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Rattle-Structured Multifunctional Nanotheranostics for Synergetic Chemo-/Radiotherapy and Simultaneous Magnetic/Luminescent Dual-Mode Imaging
Abstract
Most hypoxic tumors are insensitive to radiation, which is a major obstacle in the development of conventional radiotherapy for tumor treatment. Some drugs, such as cisplatin (CDDP), have been extensively used both as an anticancer drug and clinically as a radiosensitizer to enhance radiotherapy. Herein, we develop rattle-structured multifunctional up-conversion core/porous silica shell nanotheranostics (UCSNs) for delivering CDDP to tumors for synergetic chemo-/radiotherapy by CDDP radiosensitization and magnetic/luminescent dual-mode imaging. UCSNs had a dynamic light scattering diameter of 79.1 nm and excellent water dispersity and stability. In vitro studies showed that CDDP loaded in UCSNs (UCSNs-CDDP) was more effective than free CDDP as a radiosensitizer. After injection, UCSNs-CDDP also demonstrated unambiguously enhanced radiotherapy efficacy in vivo. Our report aims at presenting a novel strategy in biomedical nanotechnology that allows simultaneous dual-mode imaging and localized therapy via synergetic chemo-/radiotherapy, which may achieve optimized therapeutic efficacy in cancer treatment.
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Citations
Cited by
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Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
An overview of nanoparticles commonly used in fluorescent bioimaging
Wolfbeis, O. S. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00392f · Cited by 1,631
Zheng, W., Huang, P., Tu, D., Ma, E., Zhu, H., & Chen, X. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00178h · Cited by 894
Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy
Song, G., Cheng, L., Chao, Y., Yang, K., & Liu, Z. (2017) · Advanced Materials · doi:10.1002/adma.201700996 · Cited by 771
Metadata
- Authors
- Fan, W., Shen, B., Bu, W., Chen, F., Zhao, K., Zhang, S., Zhou, L., Peng, W., Xiao, Q., Xing, H., Liu, J., Ni, D., He, Q., & Shi, J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-04-19
- Volume
- 135
- Issue
- 17
- Pages
- 6494-6503
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1963901824
- Cited by
- 328
- References
- 0
- FWCI
- 26.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fan, W., Shen, B., Bu, W., Chen, F., Zhao, K., Zhang, S., Zhou, L., Peng, W., Xiao, Q., Xing, H., Liu, J., Ni, D., He, Q., & Shi, J. (2013). Rattle-Structured Multifunctional Nanotheranostics for Synergetic Chemo-/Radiotherapy and Simultaneous Magnetic/Luminescent Dual-Mode Imaging. Journal of the American Chemical Society. https://doi.org/10.1021/ja312225b
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