The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Improving cellular uptake of therapeutic entities through interaction with components of cell membrane
Open accessAbstract
Efficient cellular delivery of biologically active molecules is one of the key factors that affect the discovery and development of novel drugs. The plasma membrane is the first barrier that prevents direct translocation of chemic entities, and thus obstructs their efficient intracellular delivery. Generally, hydrophilic small molecule drugs are poor permeability that reduce bioavailability and thus limit the clinic application. The cellular uptake of macromolecules and drug carriers is very inefficient without external assistance. Therefore, it is desirable to develop potent delivery systems for achieving effective intracellular delivery of chemic entities. Apart from of the types of delivery strategies, the composition of the cell membrane is critical for delivery efficiency due to the fact that cellular uptake is affected by the interaction between the chemical entity and the plasma membrane. In this review, we aimed to develop a profound understanding of the interactions between delivery systems and components of the plasma membrane. For the purpose, we attempt to present a broad overview of what delivery systems can be used to enhance the intracellular delivery of poorly permeable chemic entities, and how various delivery strategies are applied according to the components of plasma membrane.
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Fentahun Darge, H., Yibru Hanurry, E., Simegniew Birhan, Y., Worku Mekonnen, T., Tizazu Andrgie, A., Chou, H.-Y., Lai, J.-Y., & Tsai, H.-C. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.126879 · Cited by 81
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Vidana Gamage, H. E., Albright, S. T., Smith, A. J., Farmer, R., Shahoei, S. H., Wang, Y., Fink, E. C., Jacquin, E., Weisser, E., Bautista, R. O., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217086 · Cited by 13
Metadata
- Authors
- Zhang, R., Qin, X., Kong, F., Chen, P., & Pan, G.
- Venue
- Drug Delivery
- Publisher
- Informa UK Limited
- Published
- 2019-01-01
- Volume
- 26
- Issue
- 1
- Pages
- 328-342
- ISSN
- 1071-7544 (ISSN-L)
- 1521-0464
- OpenAlex
- W2924967653
- Cited by
- 363
- References
- 122
- FWCI
- 9.23
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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