunte, C., & Richers, S. (2008) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2008.03.008 · Cited by 196 · see citing works

Nanomechanics of lipid bilayers by force spectroscopy with AFM: A perspective

Garcia-Manyes, S., & Sanz, F. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2009.12.019 · Cited by 195 · see citing works

Structure and hydration of membranes embedded with voltage-sensing domains

Krepkiy, D. V., Mihailescu, M., Freites, J. A., Schow, E. V., Worcester, D. L., Gawrisch, K., Tobias, D. J., White, S. H., & Swartz, K. J. (2009) · Nature · doi:10.1038/nature08542 · Cited by 193 · see citing works

Thiol-Mediated Uptake

Laurent, Q., Martinent, R., Lim, B., Pham, A., Kato, T., López‐Andarias, J., Sakai, N., & Matile, S. (2021) · JACS Au · doi:10.1021/jacsau.1c00128 · Cited by 191 · see citing works

High‐quality 3D structures shine light on antibacterial, anti‐biofilm and antiviral activities of human cathelicidin LL‐37 and its fragments

Wang, G., Mishra, B., Epand, R. F., & Epand, R. M. (2014) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2014.01.016 · Cited by 184 · see citing works

Removal of phospho-head groups of membrane lipids immobilizes voltage sensors of K+ channels

Xu, Y., Ramu, Y., & Lü, Z. (2008) · Nature · doi:10.1038/nature06618 · Cited by 181 · see citing works

Lipid signaling and the modulation of surface charge during phagocytosis

Yeung, T., & Grinstein, S. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00546.x · Cited by 181 · see citing works

Determining membrane protein structures: still a challenge!

Lacapère, J.-J., Pebay‐Peyroula, E., Neumann, J., & Etchebest, C. (2007) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2007.04.001 · Cited by 179 · see citing works

Intermediate states of the Kv1.2 voltage sensor from atomistic molecular dynamics simulations

Delemotte, L., Tarek, M., Klein, M. L., Amaral, C., & Treptow, W. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102724108 · Cited by 176 · see citing works

Nav Channel Mechanosensitivity: Activation and Inactivation Accelerate Reversibly with Stretch

Morris, C. E., & Juranka, P. F. (2007) · Biophysical Journal · doi:10.1529/biophysj.106.101246 · Cited by 166 · see citing works

Actions and Mechanisms of Polyunsaturated Fatty Acids on Voltage-Gated Ion Channels

Elinder, F., & Liin, S. I. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00043 · Cited by 166 · see citing works

Cellular uptake: lessons from supramolecular organic chemistry

Gasparini, G. M., Bang, E., Montenegro, J., & Matile, S. (2015) · Chemical Communications · doi:10.1039/c5cc03472h · Cited by 165 · see citing works

Improved Parameterization of Amine–Carboxylate and Amine–Phosphate Interactions for Molecular Dynamics Simulations Using the CHARMM and AMBER Force Fields

Yoo, J., & Aksimentiev, A. (2015) · Journal of Chemical Theory and Computation · doi:10.1021/acs.jctc.5b00967 · Cited by 165 · see citing works

Biophysics and function of phosphatidic acid: A molecular perspective

Kooijman, E. E., & Burger, K. N. J. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.04.001 · Cited by 164 · see citing works

Transient receptor potential channels meet phosphoinositides

Nilius, B., Owsianik, G., & Voets, T. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.217 · Cited by 159 · see citing works

Lipid-Dependent Regulation of Ion Channels and G Protein–Coupled Receptors: Insights from Structures and Simulations

Duncan, A. L., Song, W., & Sansom, M. S. P. (2020) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010919-023411 · Cited by 158 · see citing works

How Protein Transmembrane Segments Sense the Lipid Environment

Nyholm, T. K. M., Özdirekcan, S., & Killian, J. A. (2007) · Biochemistry · doi:10.1021/bi061941c · Cited by 156 · see citing works

Voltage-dependent K + channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane

Schmidt, D., & MacKinnon, R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810187105 · Cited by 156 · see citing works

Voltage-Gated Potassium Channels: A Structural Examination of Selectivity and GatingPreprint

Kim, D. M., & Nimigean, C. M. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a029231 · Cited by 154 · see citing works

