Modulating Pharmacokinetics, Tumor Uptake and Biodistribution by Engineered Nanoparticles
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BACKGROUND: Inorganic nanoparticles provide promising tools for biomedical applications including detection, diagnosis and therapy. While surface properties such as charge are expected to play an important role in their in vivo behavior, very little is known how the surface chemistry of nanoparticles influences their pharmacokinetics, tumor uptake, and biodistribution. METHOD/PRINCIPAL FINDINGS: Using a family of structurally homologous nanoparticles we have investigated how pharmacological properties including tumor uptake and biodistribution are influenced by surface charge using neutral (TEGOH), zwitterionic (Tzwit), negative (TCOOH) and positive (TTMA) nanoparticles. Nanoparticles were injected into mice (normal and athymic) either in the tail vein or into the peritoneum. CONCLUSION: Neutral and zwitterionic nanoparticles demonstrated longer circulation time via both i.p. and i.v. administration, whereas negatively and positively charged nanoparticles possessed relatively short half-lives. These pharmacological characteristics were reflected on the tumor uptake and biodistribution of the respective nanoparticles, with enhanced tumor uptake by neutral and zwitterionic nanoparticles via passive targeting.
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The bio-distribution of intraperitoneally and intravenously administrated nanoparticles is similar.
“The bio-distribution of intraperitoneally and intravenously administrated nanoparticles is similar (48).”
From Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps (2016) · cites this paper as [48]
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- Authors
- Arvizo, R. R., Miranda, O. R., Moyano, D. F., Walden, C. A., Giri, K., Bhattacharya, R., Robertson, J. D., Rotello, V. M., Reid, J. M., & Mukherjee, P.
- Affiliations
- Mayo Clinic (US)
- University of Massachusetts Amherst (US)
- University of Missouri (US)
- Corresponding author
- Mukherjee, Priyabrata
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-09-13
- Volume
- 6
- Issue
- 9
- Pages
- e24374
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3172229
- OpenAlex
- W2053311966
- Cited by
- 403
- References
- 43
- Citations by year
- 2026: 11 · 2025: 25 · 2024: 25 · 2023: 27 · 2022: 27 · 2021: 36 · 2020: 37 · 2019: 41 · 2018: 23 · 2017: 34 · 2016: 30 · 2015: 24 · 2014: 21 · 2013: 27 · 2012: 11
- FWCI
- 8.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- National Institutes of Health (GM077173)
- National Cancer Institute (R01CA136494, CA135001, CA136494)
- National Institute of General Medical Sciences (GM-077173, R01GM077173)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Keywords
- engineered nanoparticles, surface charge, surface chemistry, pharmacokinetics, tumor uptake, tissue distribution, circulation time, zwitterionic nanoparticles, passive targeting, nanoparticle clearance, nude mice, intraperitoneal injection, intravenous injection
- MeSH terms
- Animals, Gold, Ligands, Male, Neoplasms, Surface Properties, Time Factors, Tissue Distribution, Nanotechnology, Cell Line, Tumor, Mice, Metal Nanoparticles
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