The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Glutathione-Triggered “Off–On” Release of Anticancer Drugs from Dendrimer-Encapsulated Gold Nanoparticles
Abstract
Polymeric nanoparticles that can stably load anticancer drugs and release them in response to a specific trigger such as glutathione are of great interest in cancer therapy. In the present study, dendrimer-encapsulated gold nanoparticles (DEGNPs) were synthesized and used as carriers of thiolated anticancer drugs. Thiol-containing drugs such as captopril and 6-mercaptopurine loaded within DEGNPs showed an "Off-On" release behavior in the presence of thiol-reducing agents such as glutathione and dithiothreitol. Thiolated doxorubicin and cisplatin, loaded within the nanoparticle, showed much reduced cytotoxicity as compared to the free anticancer compounds. The toxicity of drug-loaded DEGNPs can be enhanced by improving the intracellular glutathione. Glutathione-triggered release of thiolated doxorubicin within cancer cells is further confirmed by flow cytometry and confocal laser scan microscopy studies. In addition, DEGNPs showed excellent biocompatibility on several cell lines. This study provides a new insight into biomedical applications of dendrimers and dendrimer-encapsulated nanoparticles.
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Biodegradable dendritic positron-emitting nanoprobes for the noninvasive imaging of angiogenesis
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Cited by
Yusuf, A., Almotairy, A. R. Z., Henidi, H., Alshehri, O. Y., & Aldughaim, M. S. (2023) · Polymers · doi:10.3390/polym15071596 · Cited by 914
Gong, N., Ma, X., Ye, X., Zhou, Q., Chen, X., Tan, X., Yao, S., Huo, S., Zhang, T., Chen, S., et al. (2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0373-6 · Cited by 601
Mechanisms of drug release in nanotherapeutic delivery systems
Wong, P. T., & Choi, S. K. (2015) · Chemical Reviews · doi:10.1021/cr5004634 · Cited by 507
Active targeting of gold nanoparticles as cancer therapeutics
Goddard, Z. R., Marín, M. J., Russell, D. A., & Searcey, M. (2020) · Chemical Society Reviews · doi:10.1039/d0cs01121e · Cited by 282
Activated microglia targeting dendrimer–minocycline conjugate as therapeutics for neuroinflammation.
Sharma, R., Kim, S.-Y., Sharma, A., Zhang, Z., Kambhampati, S. P., Kannan, S., & Kannan, R. M. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00569 · Cited by 100
Metadata
- Authors
- Wang, X., Cai, X., Hu, J., Shao, N., Wang, F., Zhang, Q., Xiao, J., & Cheng, Y.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-06-21
- Volume
- 135
- Issue
- 26
- Pages
- 9805-9810
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2334713953
- Cited by
- 213
- References
- 3
- FWCI
- 15.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, X., Cai, X., Hu, J., Shao, N., Wang, F., Zhang, Q., Xiao, J., & Cheng, Y. (2013). Glutathione-Triggered “Off–On” Release of Anticancer Drugs from Dendrimer-Encapsulated Gold Nanoparticles. Journal of the American Chemical Society. https://doi.org/10.1021/ja402903h
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