Lipid ion channels

Heimburg, T. (2010) · Biophysical Chemistry · doi:10.1016/j.bpc.2010.02.018 · Cited by 150 · see citing works

Molecular structures of the human Slo1 K+ channel in complex with β4

Tao, X., & MacKinnon, R. (2019) · eLife · doi:10.7554/elife.51409 · Cited by 149 · see citing works

Sodium Channels in Human Pain Disorders: Genetics and Pharmacogenomics

Dib‐Hajj, S. D., & Waxman, S. G. (2019) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070918-050144 · Cited by 144 · see citing works

Screening Blockers Against a Potassium Channel with a Droplet Interface Bilayer Array

Syeda, R., Holden, M. A., Hwang, W. L., & Bayley, H. (2008) · Journal of the American Chemical Society · doi:10.1021/ja804968g · Cited by 142 · see citing works

Structure, Function, and Modification of the Voltage Sensor in Voltage-Gated Ion Channels

Liin, S. I., & Elinder, F. (2008) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-008-9032-5 · Cited by 141 · see citing works

Targeting voltage sensors in sodium channels with spider toxins

Bosmans, F., & Swartz, K. J. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.12.007 · Cited by 141 · see citing works

Kv1.1 Channels Act as Mechanical Brake in the Senses of Touch and Pain

Hao, J., Padilla, F., Dandonneau, M., Lavebratt, C., Lesage, F., Noël, J., & Delmas, P. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.035 · Cited by 141 · see citing works

Sequential formation of ion pairs during activation of a sodium channel voltage sensor

DeCaen, P. G., Yarov-Yarovoy, V. M., Sharp, E. M., Scheuer, T., & Catterall, W. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912307106 · Cited by 140 · see citing works

Interactions between lipids and voltage sensor paddles detected with tarantula toxins

Milescu, M., Bosmans, F., Lee, S., Alabi, A. A., Kim, J. I., & Swartz, K. J. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1679 · Cited by 137 · see citing works

Dynamics of the Kv1.2 Voltage-Gated K+ Channel in a Membrane Environment

Jogini, V., & Roux, B. (2007) · Biophysical Journal · doi:10.1529/biophysj.107.112540 · Cited by 132 · see citing works

PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating

Zaydman, M. A., & Cui, J. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00195 · Cited by 130 · see citing works

Regulation of transient receptor potential (TRP) channels by phosphoinositides

Rohács, T., & Nilius, B. (2007) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-007-0275-6 · Cited by 128 · see citing works

Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation

DeCaen, P. G., Yarov-Yarovoy, V. M., Zhao, Y., Scheuer, T., & Catterall, W. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806486105 · Cited by 128 · see citing works

PIP2-Binding Site in Kir Channels: Definition by Multiscale Biomolecular Simulations

Stansfeld, P. J., Hopkinson, R. J., Ashcroft, F. M., & Sansom, M. S. P. (2009) · Biochemistry · doi:10.1021/bi9013193 · Cited by 127 · see citing works

Cryo-electron microscopy structure of the Slo2.2 Na+-activated K+ channel

Hite, R. K., Yuan, P., Li, Z., Hsuing, Y., Walz, T., & MacKinnon, R. (2015) · Nature · doi:10.1038/nature14958 · Cited by 125 · see citing works

Stimuli-Responsive Polyguanidino-Oxanorbornene Membrane Transporters as Multicomponent Sensors in Complex Matrices

Hennig, A., Gabriel, G. J., Tew, G. N., & Matile, S. (2008) · Journal of the American Chemical Society · doi:10.1021/ja802587j · Cited by 123 · see citing works

Coarse-grained simulation: a high-throughput computational approach to membrane proteins

Sansom, M. S. P., Scott, K. A., & Bond, P. J. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360027 · Cited by 123 · see citing works

Enzyme Domain Affects the Movement of the Voltage Sensor in Ascidian and Zebrafish Voltage-sensing Phosphatases

Hossain, M. I., Iwasaki, H., Okochi, Y., Chahine, M., Higashijima, S., Nagayama, K., & Okamura, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706184200 · Cited by 118 · see citing works

Polyunsaturated Fatty Acid Modulation of Voltage-Gated Ion Channels

Boland, L. M., & Drzewiecki, M. M. (2008) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-008-9027-2 · Cited by 117 · see citing works

Arginine in Membranes: The Connection Between Molecular Dynamics Simulations and Translocon-Mediated Insertion Experiments

Schow, E. V., Freites, J. A., Myint, P. C., Bernsel, A., von HEIJNE, G., White, S. H., & Tobias, D. J. (2010) · The Journal of Membrane Biology · doi:10.1007/s00232-010-9330-x · Cited by 114 · see citing works

Conformational Changes and Slow Dynamics through Microsecond Polarized Atomistic Molecular Simulation of an Integral Kv1.2 Ion Channel

Bjelkmar, P., Niemelä, P. S., Vattulainen, I., & Lindahl, E. R. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000289 · Cited by 113 · see citing works

Tarantula Toxins Interact with Voltage Sensors within Lipid Membranes

Milescu, M., Vobecky, J., Roh, S., Kim, S. H., Jung, H. J., Kim, J. I., & Swartz, K. J. (2007) · The Journal of General Physiology · doi:10.1085/jgp.200709869 · Cited by 110 · see citing works

Suicide candidate genes associated with bipolar disorder and schizophrenia: An exploratory gene expression profiling analysis of post-mortem prefrontal cortex

Kim, S., Choi, K. H., Baykız, A. F., & Gershenfeld, H. K. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-413 · Cited by 109 · see citing works

Ion-Induced Defect Permeation of Lipid Membranes

Vorobyov, I. V., Olson, T. E., Kim, J. H., Koeppe, R. E., Andersen, O. S., & Allen, T. W. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2013.12.027 · Cited by 108 · see citing works

Lipid-dependent gating of a voltage-gated potassium channel

Zheng, H., Liu, W., Anderson, L. Y., & Jiang, Q.-X. (2011) · Nature Communications · doi:10.1038/ncomms1254 · Cited by 106 · see citing works

The minor binding pocket: a major player in 7TM receptor activation

ROSENKILDE, M. M., Benned‐Jensen, T., Frimurer, T. M., & Schwartz, T. W. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.08.006 · Cited by 105 · see citing works

Single-particle cryo-EM structure of a voltage-activated potassium channel in lipid nanodiscs

Matthies, D., Bae, C., Toombes, G. E. S., Fox, T. L., Bartesaghi, A., Subramaniam, S., & Swartz, K. J. (2018) · eLife · doi:10.7554/elife.37558 · Cited by 106 · see citing works

Transfer of Arginine into Lipid Bilayers Is Nonadditive

MacCallum, J. L., Bennett, W. F. D., & Tieleman, D. P. (2011) · Biophysical Journal · doi:10.1016/j.bpj.2011.05.038 · Cited by 101 · see citing works

Contributions of counter-charge in a potassium channel voltage-sensor domain

Pless, S. A., Galpin, J. D., Niciforovic, A. P., & Ahern, C. A. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.622 · Cited by 99 · see citing works

Solution Structure and Phospholipid Interactions of the Isolated Voltage-Sensor Domain from KvAP

Butterwick, J. A., & MacKinnon, R. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.09.012 · Cited by 96 · see citing works

Mechanism of Electromechanical Coupling in Voltage-Gated Potassium Channels

Blunck, R., & Batulan, Z. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00166 · Cited by 95 · see citing works

How Does a Voltage Sensor Interact with a Lipid Bilayer? Simulations of a Potassium Channel Domain

Sands, Z. A., & Sansom, M. S. P. (2007) · Structure · doi:10.1016/j.str.2007.01.004 · Cited by 93 · see citing works

Coupling of mechanical deformation and electromagnetic fields in biological cells

Torbati, M., Mozaffari, K., Liu, L., & Sharma, P. (2022) · Reviews of Modern Physics · doi:10.1103/revmodphys.94.025003 · Cited by 90 · see citing works

Ionic mechanisms in pancreatic β cell signaling

Yang, S. N., Shi, Y., Yang, G., Li, Y., Yu, J. H., & Berggren, P. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1680-6 · Cited by 91 · see citing works

Structural Dynamics of an Isolated Voltage-Sensor Domain in a Lipid Bilayer

Chakrapani, S., Cuello, L. G., Cortés, D. M., & Perozo, E. (2008) · Structure · doi:10.1016/j.str.2007.12.015 · Cited by 89 · see citing works

State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation

Wu, D., Delaloye, K., Zaydman, M. A., Nekouzadeh, A., Rudy, Y., & Cui, J. (2010) · The Journal of General Physiology · doi:10.1085/jgp.201010408 · Cited by 90 · see citing works

Folding scene investigation: membrane proteins

Booth, P. J., & Curnow, P. (2009) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2008.12.005 · Cited by 89 · see citing works

Voltage-sensor movements in the Eag Kv channel under an applied electric field

Mandala, V. S., & MacKinnon, R. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2214151119 · Cited by 87 · see citing works

Lipid–protein interactions in biological membranes: A dynamic perspective

Smith, A. W. (2011) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2011.06.015 · Cited by 87 · see citing works

Activation of Cell-Penetrating Peptides with Ionpair−π Interactions and Fluorophiles

Chuard, N., Fujisawa, K., Morelli, P., Saarbach, J., Winssinger, N., Metrangolo, P., Resnati, G., Sakai, N., & Matile, S. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b06253 · Cited by 86 · see citing works

Protein folding in membranes

Fiedler, S., Broecker, J., & Keller, S. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0259-0 · Cited by 87 · see citing works

Structural Inhomogeneity of Interfacial Water at Lipid Monolayers Revealed by Surface-Specific Vibrational Pump−Probe Spectroscopy

Bonn, M., Bakker, H. J., Ghosh, A., Yamamoto, S., Sovago, M., & Campen, R. K. (2010) · Journal of the American Chemical Society · doi:10.1021/ja106194u · Cited by 86 · see citing works

Lipid modulation of ion channels through specific binding sites

Poveda, J. A., Giudici, A. M., Renart, M. L., Molina, M. L., Montoya, E., Fernández-Carvajal, A. M., Fernandez-Ballester, G. J., Encinar, J. A., & González-Ros, J. M. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.10.023 · Cited by 85 · see citing works

TRP channels interaction with lipids and its implications in disease

Taberner, F. J., Fernandez-Ballester, G. J., Fernández-Carvajal, A. M., & Ferrer-Montiel, A. V. (2015) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2015.03.022 · Cited by 82 · see citing works

Structural basis of nucleotide sugar transport across the Golgi membrane

Parker, J. L., & Newstead, S. L. (2017) · Nature · doi:10.1038/nature24464 · Cited by 82 · see citing works

Direct and Specific Activation of Human Inward Rectifier K+ Channels by Membrane Phosphatidylinositol 4,5-Bisphosphate

D’Avanzo, N., Cheng, W. W. L., Doyle, D., & Nichols, C. G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.c110.186692 · Cited by 82 · see citing works

Phosphoinositide regulation of TRPV1 revisited

Rohács, T. (2015) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-015-1695-3 · Cited by 82 · see citing works

An electrostatic potassium channel opener targeting the final voltage sensor transition

Liin, S. I., & Elinder, F. (2011) · The Journal of General Physiology · doi:10.1085/jgp.201110599 · Cited by 82 · see citing works

Lipid Chemistry and Mechanical State of the Membrane Modulate Ion Channel Function

Schmidt, D. (2025) · Digital Commons - RU (Rockefeller University) · doi:10.48496/wt1f-z169

Removal of phospho-head groups of membrane lipids immobilizes voltage sensors of K+ channels

Xu, Y., Ramu, Y., & Lü, Z. (2008) · Nature · doi:10.1038/nature06618 · Cited by 181 · see citing works

ARTICLE

Zheng, H., Liu, W., Anderson, L. Y., & Jiang, Q.-X. (2016)

Probing Voltage Sensors In Nonphospholipid Bilayers

Zheng, H., Liu, W., & Jiang, Q. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2008.12.2492

Phosphatidic acid modulation of Kv channel voltage sensor function

Hite, R. K., Butterwick, J. A., & MacKinnon, R. (2014) · eLife · doi:10.7554/elife.04366 · Cited by 62 · see citing works